Halo Meets Horn: Influence of Dissonant Information in Impressions

Abstract The halo effect is a cognitive bias in impression formation that happens when people assume that when a person has a positive trait, such as physical attractiveness, the rest of their characteristics are also positive, leading to an overall positive perception of that person (Thorndike, 1920; Radeke & Stahelski, 2020). Conversely, the horns effect links together a negative trait, such as unattractiveness, with other seemingly negative traits (e.g., selfishness), leading to an overall negative perception (Radeke & Stahelski, 2020). However, these impression formation heuristics can lead to inaccurate impressions and poor judgments (Baumeister & Vohs, 2007). The current study examines the application of cognitive dissonance theory when one becomes aware that the formed impression is inaccurate. It was expected that, the individual would become aware of the inconsistency between reality and the impression, feel aversive (i.e., experience dissonance), and would ultimately work to reduce the dissonance through reduction strategies (Aronson, 1969; Elliot & Devine, 1994; Festinger, 1962; Harmon-Jones & Harmon-Jones, 2007; McGrath, 2017). Results indicated that the halo and horn effect were not present and there was not an overall positive or negative perception due to physical attractiveness. However, condition and information influenced impression ratings

Why crime prevention strategies may be effective against both deliberate and impulsive burglars.

Not all those who commit burglary offenses do so for the same reasons – some are deliberate, planning their actions, while others are more impulsive. In new research on patterns of opportunism among burglars, Amber N. Sanders, Joseph B. Kuhns, and Kristie R. Blevins find that deliberate burglars are more motivated by money, while impulsive burglars were motivated by drugs and/or money. They suggest that burglars of both types may be dissuaded by crime prevention measures which might make their actions riskier

Exploring and Understanding Differences Between Deliberate and Impulsive Male and Female Burglars

Relying on rational choice theory, we compare burglars’ varying levels of offense planning to understand differences among types of burglars. Surveys were collected from a sample of incarcerated male and female burglars in three states. Participants answered questions detailing aspects of a burglary including motivations, target selection, deterrents, and techniques. Comparisons were made between 119 deliberate (32%) and 257 impulsive (68%) burglars. Deliberate burglars focused on obtaining cash, whereas impulsive burglars were more motivated by drug habits. Impulsive burglars were more easily dissuaded from a target when multiple obstacles are present. Burglars consider how many obstacles they may have to overcome, providing support for rational choice-based, situational crime prevention efforts. Differences in burglar motivation emerged and are discussed

Urban Blazers: Fostering Children’s Innate Curiosity and Sense of Adventure

https://digitalcommons.pcom.edu/bridging_gaps2016/1007/thumbnail.jp

Bremelanotide for Treatment of Female Hypoactive Sexual Desire

Hypoactive sexual desire disorder (HSDD) is a persistent deficiency or absence of sexual fantasies and desire resulting in significant distress or interpersonal difficulty. Women with this disorder may display a lack of motivation for sexual activity, reduced responsiveness to erotic cues, a loss of interest during sexual activity, and avoidance of situations that could lead to sexual activity. The pathophysiology of HSDD is thought to be centered around inhibitory and excitatory hormones, neurotransmitters, and specific brain anatomy. Due to the multifactorial nature of HSDD, treatment can be complex and must attempt to target the biological and psychosocial aspects of the disorder. Bremelanotide is a melanocortin receptor agonist and has been recently approved by the FDA to treat HSDD. Bremelanotide is administered intranasally or as a subcutaneous injection. The recommended dosage of bremelanotide is 1.75 mg injected subcutaneously in the abdomen or thigh at least 45 min before sexual activity. Studies showed improvements in desire, arousal, and orgasm scores when 1.75 mg of bremelanotide was administered before sexual activity compared to a placebo. Bremelanotide is a promising way to treat HSDD

The Clinical and Theranostic Values of Activated Leukocyte Cell Adhesion Molecule (ALCAM)/CD166 in Human Solid Cancers

Activated leukocyte cell adhesion molecule (ALCAM), also known as CD166, is a cell adhesion protein that is found in multiple cell types. ALCAM has multiple and diverse roles in various physiological and pathological conditions, including inflammation and cancer. There has been compelling evidence of ALCAM’s prognostic value in solid cancers, indicating that it is a potential therapeutic target. The present article overviews the recent findings and progress in ALCAM and its involvement in cancer, with a primary focus on its clinical connections in cancer and therapeutic values

Metabolic biomarkers assessed with PET/CT predict sex-specific longitudinal outcomes in patients with diffuse large B-cell lymphoma

In many cancers, including lymphoma, males have higher incidence and mortality than females. Emerging evidence demonstrates that one mechanism underlying this phenomenon is sex differences in metabolism, both with respect to tumor nutrient consumption and systemic alterations in metabolism, i.e., obesity. We wanted to determine if visceral fat and tumor glucose uptake with fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) could predict sex-dependent outcomes in patients with diffuse large B-cell lymphoma (DLBCL). We conducted a retrospective analysis of 160 patients (84 males; 76 females) with DLBCL who had imaging at initial staging and after completion of therapy. CT-based relative visceral fat area (rVFA), PET-based SUVmax normalized to lean body mass (SULmax), and end-of-treatment FDG-PET 5PS score were calculated. Increased rVFA at initial staging was an independent predictor of poor OS only in females. At the end of therapy, increase in visceral fat was a significant predictor of poor survival only in females. Combining the change in rVFA and 5PS scores identified a subgroup of females with visceral fat gain and high 5PS with exceptionally poor outcomes. These data suggest that visceral fat and tumor FDG uptake can predict outcomes in DLBCL patients in a sex-specific fashion

Striatins and the STRIPAK complex partners in the clinical outcome of patients with breast cancer and responses to drug treatment

Objective: Striatins (STRNs) family, which contains three multi-domain scaffolding proteins, are cornerstones of the striatins interacting phosphatase and kinase (STRIPAK) complex. Although the role of the STRIPAK complex in cancer has become recognized in recent years, its clinical significance in breast cancer has not been fully established. Methods: Using a freshly frozen breast cancer tissue cohort containing both cancerous and adjacent normal mammary tissues, we quantitatively evaluated the transcript-level expression of all members within the STRIPAK complex along with some key interacting and regulatory proteins of STRNs. The expression profile of each molecule and the integrated pattern of the complex members were assessed against the clinical-pathological factors of the patients. The Cancer Genome Atlas (TCGA) dataset was used to evaluate the breast cancer patients' response to chemotherapies. Four human breast cancer cell lines, MDA-MB-231, MDA-MB-361, MCF-7, and SK-BR-3, were subsequently adopted for in vitro work. Results: Here we found that high-level expressions of STRIP2, calmodulin, CCM3, MINK1 and SLMAP were respectively associated with shorter overall survival (OS) of patients. Although the similar pattern observed for STRN3, STRN4 and a contrary pattern observed for PPP2CA, PPP2CB and PPPR1A were not significant, the integrated expression profile of STRNs group and PPP2 group members constitutes a highly significant prognostic indicator for OS [P<0.001, hazard ratio (HR)=2.04, 95% confidence interval (95% CI), 1.36-3.07] and disease-free survival (DFS) (P=0.003, HR=1.40, 95% CI, 1.12-1.75). Reduced expression of STRN3 has an influence on the biological functions including adhesiveness and migration. In line with our clinical findings, the breast cancer cells responded to STRN3 knockdown with changes in their chemo-sensitivity, of which the response is also breast cancer subtype dependent. Conclusions: Our results suggest a possible role of the STRIPAK complex in breast cancer development and prognosis. Among the members, the expression profile of STRN3 presents a valuable factor for assessing patients' responses to drug treatment