Izazivanje želučanih ulceraclja perivagalnom injekcijom tetanus toksina

Gastric erosions have been produced in rabbits by subperitoneal injections of tetanus toxin along the vagus nerves in relation to the oesophagus or anterior wall of the stomach, and into the central end of the cut cervical vagus on one side. Ten rabbits injected in this way with 0.3-1 mg of toxin all showed acute erosions, often haemorrhagic, after periods of 12-146 hr. (a) Four control rabbits treated identically with boiled toxin did not exhibit ulceration. (b) Of 19 normal rabbit stomachs, examined at random, only one had a small erosion. (c) The intravenous injection of toxin was without ulcerative effect. In 9 rabbits the vagi were both cut subdiaphragmatically. Four were killed either 6 or 42 days later, and had no erosion. The other 5 were killed (or died) at comparable times but had been injected in the usual way with toxin 28-48 hr. before death; all showed erosions.Želučani ulkusi bili su izazvani kod kunića subperitonealnim injekcijama tetanus toksina uzduž vagusa na ezofagusu i prednjoj stijenci želuca, i injiciranjem centralnog kraja prerezanog cervikalnog vagusa s jedne strane. 10 kunića bilo je injicirano na taj način dozama od 0,3-1 mg toksina i svi su pokazali akutne erozije, često hemoragične, nakon perioda od 12-146 sati. 4 kontrolna kunića, koji su bili tretirani na isti način kuhanim toksinom, nisu pokazali znakove ulceracija, Izvršeni su pregledi želudaca 19 normalnih kunića, te je samo kod jednoga nađena mala erozija. Intravenozna injekcija toksina nije izazvala ulceracioni efekt. Kod 9 kunića bila su oba vagusa prerezana subdijafragmalno, 4 su bila ubijena nakon 6-42 dana i nisu pokazivali nikakvih erozija. Ostalih 5 je ubijeno (ili je uginulo)) u istim vremenskim razmacima. Njima se na uobičajeni način injicirao toksin 28-48 sati prije smrti, i svi su pokazivali erozije

Inhibition of post-ganglionic motor transmission in vas deferens by indirectily acting sympathomimetic drugs

Usando um campo elétrico estimulador, com séries curtas de pulsos (menor que 10 por série), a transmissão motora pós-ganglionar nos vasos deferentes de mamíferos foi posteriormente analisada do ponto de vista farmacológico