1 research outputs found
Probiotic Strain <i>Bifidobacterium animalis</i> subsp. <i>lactis</i> CECT 8145 Reduces Fat Content and Modulates Lipid Metabolism and Antioxidant Response in <i>Caenorhabditis elegans</i>
Recently,
microbial changes in the human gut have been proposed
as a possible cause of obesity. Therefore, modulation of microbiota
through probiotic supplements is of great interest to support obesity
therapeutics. The present study examines the functional effect and
metabolic targets of a bacterial strain, <i>Bifidobacterium animalis</i> subsp. <i>lactis</i> CECT 8145, selected from a screening
in <i>Caenorhabditis elegans</i>. This strain significantly
reduced total lipids (40.5% ± 2.4) and triglycerides (27.6% ±
0.5), exerting antioxidant effects in the nematode (30% ± 2.8
increase in survival vs control); activities were also preserved in
a final food matrix (milk). Furthermore, transcriptomic and metabolomic
analyses in nematodes fed with strain CECT 8145 revealed modulation
of the energy and lipid metabolism, as well as the tryptophan metabolism
(satiety), as the main metabolic targets of the probiotic. In conclusion,
our study describes for the first time a new <i>B. animalis</i> subsp. <i>lactis</i> strain, CECT 8145, as a promising
probiotic for obesity disorders. Furthermore, the data support future
studies in obesity murine models