Thyroid Dysfunction caused by Tyrosine Kinase Inhibitors in Philadelphia Chromosome Positive Chronic Myeloid Leukemia

BACKGROUND: Thyroid dysfunction is a known adverse effect of tyrosine kinase inhibitors. Imatinib shown to induce overt hypothyroidism in hypothyroid patients. Very few retrospective studies are available for CML patients treated with Imatinib, which have demonstrated conflicting effects on thyroid function. AIMS AND OBJECTIVES: To investigate the effect of tyrosine kinase inhibitors on thyroid function. Study design: We have prospectively studied Thyroid function before the start of Imatinib therapy and during the course of minimum 6 months duration of therapy in 100 Philadelphia chromosome positive CML patients. RESULTS: Out of 100 patients before imatinib therapy, 9% showed subclinical hypothyroidism and 91% showed euthyroid status. After 6 months of treatment, 5% were hypothyroid out of 91% patients and 9% of Patients with subclinical hypothyroidism had worsening of thyroid profile. CONCLUSION: Although the incidence of hypothyroidism in our study population was insignificant the presence of statistically significant TSH increase makes it mandatory to screen thyroid profile in CML patients before the start of tyrosine kinase inhibitors

“The Social Media Blue Bird Creating an Online Sensation”: A Sentimental Analysis with Reference to Coke-studio Hashtags

Coke-Studio, an online platform hosted in YouTube has been successful in both countries and has been discussed on another popular social media platform Twitter. However, studies report that Pakistan Coke-studio fares better in terms of its emotive content than its Indian edition. The paper analyses how the ―Hashtag fever‖ which has created a huge impact on brand image and profitability position of firms all around the world leads to the differential approach. Though a detailed Social Media Analysis (SMA), this paper aims to examine how hashtags work on the Twitter platforms and conclude how social-media often offers a glimpse of subconscious consumer preferences and its implications thereof

Combating attention deficit hyperactivity disorder with natural treatment

542-549Attention deficit hyperactivity disorder (ADHD) is a weakening mental health problem that hampers the child development. Both the hereditary and ecological elements are the primary causes behind the challenge and possibly will be different among persons. The drugs are used for ADHD may be enhancing the health problem. Therefore, huge requirement of ayurvedic based foodstuff is anticipated among the end users that are expected to be healthy as well as afford additional functional benefits. An ayurvedic plant such as brahmi (Bacopamonnieri and Centellaasiatica) is reported to have much useful functional benefits. Brahmi is well-known to harness reminiscence, perception, being sensible and further mental disorderliness. The present review enlightens the functional properties of brahmi for children with ADHD, including intervention programme

Combating attention deficit hyperactivity disorder with natural treatment

Attention deficit hyperactivity disorder (ADHD) is a weakening mental health problem that hampers the child development. Both the hereditary and ecological elements are the primary causes behind the challenge and possibly will be different among persons. The drugs are used for ADHD may be enhancing the health problem. Therefore, huge requirement of ayurvedic based foodstuff is anticipated among the end users that are expected to be healthy as well as afford additional functional benefits. An ayurvedic plant such as brahmi (Bacopamonnieri and Centellaasiatica) is reported to have much useful functional benefits. Brahmi is well-known to harness reminiscence, perception, being sensible and further mental disorderliness. The present review enlightens the functional properties of brahmi for children with ADHD, including intervention programme

DNA fingerprinting of groundnut (Arachis hypogaea L.) varieties of Tirupati using SSR markers

Unambiguous identification of varieties is important for registration and certification of newly released varieties. Molecular markers are powerful tools, which help in differentiating plant varieties at the DNA level and have been widely used for fingerprinting in a number of crop varieties. In the present study, a set of 12 groundnut varieties released from Regional Agricultural Research Station, Tirupati were fingerprinted employing SSR markers. A total of 300 SSR were screened and fifteen potential markers were employed for fingerprinting of groundnut varieties. The SSR markers generated alleles ranging from 2 to 7 with an average of four per locus. The polymorphism information content (PIC) values ranged from 0 to 0.85. The genotypic data from all the loci provided unique SSR allelic fingerprints which helped in varietal identification of groundnut. Core set of highly informative primers viz., PM 377, TC1A02, TC5A06 and GM1489 identified in this study has the potential to identify most of the groundnut varieties. Cluster analysis using SSR marker grouped 12 groundnut varieties into two major clusters. Finger printing of the groundnut genotypes provide information about phylogenetic relationships and assists groundnut breeders in varietal registration and protection of intellectual property rights

Effects of irrigation fluid in shoulder arthroscopy

Background and Aims: Extravasation of irrigation fluid used in shoulder arthroscopy can lead to life-threatening airway and systemic complications. This study was conducted to assess the effect of irrigation fluid absorption on measurable anthropometric parameters and to identify whether these parameters predict airway/respiratory compromise. Methods: Thirty six American Society of Anaesthesiologists physical status one or two patients aged 15–60 years undergoing shoulder arthroscopy under general anaesthesia were recruited. Measured variables preoperatively (baseline) and at the end of surgery were neck, chest, midarm and midthigh circumferences, weight, haemoglobin and serum sodium. Temperature, endotracheal tube cuff pressure, airway pressure, duration of surgery, amount of irrigation fluid and intravenous fluid used were also noted. Measured parameters were correlated with the duration of surgery and the amount of irrigation fluid used. Results: Postoperatively, the changes in variables showed a significant increase in the mean values (cm) for neck, chest, midarm and midthigh circumference (mean ± standard deviation: 2.35 ± 1.9, P < 0.001; 2.9 ± 3.88 cm, P < 0.001; 3.28 ± 2.44, P < 0.001 and 0.39 ± 0.71, P = 0.002, respectively) and weight (kg) (1.17 ± 1.24, P < 0.001). The post-operative haemoglobin (g/dL) levels decreased significantly (0.89 ± 1.23, P < 0.001) as compared to the baseline. No significant change was found in the serum sodium levels (P = 0.92). No patient experienced airway/respiratory compromise. Conclusion: Regional and systemic absorption of irrigation fluid in arthroscopic shoulder surgery is reflected in the degree of change in the measured anthropometric variables. However, this change was not significant enough to cause airway/respiratory compromise