Canonical Transformations in a Higher-Derivative Field Theory

It has been suggested that the chiral symmetry can be implemented only in classical Lagrangians containing higher covariant derivatives of odd order. Contrary to this belief, it is shown that one can construct an exactly soluble two-dimensional higher-derivative fermionic quantum field theory containing only derivatives of even order whose classical Lagrangian exhibits chiral-gauge invariance. The original field solution is expressed in terms of usual Dirac spinors through a canonical transformation, whose generating function allows the determination of the new Hamiltonian. It is emphasized that the original and transformed Hamiltonians are different because the mapping from the old to the new canonical variables depends explicitly on time. The violation of cluster decomposition is discussed and the general Wightman functions satisfying the positive-definiteness condition are obtained.Comment: 12 pages, LaTe

Extended-release niacin increases anti-apolipoprotein A-I antibodies that block the antioxidant effect of high-density lipoprotein-cholesterol: the EXPLORE clinical trial.

Extended-release niacin (ERN) is the most effective agent for increasing high-density lipoprotein-cholesterol (HDL-C). Having previously identified anti-HDL antibodies, we investigated whether ERN affected the antioxidant capacity of HDL and whether ERN was associated with the production of antibodies against HDL (aHDL) and apolipoprotein A-I (aApoA-I). METHODS: Twenty-one patients older than 18 years, with HDL-C ≤40 mg dl-1 (men) or ≤50 mg dl-1 (women) were randomly assigned to receive daily ERN (n = 10) or placebo (n = 11) for two sequential 12-week periods, with 4 weeks of wash-out before cross-over. Primary outcome was change of paraoxonase-1 (PON1) activity and secondary outcomes were changes in aHDL and aApoA-I antibodies. Clinical Trial Unique Identifier: EudraCT 2006-006889-42. RESULTS: The effect of ERN on PON1 activity was nonsignificant (coefficient estimate 20.83 U l-1 , 95% confidence interval [CI] -9.88 to 51.53; P = 0.184). ERN was associated with an increase in HDL-C levels (coefficient estimate 5.21 mg dl-1 , 95% CI 1.16 to 9.25; P = 0.012) and its subclasses HDL2 (coefficient estimate 2.46 mg dl-1 , 95% CI 0.57 to 4.34; P = 0.011) and HDL3 (coefficient estimate 2.73 mg dl-1 , 95% CI 0.47 to 4.98; P = 0.018). ERN was significantly associated with the production of aApoA-I antibodies (coefficient estimate 0.25 μg ml-1 , 95% CI 0.09-0.40; P = 0.001). aApoA-I titres at baseline were correlated with decreased PON activity. CONCLUSIONS: The rise in HDL-C achieved with ERN was not matched by improved antioxidant capacity, eventually hampered by the emergence of aApoA-I antibodies. These results may explain why Niacin and other lipid lowering agents fail to reduce cardiovascular risk.info:eu-repo/semantics/publishedVersio

Six New Galactic Orbits of Globular Clusters in a Milky-Way-Like Galaxy

Absolute proper motions for six new globular clusters have recently been determined. This motivated us to obtain the Galactic orbits of these six clusters both in an axisymmetric Galactic potential and in a barred potential, such as the one of our Galaxy. Orbits are also obtained for a Galactic potential that includes spiral arms. The orbital characteristics are compared and discussed for these three cases. Tidal radii and destruction rates are also computed and discussed.Comment: 29 pages, 11 figures. Accepted for publication in Ap

Simulation and Teaching-Learning in Paediatrics. Essential Topics

Em 2004 começou a funcionar no Hospital de Dona Estefânia um Centro de Simulação de Técnicas em Pediatria ligado à Faculdade de Ciências Médicas da Universidade Nova de Lisboa. A principal inovação relacionou-se com o facto de os estudantes do 5º ano do curso passarem a dispor da oportunidade de treino de procedimentos em modelos (manequins). O objectivo deste estudo foi descrever o funcionamento do referido centro com base nos testemunhos de estudantes e na experiência dos formadores. De acordo com as opiniões expressas, este tipo de treino foi considerado muito relevante para a sua formação. Na generalidade, os estudantes expressaram a necessidade de ampliar a carga horária para esta valência e de maior diversificação de manequins. De acordo com a experiência dos formadores há necessidade de melhorar alguns aspectos relacionados com a logística, e de rendibilizar a utilização do equipamento, abrindo esta área de formação ao ensino pós-graduado nomeadamente ao treino de internos, o que implica um alargamento do protocolo estabelecido entre a Faculdade e o Hospital. Em síntese, reconhecendo embora, as limitações do estudo, os testemunhos de docentes e discentes podem ser considerados como auditoria interna, sugerindo a necessidade de mudanças curriculares e de melhoria de aspectos logísticos essenciais

Percolative phase transition on ferromagnetic insulator manganites: uncorrelated to correlated polaron clusters

In this work, we report an atomic scale study on the ferromagnetic insulator manganite LaMnO$_{3.12}$ using $\gamma-\gamma$ PAC spectroscopy. Data analysis reveals a nanoscopic transition from an undistorted to a Jahn-Teller-distorted local environment upon cooling. The percolation thresholds of the two local environments enclose a macroscopic structural transition (Rhombohedric-Orthorhombic). Two distinct regimes of JT-distortions were found: a high temperature regime where uncorrelated polaron clusters with severe distortions of the Mn$^{3+}$O$_{6}$ octahedra survive up to $T \approx 800 K$ and a low temperature regime where correlated regions have a weaker JT-distorted symmetry.Comment: 4 pages, 4 Figures, submitted to PRL, new version with more data, text reformulate

On fermionic tilde conjugation rules and thermal bosonization. Hot and cold thermofields

A generalization of Ojima tilde conjugation rules is suggested, which reveals the coherent state properties of thermal vacuum state and is useful for the thermofield bosonization. The notion of hot and cold thermofields is introduced to distinguish different thermofield representations giving the correct normal form of thermofield solution for finite temperature Thirring model with correct renormalization and anticommutation properties.Comment: 13 page