Evaluation of some promising indigenous brinjal genotypes under terai region of West Bengal

Present experiment was implemented under the Department of Vegetable and Spice Crops, Uttar Banga Krishi Viswavidyalaya, Coochbehar which situated at terai region of West Bengal during the autumn-winter season of 2019-20 and 2020-21 on 28 highly diversified brinjal genotypes on ten highly important yield and yield attributing traits to assess the extent of involvement of different genetic phenomena in manifestation of important yield related traits and to understand the inter relationship among them to design better selection criteria. Result revealed that there was close proximity in the magnitude among the component of coefficient of variation and these component exhibited high estimates coupled with high heritability for almost all the characters excepting days to first flowers and days to fruit maturity indicated less interference of the environmental factors in the manifestation of these traits. High magnitude of heritability coupled with genetic advance of mean for those character suggested possibility for selecting these characters based on phenotypic performance for further improvement at desired direction. Residual effect from path analysis was 0.1367 at genotypic level which suggested that contribution of the traits under study was approximately 86.5% on yield, argued for appropriate selection of traits for success of present experimental study. From character associationship and path coefficient it was found that expected yield was highly correlated in positive direction with average fruits per plant (0.68 and 0.801), average fruit weight (0.48 and 0.565), numbers of primary branches per plant (0.51 and 0.113); hence, these yield attributing traits were significantly positively related with each other which suggested that simultaneous selective breeding strategy considering these characters for improvement of yield could be rewarding due to  their probable conditioning by additive gene action

Stable Dietary Ora-Curcumin Formulation Protects from Experimental Colitis and Colorectal Cancer

Inflammatory bowel disease (IBD) is a chronic gut disorder that also elevates the risk of colorectal cancer (CRC). The global incidence and severity of IBD are rising, yet existing therapies often lead to severe side effects. Curcumin offers potent anti-inflammatory and chemotherapeutic properties. However, its clinical translation is hindered by rapid metabolism, as well as poor water solubility and stability, which limits its bioavailability. To address these challenges, we developed OC-S, a water-soluble and colon-targeted curcumin formulation that protects against colitis in mice. The current study advances OC-S as a dietary supplement by establishing its stability and compatibility with various commercial dietary products. Further, OC-S exhibited specific binding to inflamed colon tissue, potentially aiding in targeted drug retention at the inflammation site in colitis with diarrhea symptoms. We further investigated its efficacy in vivo and in vitro using a murine model of colitis and tumoroids from APCmin mice. OC-S significantly reduced colitis severity and pro-inflammatory cytokine expression compared with curcumin, even at very low doses (5 mg/kg/day). It also demonstrated higher anti-proliferative activity in CRC cells and colon cancer tumoroids vs. curcumin. Overall, this study demonstrated that OC-S effectively targets and retains water-soluble curcumin at the inflamed colon sites, while showing promise in addressing both colitis and colorectal cancer, which potentially paves the way for OC-S to advance into clinical development as a dietary product for both IBD and CRC

Exploring Microstructural Changes in Structural Analogues of Ibuprofen-Hosted In Situ Gelling System and Its Influence on Pharmaceutical Performance

NoThe present work explores inner structuration of in situ gelling system consisting of glyceryl monooleate (GMO) and oleic acid (OA). The system under study involves investigation of microstructural changes which are believed to govern the pharmaceutical performance of final formulation. The changes which are often termed mesophasic transformation were analysed by small angle X-ray scattering (SAXS), differential scanning calorimetry (DSC), rheology and plane polarised light (PPL) microscopy. The current work revealed transformation of blank system from W/O emulsion to reverse hexagonal structure upon addition of structural analogues of ibuprofen. Such transformations are believed to occur due to increased hydrophobic volume within system as probed by SAXS analysis. The findings of SAXS studies were well supported by DSC, rheology and PPL microscopy. The study established inverse relationship between log P value of structural analogues of ibuprofen and the degree of binding of water molecules to surfactant chains. Such relationship had pronounced effect on sol-gel transformation process. The prepared in situ gelling system showed sustained drug release which followed Higuchi model