3 research outputs found
SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study
- Author
- Aamir Junaid
- Abaalkhail Muath
- Ababneh Adnan
- Ababneh Hazim
- Ababneh Laila
- Ababneh Roba
- Abad-Motos Ane
- Abaker Mussab
- Abary Ryan
- Abass Adam
- Abate Emmanuele
- Abayomi Olukayode
- Abazeed Alaa
- Abbad Bader
- Abbadessa Francesco
- Abbadi Osaid
- Abbakar Malaz
- Abbas Ahmed
- Abbas Alzhraa
- Abbas Asad
- Abbas Aya
- Abbas Jihad
- Abbas Manzar
- Abbas Mohammad
- Abbas Omer
- Abbasov Aykhan
- Abbo Olivier
- Abbott Daniel
- Abbott Tom
- Abboud Omar
- Abd Waleed
- Abd-Elkariem Ahmed
- Abd-Elsalam Sherief
- Abdalah Ahmad
- Abdalhadi Alya
- Abdalla Ahmed
- Abdalla Eman
- Abdalla Samir
- Abdalla Shimaa
- Abdalla Siddig
- Abdallah Emne
- Abdallah Ghaida
- Abdallah Lubna
- Abdallah Munir
- Abdallah Murad Al
- Abdallah Rasha
- Abdalnour Hani
- Abdeen Bashar
- Abdeewi Saedah
- Abdeh Louai
- Abdel-Aleem Mahmoud
- Abdel-Elsalam Wafaa
- Abdel-Fattah Areej
- Abdel-Fattah Nour
- Abdel-Hafez Ibrahim
- Abdelaal Abdelrahman
- Abdelaty Ahmed Adel
- Abdelazeem Khaled
- Abdelaziz Areej
- Abdelaziz Mohammed
- Abdelbagi Mohamad
- Abdelbaset Abouelnour
- Abdeldayem Hesham
- Abdelfattah Mahmoud
- Abdelgadir Alwaleed
- Abdelgalel Khaled
- Abdelghafar Moslem
- Abdelhafez Mohammed
- Abdeljalil Abdelkarim
- Abdelkabir Mohammed
- Abdelkareem Mohamed
- Abdelkarem Mohamed
- Abdelkarim Mostafa
- Abdelkhalek Mohamed
- Abdellah Fatima
- Abdelmajeed Ahmed
- Abdelmalik Abubaker
- Abdelmawla Ahmed
- Abdelrahman Abdelrahman
- Abdelrahman Haneen
- Abdelraouf Ali
- Abdelsamed Ahmed
- Abdelwahab Omar
- Abderrazaq Hafni
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- Abdrabou Ahmed
- Abdualqader Mahmmoud
- Abdul-Jabar Hani
- Abdul-Mumin Alhassan
- Abdulaal Safaa
- Abdulateef Omar
- Abdulfattah Ammar Yasser
- Abdulkareem Amal
- Abdull Mohammed
- Abdullaev Abakar
- Abdullah Abdullah
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- Abdullah Muhammad Tariq
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- Abdullahi Alhassan
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- Abdulmalek Abdulmalek
- Abdulmalik Abdulmuez
- Abdulmohsen Ahmed
- Abdulqawi Nabil
- Abdulrahem Abdullah
- Abdulrahman Mamuda
- Abdulrahman Mohamed
- Abdulrahman Taha
- Abdulsalam Albaraa
- Abdulsalam Fareed
- Abdulsalam Khalifa
- Abdulsalam Moruf
- Abdulwahab Taiceer
- Abdulwahed Eman
- Abdunabi Murad
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- Abe Anthonia
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- Abebrese John Tabiri
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- Almezghwi Heyam
- Almgla Naser
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- Almjersah Abdulrahman
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- Koculen
- KöylĂŒ Zehra Alan
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- Maadany Faraj Al
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- Mahdy Hossam Al
- Makari Reem Al
- Manji Adil Al-Karim
- Maqtari Siham Al
- Mariño Mauricio AgĂŒero
- Martinez Yicel Alvarez
- Maryam A
- Matas Fernando Alcaide
- Mendoza Veronica Alonso
- Mensah Kwasi Agyen
- Mintah Dominic Annor
- Moagal Rehab Al
- Moawad Karim Abdelraouf
- Mohamed Mohamed Ali
- Mohsen Mustafa Abo
- Momani Tareg Al
- Muhfouz Dima Abu
- Muhtadi Fadhl Al
- Mulke Rahaf Al
- Murgueitio Natalia Cortes
- Mutani Mohammed Al
- Nafesa Aminah Al
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- Najjar Majed Al
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- Nassar Saleh Al
- Nepogodiev Dmitri
- Neto Alfeu Accorsi
- Noval Patricia Corriols
- Nwijy Khaled Ai
- Obead Hamza Abu
- Oliver Renato Aguera
- Omair Shehanah Al
- Otaibi Faisal Al
- Picciochi Maria
- Pinto JoĂŁo Almeida
- Polo Miriam Abdulkarim
- Qadhi Hani Al
- Qudhaya Rashed Al
- Qureshi Talha Ahmed
- Rahim Norazila
- Rahman Noorneza Abdul
- Rahman Norhafiza
- Raisi Amani Al
- Rashed Asmaa Al
- Rego Juliana Almeida
- Riaz Shujat Ahmed
- Riobello Eva Andreu
- Riyami Nihal Al
- Riyami Salim Al
- Ros Conrado Andrés
- RosellĂł Irene Vives
- Rubio Eva Corral
- Rueda Ignacio AlcalĂĄ
- Saad Sarah Ahmed
- Sabti Hilal Al
- Saez Iago Alvarez
- Saied Ghiath Al
- Salam Omar Abdul
- Salama Ibrahim Abdelkader
- Sanany Ghadeer Al
- Santos Daniel Costa
- Sayed Mohamed Al
- Sebastian Isabel Alonso
- Shaalah Ahmed Abdullah
- Shaibi Maha Al
- Shaikh Shafqat Ali
- Shanab Ahmed Abo
- Sharie Ahmed Al
- Shukri Asmaa Al
- Simoes Joana
- Smadi Omar Al
- Soares Rui Costa
- Soucheiron Maria Coronas
- Subaie Saud Al
- Suyyagh Kais Al
- Tarieh Ammar Abu
- Torres Eva Alvarez
- Victoria Czarlo Dela
- Villamayor VerĂłnica Alen
- Vinayagam Raman
- Vincenti Cara
- Vincenzi Matteo
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- Virdi Amrita
- Virgilio Edoardo
- Virgincar Ashwini
- Virta Ville P
- Viscido German
- Vishnoi Jeewan Ram
- Vishwakarma Sunil Kumar
- Vishwani Vartika
- Vissapragada Ravi
- Viste Claire
- Viswanath Yks
- Vitowanu Julius
- Viveiros Octavio
- Viveros-Carreño David
- Vives Inmaculada
- Vives-Barquiel Marian
- Vivian-Taylor Josephine
- Vix Michel
- Vlad Ioan Catalin
- Vlad Schitcu
- Vladimir Novgorodskii
- Vleminckx Nils
- Vo Uyen Giao
- Vogel Jon
- Vogel Keianna
- Vogel Rachel
- Vogelsang Holger
- Vogler Thomas
- Vogt Kelly
- Vohra Ravinder
- Vokshi Ismail
- Volkova Olga
- Volpe Gustavo Jardim
- Volpin Enrico
- Volpin Francesco
- von Ehrlich-TreuenstÀtt Viktor H
- von Renesse Janusz
- von Rundstedt Friedrich-Carl
- Voonna Murali Krishna
- Voppuru Saiesh Reddy
- Vora Sameer
- Voros Peter
- Vosoughi Fardis
- Vossler Kristen
- Vounckx Manon
- Vourganti Srinivas
- Vovola Fernanda
- Vozian Marin
- Vrakopoulou Gavriella Zoi
- Vömel Jacob
- Wadei Hajr Al
- Yahya Zakaria Al
- Zahran Mohammed
- Zahrani Attiya Al
- Zahrani Turki Ai
- Zaid Muna
- Zein Zeina Al
- Ălvarez Sofia
- ĂlgĂ„ Andreas
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2021
- Field of study
Background: Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling.
Methods: The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18-49, 50-69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty.
Results: NNVs were more favourable in surgical patients than the general population. The most favourable NNVs were in patients aged 70 years or more needing cancer surgery (351; best case 196, worst case 816) or non-cancer surgery (733; best case 407, worst case 1664). Both exceeded the NNV in the general population (1840; best case 1196, worst case 3066). NNVs for surgical patients remained favourable at a range of SARS-CoV-2 incidence rates in sensitivity analysis modelling. Globally, prioritizing preoperative vaccination of patients needing elective surgery ahead of the general population could prevent an additional 58 687 (best case 115 007, worst case 20 177) COVID-19-related deaths in 1 year.
Conclusion: As global roll out of SARS-CoV-2 vaccination proceeds, patients needing elective surgery should be prioritized ahead of the general population
International Variations in Surgical Morbidity and Mortality Post Gynaecological Oncology Surgery: A Global Gynaecological Oncology Surgical Outcomes Collaborative Led Study (GO SOAR1)
- Author
- Aarti Sharma
- Abdulhadi Othman Alshatshat
- Adefemi Moses Olumodeji
- Ademola Adeyeye
- Agnieszka Rychlik
- Ahmad Al Houri
- Ahmed M Abbas
- Ahmed Nafea
- Alaa Ismail
- Alejandra Martinez
- Alexandra Lawrence
- Alfredo Ercoli
- Alfredo Polo-Velasco
- Ali Al-Isawi
- Ali Elimam
- Alice Zampolini Faustini
- Almu'atasim Khamees
- Alvaro Tejerizo
- Alyaa Raad Bahlol Al-khafaji
- Alyssa Wield
- Amar Al-Jarrah
- Amer Mahmoud Sindiani
- Amr Hamza
- Ana Claudia Frazao Paiva
- Ana Luzarraga Aznar
- Ana Patricia Louise Alvarado
- Andrea Papadia
- Andrej Cokan
- Anik Ghosh
- Anis Feki
- Anisse Tidjane
- Anna Fagotti
- Annapurna Vadaparty
- Antonio Gil-Moreno
- Aqsa Aslam
- Areg Alaverdyan
- Arjun Jeyarajah
- Artem Stepanyan
- Ash Karen
- Aya Zazo
- Ayodeji Kayode Adefemi
- Baraa Hajjaj
- Basel Refky
- Basile Pache
- Bassam Hassan
- Benedetta Guani
- Berta FabregoÌ
- Bizzarri NicoloÌ
- Blanca Gil-IbaÌnÌez
- Blyuss Oleg
- Bruna Tirapelli Gonçalves
- Burak Giray
- Cagatay Taskiran
- Catherine Smith
- Chee Yang Tan
- Chiara Cimmino
- Christine Ang
- Cibula David
- Claudia Bessa Pereira Chaves
- Daniel de Souza Fernandes
- Dario R Roque
- David Atallah
- Davide Arrigo
- Dema Adwan
- Desmond Barton
- Dmitrii Utkin
- Dogan Vatansever
- Domenico Ferraioli
- Edoardo Cola
- Elena Dikareva
- Elena Ulrikh
- Elly Brockbank
- Ester Miralpeix
- Eva TimosÌek
- Fabio Martinelli
- Farah Shahin
- Francesco Raspagliesi
- Gaba Faiza
- Gemma Mancebo
- Giovanni Scambia
- Giulia Ferrante
- Giulia Pellecchia
- Giuseppe Vizzielli
- Glauco Baiocchi
- GO SOAR Collaborators. GO SOAR Collaborators: Mohamedraed Elshami
- Gregorio LoÌpez GonzaÌlez
- Halima A Sh Alhasie
- Hamdi Nawfal
- Hammad Ali Fadlalmola
- Hasan Al Houri
- Hasanthi Assalaarachchi
- Hassan Alsalman
- Hassan Zeinah
- Hazim Ababneh
- Henrik Falconer
- Husameddin Alattar Ashraf
- HuÌseyin Aksoy
- Igor Govorov
- Iman Feghali
- Isabel Janmey
- Jagannath Mishra
- Jallaluddin Akbar
- James Dilley
- Jaydip Bhaumik
- Joao Casanova
- John Butler
- Julia RodriÌguez-SaÌnchez-Reyman
- Kajsa Lidman
- Kamfwa Paul
- Katarzyna Derda
- Kiran Kumar KM
- Lina Karout
- Lorenza Driul
- Lori McPherson
- Lorraine Pearce
- M Vijaykumar
- Maen Alsumadi
- Mahalakshmi Gurumurthy
- Maherah Kamarudin
- Mahmoud Saad
- Manuel Pantoja-Garrido
- Manuela Undurraga
- Marah Al Matar
- Marc Fischer
- Maria Luisa Gasparri
- Mariam Anjum Ifthikar
- Marielle Nobbenhuis
- Martina Aida Angeles
- Martina Arcieri
- Mary Cairns
- Mathilde Del
- Matilde Degano
- Mauro Pelagalli
- Mikhail Novozhilov
- Mohamad Banat
- Mohammad A M Ahmed
- Mohammad Awad
- Mohammed F Ramadan
- Monika Sobocan
- Muhammed Elhadi
- Mukatimui Kalima-Munalula
- Mustafa Ahmad Abu Jayyab
- Mustafa Albokai
- Mustafa M Khodry
- Mustafa Mohamed Ali Hussein
- Mustafa Sabri Massadi
- Nadine El Kassis
- Nana Gomes
- Natalia R Gomez-Hidalgo
- Noor Abualdahab
- Olivia W Foley
- Omar Badaren
- Owen Heath
- Patrice Mathevet
- Pavel Sorokin
- Rafaela Silva De Oliveira
- Ranjit Manchanda
- Rekha Bangalore Bangalore
- Rema Hassan Otman
- Renata PoncovaÌ
- Reyam Abdalla Naana
- Rohan Shetty
- Saiz Allison
- Salah Eddine Oussama Kacimi
- Samer Tarchichi
- Sara Hussein
- Sara Proença
- Saurabh Phadnis
- Seda Şahin Aker
- Shatha Husain
- Shukri Odeh Yousef
- Stefano Restaino
- Svetlana Kulikova
- Swali Fundafunda
- Thomas Ind
- Thumuluru Kavitha Madhuri
- Viktor Ivan Cassar
- ViÌctor Lago
- Wafaâ Alsardieh
- Waleed Elamin
- Wesam Ebrahim Hasan
- Zarema Abduragimova
- Zhirayr Malakyan
- Ziena Obiedat
- Zouhair Amarin
- Zuheir Al-Shehabi
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Simple Summary Little is known about factors contributing to early post-operative morbidity and mortality in low and middle income countries with a paucity of data limiting global efforts to improve gynaecological cancer care. In this multicentre, international prospective cohort study of women undergoing gynaecological oncology surgery, we show that low and middle versus high income countries were associated with similar post-operative major morbidity. Capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention.Abstract Gynaecological malignancies affect women in low and middle income countries (LMICs) at disproportionately higher rates compared with high income countries (HICs) with little known about variations in access, quality, and outcomes in global cancer care. Our study aims to evaluate international variation in post-operative morbidity and mortality following gynaecological oncology surgery between HIC and LMIC settings. Study design consisted of a multicentre, international prospective cohort study of women undergoing surgery for gynaecological malignancies (NCT04579861). Multilevel logistic regression determined relationships within three-level nested-models of patients within hospitals/countries. We enrolled 1820 patients from 73 hospitals in 27 countries. Minor morbidity (Clavien-Dindo I-II) was 26.5% (178/672) and 26.5% (267/1009), whilst major morbidity (Clavien-Dindo III-V) was 8.2% (55/672) and 7% (71/1009) for LMICs/HICs, respectively. Higher minor morbidity was associated with pre-operative mechanical bowel preparation (OR = 1.474, 95%CI = 1.054-2.061, p = 0.023), longer surgeries (OR = 1.253, 95%CI = 1.066-1.472, p = 0.006), greater blood loss (OR = 1.274, 95%CI = 1.081-1.502, p = 0.004). Higher major morbidity was associated with longer surgeries (OR = 1.37, 95%CI = 1.128-1.664, p = 0.002), greater blood loss (OR = 1.398, 95%CI = 1.175-1.664, p <= 0.001), and seniority of lead surgeon, with junior surgeons three times more likely to have a major complication (OR = 2.982, 95%CI = 1.509-5.894, p = 0.002). Of all surgeries, 50% versus 25% were performed by junior surgeons in LMICs/HICs, respectively. We conclude that LMICs and HICs were associated with similar post-operative major morbidity. Capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention
Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries
- Author
- Aarts Frits
- Ababneh Hazim
- Abad-Motos Ane
- Abaidalla Ahmed
- Abbakar Malaz
- Abd El Aal Ahmed
- Abd-Errazik Mohammad Ahmad
- Abdalradiy Abdalrahmman G
- Abdelkhalek Mohamed
- Abdelkhalek Mostafa
- Abdellatif Ahmed
- Abdellatif Mohamed
- Abdelsaid Kirolas
- Abdou Khaled
- Abdulfatah Mustapha
- Abdullah Mohammad Amer
- Abdullahi Mustapha Miko Mohammed
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- Chowdhury Sharfuddin M
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- Christodoulidis Grigorios
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- Danassi Despoina
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- de Andrés-Asenjo Beatriz
- de Deken Julie
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- de La Plaza Llamas Roberto
- de Lacy Antonio Maria
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- de LeĂłn RendĂłn Jorge Luis
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- de Souza Artioli Luana Maria
- de Souza Pires Bruno Lucena
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- EllebĂŠk Mark Bremholm
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- Felix Michael Shalzim
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- Gklavas Antonios
- Glasbey James C
- Golub JĂłzsef
- Gomendio Maria Dolores Picardo
- Gomes Carina
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- Gomez-Rosado Juan-Carlos
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- Gutierrez Victor Manuel Maciel
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- Hallett Abigail
- Halliwell Gail
- Hallworth Stephen
- Hamdan Alaa
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- Hamed Hosam
- Hameed Malika
- Hamid Hytham K S
- Hamilton Vida
- Hammed Amane
- Hamza Amr
- Hanan Bernardo
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- Hansdotter Pernilla
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- Hawkin Paul
- Hayirlioglu Mehmet Bilhan
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- Hererro Juan Antonio Villanueva
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- HernĂĄndez Miguel
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- Hodge Katherine
- Hodzic Samir
- Hoetzel Alexander
- Holzner Philipp
- Hooper Richard
- Hooper Richard L
- Horiguchi Akihiko
- HorvĂĄth Ăva
- Houdin Anabella
- Hoyos-Torres Alejandro
- Hsieh Yi Chien
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- Yılmaz GĂŒlseren
- Yilmazlar Tuncay
- YiÄit Direnç
- Yoldas Tayfun
- Yonekura Hiroshi
- Yorkmui Liu
- Yoshino Kenji
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- Yule Michael
- Yusoff Zakiah Mohd
- Zaari Fatimazahraa
- Zabiyaka Mikhail
- ZadroĆŒna Monika
- Zafar Madiha
- Zagaynov Eugeny
- Zaidi Syed-Nadeem
- Zaimis Tilemachos
- Zain Wan Zainira Wan
- Zainy Rhendra Hardy Mohamad
- Zakaria Andee Dzulkarnaen
- Zakaria Maheen
- Zakaria Zaidi
- Zamudio-Bautista Jorge Luis
- Zanc Loredana
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- Zanus Giacomo
- Zapparoli Alessandro
- Zappone Anna
- Zarzava Eirini
- Zatari Dirar
- Zawadzki Marek
- Zayakov Georgi
- Zaycev Andrey
- Zazo Aya
- Zazo Rama
- Zdravkovic Maja
- Zengin Abdullah KaÄan
- Zeringa Georgia
- Zimmerman David D E
- Zuhdy Mohammad
- Zvirych Vitalii
- Zywicka Ewa
- Ălvarez-Llano Laura
- Ăngelo Miguel Duarte
- ĂSullivan Sara Nuñez
- Ăzçelik Mehmet Faik
- Äoza Ivo
- Ćanlı Ahmet Necati
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background
Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks.
Methods
The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned.
Results
A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31).
Conclusion
Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)