The Association Between Parents History of Type 2 Diabetes with Metabolic Syndrome Component and Insulin Resistance in Non-Diabetic Young Adult Male

Background: the familial nature of type 2 diabetes is manifested by the presence of insulin resistance in non-diabetic first degree relatives. Most of these studies have been performed in middle-aged and there is only few published studies in young age individuals and adolescents. This study aimed to determine the relationship between parents history of type-2 diabetes with metabolic syndrome component and insulin resistance in adolescent non-diabetic subjects. Methods: this was a cross sectional study comparing the metabolic profile, risk of metabolic syndrome and insulin resistance in non-diabetic male adolescents (17-24 years old) whose one or both parents were with type-2 diabetes. We performed anamnesis, physical examination, fasting plasma glucose, lipid profile, fasting insulin level and insulin resistance based on HOMA-IR. Results: metabolic abnormalities were more prevalent in subjects whose parents were with history of type-2 diabetes, especially their waist circumference, fasting plasma glucose, triglyceride, fasting insulin and HOMA-IR (p=0.000). There was increased risk of developing central obesity in adolescents with parental history of 19.3 fold (95%CI 2.46-151.07) and insulin resistance of 10.3 fold (95%CI 3.89-27.23). Parental history of type-2 diabetes together with metabolic syndrome component ie. waist circumference >90 cm and triglyceride ≥150 mg/dl were strong determinat factors for insulin resistance (R2=50.7%). Conclusion: the early multiple metabolic defect can be detected in non-diabetes adolescents with parental history of type-2 diabetes. Cluster of metabolic syndrome component in these subject become  a powerful determinat factor for insulin resistance

Evaluation of Topical Red Dragon Fruit Extract Effect (Hylocereus Polyrhizus) on Tissue Granulation and Epithelialization in Diabetes Mellitus (DM) and Non-DM Wistar Rats: Pre Eliminary Study

The use of natural materials as wound healing is an alternative that is widely used. Red Dragon Fruit Extract (EBNM) has antioxidant and anti-inflammatory content that is needed to accelerate the wound healing, but studies have reported effects on wound healing is still limited. The purpose of this study was to evaluate the effect of topical Red Dragon Fruit Extract on DM wound and Non-DM wound healing in Wistar rats. This research method is an Experimental Study with post-test with control group design. Albino Male Wistar rat (n = 18) with the weight (200-250 grams) were divided into 2 groups (group A (n = 9) Wistar DM + incision divided into 3 groups, each with 3 rats and group B (n = 9) Non-DM Wistar + incision divided into 3 groups of each 3 rats). Furthermore Wistar rat wounded in the back left and right using 8 mm punch biopsy. 7.5% topical Red Dragon Fruit Extract cream was applied to the surface of the wound with the cotton bud. Tissue preparat colored with Hematoxylin and Eosin (HE) then the wound healing parameters were assessed; the thickness of the granulation tissue and epithelialization with histopathology assessment. Data were analyzed using independent T test and paired T test (SPSS 21, Chicago Inc.) Granulation scores tend to be better at a concentration of 7.5% in the topical Red Dragon Fruit Extract than the negative control group for DM (p <0.068) and non-DM (p <0.034). Epithelialization Scores are better at concentrations of 7.5% in Topical Red Dragon Fruit Extract group than the negative control group for DM (p <0.034) and non DM (p <0.034). Topical Red Dragon Fruit Extract 7.5% increase the growth of granulation tissue and epithelialization in wound healing of acute non-DM and DM at Wistar rats

The Association Between Parents History of Type 2 Diabetes with Metabolic Syndrome Component and Insulin Resistance in Non-Diabetic Young Adult Male

Background: the familial nature of type 2 diabetes is manifested by the presence of insulin resistance in non-diabetic first degree relatives. Most of these studies have been performed in middle-aged and there is only few published studies in young age individuals and adolescents. This study aimed to determine the relationship between parents history of type-2 diabetes with metabolic syndrome component and insulin resistance in adolescent non-diabetic subjects. Methods: this was a cross sectional study comparing the metabolic profile, risk of metabolic syndrome and insulin resistance in non-diabetic male adolescents (17-24 years old) whose one or both parents were with type-2 diabetes. We performed anamnesis, physical examination, fasting plasma glucose, lipid profile, fasting insulin level and insulin resistance based on HOMA-IR. Results: metabolic abnormalities were more prevalent in subjects whose parents were with history of type-2 diabetes, especially their waist circumference, fasting plasma glucose, triglyceride, fasting insulin and HOMA-IR (p=0.000). There was increased risk of developing central obesity in adolescents with parental history of 19.3 fold (95%CI 2.46-151.07) and insulin resistance of 10.3 fold (95%CI 3.89-27.23). Parental history of type-2 diabetes together with metabolic syndrome component ie. waist circumference >90 cm and triglyceride ≥150 mg/dl were strong determinat factors for insulin resistance (R2=50.7%). Conclusion: the early multiple metabolic defect can be detected in non-diabetes adolescents with parental history of type-2 diabetes. Cluster of metabolic syndrome component in these subject become  a powerful determinat factor for insulin resistance