The Impact Of Oral Health Education And Preventive Measures On Dental Caries And Periodontal Diseases

Oral problems, including dental caries, periodontal diseases, and tooth loss, are significant global public health concerns. This is due to the fact that inadequate oral health has extensive impacts on general health and quality of life. In improving oral health, especially in developing countries, there are obstacles that need to be addressed. It is crucial to enhance public health programs worldwide by implementing efficient preventative measures against diseases and simultaneously boosting oral health. Frequently, collective actions are employed for the purpose of oral health education. These actions often involve delivering lectures utilizing various materials such as flipcharts, videos, PowerPoint presentations, as well as implementing other activities like supervised teeth brushing and topical fluoride application. This paper aimed to review the impact of oral health education and preventive measures on dental caries and periodontal diseases

Unrevealing the multitargeted potency of 3-1-BCMIYPPA against lung cancer structural maintenance and suppression proteins through pharmacokinetics, QM-DFT, and multiscale MD simulation studies.

Lung cancer, a relentless and challenging disease, demands unwavering attention in drug design research. Single-target drugs have yielded limited success, unable to effectively address this malignancy's profound heterogeneity and often developed resistance. Consequently, the clarion call for lung cancer drug design echoes louder than ever, and multitargeted drug design emerges as an imperative approach in this landscape, which is done by concurrently targeting multiple proteins and pathways and offering a beacon of hope. This study is focused on the multitargeted drug designing approach by identifying drug candidates against human cyclin-dependent kinase-2, SRC-2 domains of C-ABL, epidermal growth factor and receptor extracellular domains, and insulin-like growth factor-1 receptor kinase. We performed the multitargeted molecular docking studies of Drug Bank compounds using HTVS, SP and XP algorithms and poses filter with MM\GBSA against all proteins and identified DB02504, namely [3-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Propyl-]-Phosphonic Acid (3-1-BCMIYPPA) as multitargeted lead with docking and MM\GBSA score range from -8.242 to -6.274 and -28.2 and -44.29 Kcal/mol, respectively. Further, the QikProp-based pharmacokinetic computations and QM-based DFT showed acceptance results against standard values, and interaction fingerprinting reveals that THR, MET, GLY, VAL, LEU, GLU and ASP were among the most interacting residues. The NPT ensemble-based 100ns MD simulation in a neutralised state with an SPC water model has also shown a stable performance and produced deviation and fluctuations <2Å with huge interactions, making it a promising multitargeted drug candidate-however, experimental studies are suggested

CM-CPPA: Chaotic Map-Based Conditional Privacy-Preserving Authentication Scheme in 5G-Enabled Vehicular Networks

The security and privacy concerns in vehicular communication are often faced with schemes depending on either elliptic curve (EC) or bilinear pair (BP) cryptographies. However, the operations used by BP and EC are time-consuming and more complicated. None of the previous studies fittingly tackled the efficient performance of signing messages and verifying signatures. Therefore, a chaotic map-based conditional privacy-preserving authentication (CM-CPPA) scheme is proposed to provide communication security in 5G-enabled vehicular networks in this paper. The proposed CM-CPPA scheme employs a Chebyshev polynomial mapping operation and a hash function based on a chaotic map to sign and verify messages. Furthermore, by using the AVISPA simulator for security analysis, the results of the proposed CM-CPPA scheme are good and safe against general attacks. Since EC and BP operations do not employ the proposed CM-CPPA scheme, their performance evaluation in terms of overhead such as computation and communication outperforms other most recent related schemes. Ultimately, the proposed CM-CPPA scheme decreases the overhead of computation of verifying the signatures and signing the messages by 24.2% and 62.52%, respectively. Whilst, the proposed CM-CPPA scheme decreases the overhead of communication of the format tuple by 57.69%

Provably Secure with Efficient Data Sharing Scheme for Fifth-Generation (5G)-Enabled Vehicular Networks without Road-Side Unit (RSU)

The vehicles in the fifth-generation (5G)-enabled vehicular networks exchange the data about road conditions, since the message transmission rate and the downloading service rate have been considerably brighter. The data shared by vehicles are vulnerable to privacy and security issues. Notably, the existing schemes require expensive components, namely a road-side unit (RSU), to authenticate the messages for the joining process. To cope with these issues, this paper proposes a provably secure efficient data-sharing scheme without RSU for 5G-enabled vehicular networks. Our work included six phases, namely: TA initialization (TASetup) phase, pseudonym-identity generation (PIDGen) phase, key generation (KeyGen) phase, message signing (MsgSign) phase, single verification (SigVerify) phase, and batch signatures verification (BSigVerify) phase. The vehicle in our work has the ability to verify multiple signatures simultaneously. Our work not only achieves privacy and security requirements but also withstands various security attacks on the vehicular network. Ultimately, our work also evaluates favourable performance compared to other existing schemes with regards to costs of communication and computation

Acceptance, Advocacy, and Perception of Health Care Providers on COVID-19 Vaccine: Comparing Early Stage of COVID-19 Vaccination with Latter Stage in the Eastern Region of Saudi Arabia

Vaccination of healthcare providers has recently gained focused attention of public health officials. As HCPs have direct contact with the population, and HCPs significantly influence the population, this study aimed to compare the acceptance rate, advocacy rate, and beliefs about the COVID-19 vaccine among HCPs in two time periods. In this repeated cross-sectional study, different HCPs were assessed in two periods ten months apart, i.e., November to December 2020 and September to October 2021, which were before and after COVID-19 vaccine approval by authorities. The study was conducted in Qatif Central Hospital, Eastern Region of Saudi Arabia. There were 609 respondents: 236 participants in the first period and 373 participants in the second period. Only 13 participants did not get the COVID-19 vaccine. There was around a 40% difference in the acceptance rate between the two study periods; the latter period was higher at 94.7%. Furthermore, 24.1% was the difference between the willingness to advocate the COVID-19 vaccine for others; the first period had a lower percentage (60.1%). Overall, results of the study showed that vaccine hesitancy, as well as the willingness to advocate for the vaccine, were improved between the pre-vaccine approval period and post-vaccine approval period, showing that the efforts made by the government improved COVID-19 acceptance and advocacy among HCPs. However, vaccine hesitancy is not a new issue, and for a better understanding of HCPs’ beliefs, a qualitative study is needed