6 research outputs found

    CD14 Deficiency Impacts Glucose Homeostasis in Mice through Altered Adrenal Tone

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    The toll-like receptors comprise one of the most conserved components of the innate immune system, signaling the presence of molecules of microbial origin. It has been proposed that signaling through TLR4, which requires CD14 to recognize bacterial lipopolysaccharide (LPS), may generate low-grade inflammation and thereby affect insulin sensitivity and glucose metabolism. To examine the long-term influence of partial innate immune signaling disruption on glucose homeostasis, we analyzed knockout mice deficient in CD14 backcrossed into the diabetes-prone C57BL6 background at 6 or 12 months of age. CD14-ko mice, fed either normal or high-fat diets, displayed significant glucose intolerance compared to wild type controls. They also displayed elevated norepinephrine urinary excretion and increased adrenal medullary volume, as well as an enhanced norepinephrine secretory response to insulin-induced hypoglycemia. These results point out a previously unappreciated crosstalk between innate immune- and sympathoadrenal- systems, which exerts a major long-term effect on glucose homeostasis

    Obituary: Peter Kelterborn (4 July 1928 – 9 March 2017)

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    On 9 March 2017, Peter Kelterborn, Swiss civil engineer and experimental archaeologist closed his eyes for good at the age of 89. He was known to many of his colleagues through his well-researched works on prehistorical flint and rock technology, but also from his methodological scientific experiments in archaeology. Many cherished him as a modest and thoughtful colleague, friend and counsellor

    Die neolithischen Dolche aus dem Kanton ZĂĽrich

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    Rohmaterial

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