Retroperitoneal Extragonadal Nonseminomatous Germ Cell Tumor with Synchronous Orbital Metastasis

A huge retroperitoneal tumor with a right orbital mass was detected and proved to be an extragonadal nonseminomatous germ cell tumor on biopsy. BEP chemotherapy caused some regression in orbital mass however no change in retroperitoneal tumor size as well as serum tumor marker levels occurred. Herein, we present a rarely seen entity of extragonadal retroperitoneal nonseminomatous germ cell tumor with synchronous orbital metastases and discuss its diagnosis and management

Treatment approaches to small renal masses in patients of advanced age (≥75 years).

The elderly population is increasing in Turkey and across the world. With the frequent use of imaging modalities, the detection rate of coincidental small renal mass has also increased. Since small renal masses are generally not malignant, most of them can be followed up by active surveillance. In the current study, we examined the treatment options that can be offered to elderly patients with small renal masses. The optimum treatment method for patients of advanced age presenting with renal masses should be determined based on the presence of comorbidities such as age, renal function, and tumor characteristics

Comparison of the oncological outcomes of patients who underwent radical and partial nephrectomy due to renal cell cancer

Amaç Bu çalışmada renal hücreli karsinom (RHK) nedeniyle radikal ve parsiyel nefrektomi yapılan hastaların evrelere göre onkolojik sonuçlarının karşılaştırılması amaçlanmıştır. Bu amaçla klinikopatolojik özelliklerin rekürrenssiz sağkalım ve kansere özgü sağkalım üzerine etkileri incelendi. ( Sakarya Tıp Dergisi 2019, 9(2):326-336 ) Gereç ve Yöntem 2004-2012 tarihleri arasında renal kitle nedeniyle kliniğimizde parsiyel/radikal nefrektomi uygulanan T3a ve altındaki 200 hastanın verilerini retrospektif olarak inceledik. Klinikopatolojik özelliklerin sağkalımlar üzerine istatistiksel etkileri olup olmadığı Log-Rank testi kullanılarak Kaplan Meier sağkalım analizi ile değerlendirildi. Her bir değişkene ilişkin 1- 3 ve 5 yıllık sağkalım hızları, ortalama yaşam süresi ve bu süreyle ilişkili %95 güven aralıkları hesaplandı. Bulgular Tüm olgular içerisinde 1- 3 ve 5 yıllık rekürrenssiz sağkalım % 95.5, 90.5 ve 85.5, kansere özgü sağkalım % 98.8, 96.4 ve 92.3 olarak tespit edildi. PN grubunda RN grubuna göre rekürrenssiz sağkalım istatistiksel olarak daha yüksekti (p=0,014) ama kansere özgü sağkalımda fark gözlenmedi. Evrelere göre T1a, T1b ve T3a’ da rekürrrenssiz sağkalım ve kansere özgü sağkalım T2a ve T2b’ den daha yüksekti (p=0,023 ve p<0,001). T1a ve T1b evrelerinde 1- 3 ve 5 yıllık rekürrenssiz sağkalım ve kansere özgü sağkalım benzer olarak bulundu ve klinikopatolojik özelliklerle istatistiksel olarak ilişki tespit edilmedi. Tüm olgular içerisinde patolojik tümör boyutu (p=0,026)’ nun rekürrenssiz sağkalımı etkilediği görüldü. Tüm olgular içerisinde multivariate analizlerde yaş (p=0,010) ve patolojik tümör boyutunun (p=0,018) kansere özgü sağkalımı etkilediği görüldü. Sonuç T1a ve T1b böbrek tümörlerinde parsiyel nefrektomi ve radikal nefrektomi yapılan hastalar arasında rekürrenssiz ve kansere özgü sağkalımların benzer olduğu gözlendi ve prognozunun herhangi bir klinikopatolojik özellikten etkilenmediği gözlendi. Klinikopatolojik ve demografik özelliklerin ileri evrelerde sağkalımla ilişkili olabileceği düşünüldü.Objective In this study, we aimed to compare the oncologic results of patients who underwent radical and partial nephrectomy due to renal cell carcinoma (RCC). The effects of clinicopathological features on recurrence-free survival and cancer-specific survival were investigated. ( Sakarya Med J 2019, 9(2):326-336 ). Materialsand Method We retrospectively analyzed the data of 200 patients who underwent partial / radical nephrectomy T3a and under between 2004-2012. Kaplan Meier survival analysis was used to evaluate the clinical effects of the clinicopathological features on survival by Log-Rank test. 1 - 3 and 5 - year survival rates, mean survival time and 95% confidence intervals for this time were calculated. Results When all the cases were evaluated, 1 - 3 and 5 - year recurrence - free survival was 95.5%, 90.5 and 85.5, cancer - specific survival was 98.8%, 96.4 and 92.3%. Recurrence-free survival between groups was statistically higher at PN (p = 0.014), but not differences were in cancer-specific survival. Recurrence-free and cancer-specific survival according to the stages was higher in T1a, T1b and T3a than T2a and T2b (p=0,023 ve p<0,001). 1- 3 and 5-year recurrence-free survival and cancer-specific survival were similar in T1a and T1b stages and this stages are not associated with clinicopathological features. In all cases of pathologic tumor size (p = 0.026) was observed to affect recurrence-free survival. In all cases multivariate analysis, of the age (p = 0.010) and pathological tumor size (p = 0.018) was observed to affect cancer-specific survival. Conclusion Recurrence-Free and Cancer-Specific Survival rates were similar between patients who underwent radical nephrectomy and partial nephrectomy for T1a and T1b renal cell carcinoma and was not affected by any of the clinicopathological prognostic feature. Clinicopathological and demographic characteristics may be associated with survival in advanced stages

Removing the specimen with traction during robotic radical prostatectomy does not cause a positive surgical margin

WOS: 000393331000007PubMed ID: 28081352Background/aim: The aim of this study was to gauge whether removal of a specimen with traction during robot-assisted laparoscopic radical prostatectomy causes a positive surgical margin or not. Materials and methods: One hundred and sixty-nine patients with localized prostate cancer who underwent robot-assisted laparoscopic radical prostatectomy from 2009 to 2011 were included in the study. After dividing the patients into two groups, we recorded their characteristics and pre-op/post-op evaluations. Results: There were 111 and 58 patients in groups 1 (with traction) and 2 (without traction), respectively. We evaluated the patients' ages, follow-up time, body mass index (BMI), prostate-specific antigen (PSA) values, pre-op and post-op Gleason score values, pathological stage, positive surgical margin rates, and biochemical PSA recurrence rates. There was no statistically significant difference between the groups for age, pre-op PSA values, BMI, pre-op and post-op Gleason scores, positive surgical margin rates and biochemical recurrence rates. There was a significant difference between prostate weight, tumor volume, and clinical stage. Conclusion: Removing the specimen with traction during robot-assisted laparoscopic radical prostatectomy does not cause a positive surgical margin. The incision should be as small as possible for cosmetic appearance