The diagnostic value of protein carbonyl levels in acute carbon monoxide intoxication

Tatli, Ozgur/0000-0003-0263-7630WOS: 000419631500004Objective: Carbon monoxide (CO) is the main cause of intoxication-related mortality and morbidity in developed countries. It is responsible for more than half of fatal intoxications in many countries. The purpose of this study was to determine the diagnostic value of protein carbonyl (PC), a good marker of oxidative stress, in association with oxidative stress resulting from hypoxia emerging in patients with acute CO intoxication. Methods: Thirty-four patients diagnosed with acute CO intoxication at the Emergency Department and 38 healthy volunteers were included in the study. Patients' PC levels at time of admission and after treatment were compared with those of a control group. Results: No statistically significant difference was observed among PC levels at time of admission in the patient and control groups (p = 0.305, patient group 0.025 +/- 0.01, control group 0.026 +/- 0.01). A significant decrease was determined in post-treatment PC levels in the patient group compared to those at time of admission (p = 0.006, admission 0.025 +/- 0.01, post-treatment 0.017 +/- 0.008). No significant correlation was determined between patients' carboxyhemoglobin (CO-Hb) levels and PC levels at time of admission (Correlation coefficient = -0.006, p= 0.971). Conclusions: We think that PC is not suitable for use as a biomarker in the acute period in patients with CO intoxication

The diagnostic value of protein carbonyl levels inAcute carbon monoxide intoxication

Amaç: Karbonmonoksit (CO) gelişmiş ülkelerde zehirlenme ile ilişkili mortalite ve morbiditenin ana nedenidir ve birçok ülkede ölümcül zehirlenmelerin yarısından fazlasından sorumlu tutulmaktadır. Bu çalışmada akut CO zehirlenmeli hastalarda meydana gelen hipoksi nedeniyle ortaya çıkan oksidatif strese bağlı olarak, iyi bir oksidatif stres markerı olan protein karbonilin (PC) tanısal değerini belirlemek amaçlanmıştır. Gereç ve Yöntem: Acil serviste CO zehirlenmesi tanısı alan 34 hasta ve sağlıklı 38 gönüllü çalışmaya alınmıştır. Hastaların başvuru anı ve tedavi sonrası PC seviyeleri, kontrol grubu ile karşılaştırılmıştır. Bulgular: Başvuru anında ortalama PC seviyeleri arasında hasta grubu ve kontrol grubu arasında istatistiksel olarak anlamlı fark tespit edilmemiştir, p 0.305 (hasta grubu 0.025 0.01, kontrol grup 0.026 0.01). Hasta grubunda tedavi sonrası PC seviyelerinde başvuru anına göre anlamlı bir düşüş tespit edilmiştir, p 0.006 (başvuru 0.025 0.01, tedavi sonrası 0.017 0.008). Hastalarda başvuru anında CO-Hb seviyeleri ile PC seviyeleri arasında istatistiksel olarak anlamlı bir korelasyon tespit edilmemiştir (Corelation coefficient -0.006, p 0.971). Sonuç: PC'nin CO zehirlenmeli hastalarda akut dönemde bir biyobelirteç olarak kullanılmasının uygun olmadığını düşünmekteyiz.Objective: Carbon monoxide (CO) is the main cause of intoxication-related mortality and morbidity in developed countries. It is responsible for more than half of fatal intoxications in many countries. The purpose of this study was to determine the diagnostic value of protein carbonyl (PC), a good marker of oxidative stress, in association with oxidative stress resulting from hypoxia emerging in patients with acute CO intoxication. Methods: Thirty-four patients diagnosed with acute CO intoxication at the Emergency Department and 38 healthy volunteers were included in the study. Patients' PC levels at time of admission and after treatment were compared with those of a control group. Results: No statistically significant difference was observed among PC levels at time of admission in the patient and control groups (p 0.305, patient group 0.025 ± 0.01, control group 0.026 ± 0.01). A significant decrease was determined in post-treatment PC levels in the patient group compared to those at time of admission (p 0.006, admission 0.025 ± 0.01, post-treatment 0.017 ± 0.008). No significant correlation was determined between patients' carboxyhemoglobin (CO-Hb) levels and PC levels at time of admission (Correlation coefficient -0.006, p 0.971). Conclusions: We think that PC is not suitable for use as a biomarker in the acute period in patients with CO intoxication