205 research outputs found
The synthesis and self-assembly studies of two bioactive BMP-7 short peptides modified rosette nanotubes for bone tissue engineering
Bone fractures are one of the most common bone complications. In more severe cases, bone fixation is accomplished using titanium (Ti) implant materials. Unfortunately, the need for revision surgery often arises due to implant loosening and/or deterioration of the implant/bone interface. Rosette nanotubes (RNTs) are a class of self-assembled organic materials obtained through the self-assembly of a guanine-cytosine hybrid base (G 27C motif). These organic materials have been found to increase osteoblast (bone forming cells) adhesion and hydroxyapatite deposition (bone regeneration) on titanium implants as well as on engineered hydrogels. In order to increase the bioactivity of RNTs to enhance bone cell function on Ti implants, two RNT motifs functionalized with different bioactive deca-peptides (A, B) chosen from the knuckle region of bone morphogenic proteins-7 (BMP-7) were synthesized. Their self-assembly process was investigated in water using UV-Vis and SEM techniques. \ua9 2011 Materials Research Society.Peer reviewed: YesNRC publication: Ye
Towards radiolabeled G 27C module for cellular imaging of bioactive Rosette nanotubes
Rosette nanotubes (RNTs) are obtained through the self-organization of biologically inspired self-complementary guanine-cytosine modules (G 27C motif) under physiological conditions. These architectures can express bioactive molecules on their surface by functionalizing the G 27C motif prior to self-assembly. As a result, RNTs are promising drug delivery vehicles for the treatment of diseases such as cancer and inflammatory disorders. Towards these studies, we have explored the toxicity and immunological response of RNTs and are now focused on understanding their cellular uptake, biological distribution and kinetics in vivo. For these investigations, we need to construct a RNT labeled with a radionuclide that can be followed in vivo by SPECT (single photon emission computed tomography) imaging. In this proceeding, we describe a twin G 27C motif that is functionalized with mercaptoacetyl triglycine (MAG 3). This is a well known ligand which is able to form a stable chelate with the radionuclides 99mTc or 186/188Re. In order to develop the chemistry for this radiolabeling strategy for the RNTs, we demonstrate the chelation of the MAG 3 functionalized twin-G 27C motif with cold rhenium and investigate the self-assembly properties of the complex into RNTs under aqueous conditions. \ua9 2011 Materials Research Society.Peer reviewed: YesNRC publication: Ye
Conformational analysis and inversion process in some perhydrodipyrido[1,2-b;1′2′-e]-1,4,2,5- dioxadiazines
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Tetraarylborate polymer networks as single-ion conducting solid electrolytes.
A new family of solid polymer electrolytes based upon anionic tetrakis(phenyl)borate tetrahedral nodes and linear bis-alkyne linkers is reported. Sonogashira polymerizations using tetrakis(4-iodophenyl)borate, tetrakis(4-iodo-2,3,5,6-tetrafluorophenyl)borate and tetrakis(4-bromo-2,3,5,6-tetrafluorophenyl)borate delivered highly cross-linked polymer networks with both 1,4-diethynylbeznene and a tri(ethylene glycol) substituted derivative. Promising initial conductivity metrics have been observed, including high room temperature conductivities (up to 2.7 × 10-4 S cm-1), moderate activation energies (0.25-0.28 eV), and high lithium ion transport numbers (up to tLi+ = 0.93). Initial investigations into the effects of important materials parameters such as bulk morphology, porosity, fluorination, and other chemical modification, provide starting design parameters for further development of this new class of solid electrolytes
Tetraarylborate polymer networks as single-ion conducting solid electrolytes
A new family of solid polymer electrolytes based upon anionic tetrakis(phenyl)borate tetrahedral nodes and linear bis-alkyne linkers is reported. Sonogashira polymerizations using tetrakis(4-iodophenyl)borate, tetrakis(4-iodo-2,3,5,6-tetrafluorophenyl)borate and tetrakis(4-bromo-2,3,5,6-tetrafluorophenyl)borate delivered highly cross-linked polymer networks with both 1,4-diethynylbeznene and a tri(ethylene glycol) substituted derivative. Promising initial conductivity metrics have been observed, including high room temperature conductivities (up to 2.7 × 10[superscript −4] S cm[superscript −1]), moderate activation energies (0.25–0.28 eV), and high lithium ion transport numbers (up to t[superscript Li+] = 0.93). Initial investigations into the effects of important materials parameters such as bulk morphology, porosity, fluorination, and other chemical modification, provide starting design parameters for further development of this new class of solid electrolytes
Benchmarking Micropollutant Removal by Activated Carbon and Porous β‑Cyclodextrin Polymers under Environmentally Relevant Scenarios
The
cost-effective and energy-efficient removal of organic micropollutants
(MPs) from water and wastewater is challenging. The objective of this
research was to evaluate the performance of porous β-cyclodextrin
polymers (P-CDP) as adsorbents of MPs in aquatic matrixes. Adsorption
kinetics and MP removal were measured in batch and flow-through experiments
for a mixture of 83 MPs at environmentally relevant concentrations
(1 μg L<sup>–1</sup>) and across gradients of pH, ionic
strength, and natural organic matter (NOM) concentrations. Performance
was benchmarked against a coconut-shell activated carbon (CCAC). Data
reveal pseudo-second-order rate constants for most MPs ranging between
1.5 and 40 g mg<sup>–1</sup> min<sup>–1</sup> for CCAC
and 30 and 40000 g mg<sup>–1</sup> min<sup>–1</sup> for
P-CDP. The extent of MP removal demonstrates slower but more uniform
uptake on CCAC and faster but more selective uptake on P-CDP. Increasing
ionic strength and the presence of NOM had a negative effect on the
adsorption of MPs to CCAC but had almost no effect on adsorption of
MPs to P-CDP. P-CDP performed particularly well for positively charged
MPs and neutral or negatively charged MPs with McGowan volumes greater
than 1.7 (cm<sup>3</sup> mol<sup>–1</sup>)/100. These data
highlight advantages of P-CDP adsorbents relevant to MP removal during
water and wastewater treatment
Cotton Fabric Functionalized with a β‑Cyclodextrin Polymer Captures Organic Pollutants from Contaminated Air and Water
Cotton
fabric is covalently functionalized with a porous β-cyclodextrin
polymer by including the fabric in the polymerization mixture. The
resulting functionalized fabric (CD-TFP@cotton) sequesters organic
micropollutants, such as bisphenol A, from water with outstanding
speed and a capacity 10-fold higher than that of untreated cotton.
The functionalized fabric also readily captures volatile organic compounds
(VOCs) from the vapor phase more quickly and with a capacity higher
than that of untreated cotton as well as three commercially available
fabric-based adsorbents. Volatile adsorbed pollutants were fully extracted
from CD-TFP@cotton under reduced pressure at room temperature, permitting
simple reuse. These properties make cotton functionalized with the
cyclodextrin polymer of interest for water purification membranes,
odor controlling fabrics, and respirators that control exposure to
VOCs. This functionalization approach is scalable, likely to be amenable
to other fibrous substrates, and compatible with existing fiber manufacturing
techniques
β‑Cyclodextrin Polymer Network Sequesters Perfluorooctanoic Acid at Environmentally Relevant Concentrations
Per- and poly fluorinated
alkyl substances (PFASs), notably perfluorooctanoic
acid (PFOA), contaminate many ground and surface waters and are environmentally
persistent. The performance limitations of existing remediation methods
motivate efforts to develop effective adsorbents. Here we report a
β-cyclodextrin (β-CD)-based polymer network with higher
affinity for PFOA compared to powdered activated carbon, along with
comparable capacity and kinetics. The β-CD polymer reduces PFOA
concentrations from 1 μg L<sup>–1</sup> to <10 ng
L<sup>–1</sup>, at least 7 times lower than the 2016 U.S. EPA
advisory level (70 ng L<sup>–1</sup>), and was regenerated
and reused multiple times by washing with MeOH. The performance of
the polymer is unaffected by humic acid, a component of natural organic
matter that fouls activated carbons. These results are promising for
treating PFOA-contaminated water and demonstrate the versatility of
β-CD-based adsorbents
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