A computational model of ureteral peristalsis and an investigation into ureteral reflux.

The aim of this study is to create a computational model of the human ureteral system that accurately replicates the peristaltic movement of the ureter for a variety of physiological and pathological functions. The objectives of this research are met using our in-house fluid-structural dynamics code (CgLes-Y code). A realistic peristaltic motion of the ureter is modelled using a novel piecewise linear force model. The urodynamic responses are investigated under two conditions of a healthy and a depressed contraction force. A ureteral pressure during the contraction shows a very good agreement with corresponding clinical data. The results also show a dependency of the wall shear stresses on the contraction velocity and it confirms the presence of a high shear stress at the proximal part of the ureter. Additionally, it is shown that an inefficient lumen contraction can increase the possibility of a continuous reflux during the propagation of peristalsis

Üreteropelvik bölge darlığında cajal hücreleri

TEZ7281Tez (Uzmanlık) -- Çukurova Üniversitesi, Adana, 2009.Kaynakça (s.61-69) var.viii, 70 s. : rnk.res. ; 29 cm.Aim: Cajal cells were described initially as a neuron like cells in the motor neuronal ends of the peripherally inervated organs. Recently, the number of investigations studying the localization and pathophysiology of Cajal cell's are increasing. Aim of this study is to investigate the ultrastructural forms and quantitative changes of Cajal cells, which are thought be responsible as a pacemaker in peristaltic activity of the ureter, in ureteropelvic junction obstruction, which is the most common cause of congenital hydronephrosis...Amaç: Son yıllarda ürogenital sistemdeki lokalizasyonları ve patofizyolojisine yönelik çalısmaların hız kazandıgı Cajal hücreleri, ilk defa periferal sinirlerle inerve edilen organların motor nöron sonlanmalarında, sinir hücresi benzeri hücreler seklinde tariflenmislerdir. Bu çalısmada konjenital hidronefrozun en sık nedeni olan üreteropelvik darlıkta, üreteral peristaltik aktiviteden sorumlu oldugu düsünülen Cajal hücrelerinin ultrastrukturel yapılarını ve kantitatif degisimlerini incelemeyi amaçladık. Materyal-Metod:Bu çalışma Ç.Ü. Bilimsel Araştırma Projeleri Birimi Tarafından Desteklenmiştir. Proje No:TF2006LTP1

High frequency voltage controlled ring oscillators in standard CMOS

Ph.D.Committee Chair: Martin A. Brook

Microdissection testicular sperm extraction (micro-TESE): Predictive value of preoperative hormonal levels and pathology in non-obstructive azoospermia

The aim of this study was to evaluate the predictive value of preoperative hormonal levels and pathology, as well as the outcome of microsurgical testicular sperm extraction in patients with non-obstructive azoospermia (NOA), presenting to our clinic for treatment of infertility. The records of 145 men with NOA who underwent microdissection testicular sperm extraction (micro-TESE) between March 2013 and November 2016 were studied. The patient's age, testicular volume, hormonal profile for follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone (TT), and testicular pathology were recorded. The sperm retrieval, the clinical pregnancy and live birth delivery rates were noted. Our testicular sperm retrieval rate was 65.5%. There was no statistical difference in age, testicular volume, or hormonal levels in the TESE-positive and negative groups. Hypospermatogenesis was found in testicular histopathology in 57 of 117 patients (48.7%) who underwent testicular biopsy. Sertoli Cell-Only (SCO) syndrome was seen in 20.5%, Germ Cell Maturation Arrest (MA) in 16.3%, and Atrophy-hyalinization in 14.5%. Seven men had Klinefelter's syndrome (KS), four of whom were TESE-positive. There were no adverse effects of the procedure except for infection at the incision site in one patient. Single intracytoplasmic sperm injection (ICSI) cycles were performed in 92 couples leading to 41 clinical pregnancies and 26 live birth deliveries. Micro-TESE is a safe procedure in experienced hands and provides infertile men with NOA an opportunity to father children. However unselected candidates with NOA should be counselled at the outset that only 17.9% will eventually become biological fathers

Use of regenerative treatments in dermatology

İstanbul Bilim Üniversitesi, Tıp Fakültesi.Son yıllarda rejeneratif tedaviler ile ilgili çalışmalarının sayısı büyük bir hızla artmaktadır. Bu tedavilerin Dermatoloji alanında kullanımları da dikkat çekici hale gelmiştir. Bu uygulamalar yara iyileşmesi, otoimmün ve enflamatuvar hastalıklar yanında kozmetik dalında da kullanılmaktadır. Bu baş döndürücü çalışmalar gelecekte birçok hastalıkta klasik kabul ettiğimiz tedavi yaklaşımlarının değişeceğinin sinyalini vermektedir. Bu yazıda Dermatoloji alanında rejeneratif tedavilerin kullanımından bahsedilmektedir.The number of studies on regenerative therapies has increased recently. Dermatological applications of such therapies have been quite interesting. Such applications include wound healing, auto-immune and inflammatory diseases as well as implementations in cosmetology. These outstanding studies signal that classical treatment approaches in many diseases are about to change. This article is about regenerative therapy applications in Dermatology

Hair cosmetics and camouflage technics

WOS: 000351336700016Hair is composed of a mixture of trace elements in small quantities, proteins, lipids and water. Proteins consist of helical polypeptide amino acid molecules. In the hair cells; polypeptide chains of keratin protein would be organized in filaments. In recent years, hair cosmetics showed a significant change and development. The content of shampoos which is used to cleanse the hair has enhanced significantly. Hair conditioner, hair styling products, pomades, brilliantine, and gloss sprays, hair protective products, camouflage products are most commonly used hair cosmetics. Hair shaping procedures are frequently applied

Platelet-rich plasma applications in dermatology

İstanbul Bilim Üniversitesi, Tıp Fakültesi.Trombositten zengin plazma büyüme faktörleri, sitokinler, kemokinler ve plazma proteinlerini içeren otolog biyoaktif bir üründür. Son yıllarda dermatolojide kullanımı giderek artmıştır. Önceleri kronik yara iyileşmesinde kullanılırken son yıllarda kozmetik dermatoloji alanında da kendine yer bulmuştur. Çoğu endikasyondaki kullanımı gelecekte ümit vermekle birlikte kontrollü, kanıta dayalı çalışmalara ihtiyaç vardır.Platelet-rich plasma is an autologous bioactive product, which contains growth factors, cytokines, chemokines, and plasma proteins. Its usage in dermatology has steadily increased in recent years. Previously used in chronic wound healing, it has found a niche in the field of cosmetic dermatology in recent years. Although it has promising usage in most indications, there is a need for controlled evidence-based studies

The Effect of Garlic Powder on Human Urinary Cytokine Excretion

WOS: 000332683000019PubMed ID: 24595942Purpose: To evaluate the effects of orally administered dehydrated garlic powder on cytokine excretion in the urinary tract. Materials and Methods: A total of 60 healthy volunteers, randomized into 3 groups, were given a single oral dose of 1 g or 3 g of dehydrated garlic powder or placebo. Urine samples were obtained 6.0 and 24.0 h after garlic intake and assayed for interleukin-8 (IL-8), interleukin-12 (IL-12), tumor necrosis factor-alpha (TNF-alpha), diallyl disulfide (DADS) and diallyl sulfide (DAS). Results: Significant increases in IL-12 levels over baseline were noted in urine samples obtained after oral intake of 1 g and 3 g of garlic powder (P .017). DADS and DAS were not detected in the urine samples at any time after garlic powder intake. Conclusion: Oral intake of doses of garlic traditionally used for daily supplementation increases urinary levels of IL-12, which is a potent stimulator of T helper cell 1 (Th-1) immune responses. This observation encourages further studies investigating the immunostimulatory role of garlic in the urinary tract

Laparoscopic partial nephrectomy in the treatment of kidney tumors

WOS: 000239906201650