A rare case report of primary renal squamous cell carcinoma

Primary renal squamous cell carcinoma is a very rare entity. Only few cases are reported in the world literature. Most of the patients present at a late stage resulting in poor prognosis. We report a 44 year old female who presented with a history of lump in right flank accompanied with a dull intermittent pain for 2 months duration which intensified in the last 15 days. Antecedent risk factors like renal calculi, analgesic use were absent. Computed Tomography (CT) examination revealed a mass arising from the superior pole of kidney with extension to the posterior segment of liver. Histopathology following nephrectomy showed histological features of well differentiated squamous cell carcinoma

Clinicopathological study of salivary gland tumors: An observation in tertiary hospital of central India

Background: The salivary glands are one of the few tissues in the body that are subjected to diverse and heterogeneous range of tumors and tumor like conditions. The relative infrequency of these tumors makes their diagnosis and management quite complicated. Fine needle aspiration cytology (FNAC) is a useful diagnostic procedure which has a recognized role in the evaluation of salivary gland lesions. A pre-operative diagnosis about nature of lesion, whether benign or malignant, will help in making decision about proper management of patient.Objective: Aim of this study was to know the epidemiology of salivary gland tumors in our region and to evaluate sensitivity, specificity and diagnostic accuracy of fine needle aspiration cytology taking histopathology as the gold standard. Method: It was prospective observational study conducted in department of pathology in our institute. Total 100 cases were studied with particular reference to age, sex, site, cytologic details & histological types as per WHO classification. FNAC & histopathological examination was done in all cases. Correlation between cytological & histopathological diagnoses was assessed. Diagnostic accuracy of FNAC was evaluated by comparing cytological & histopathological diagnoses.Results: Parotid gland was the most common site of involvement (70% cases). Maximum number of patients was in age range of 41-50 years & male to female ratio was 0.8:1. Most common benign & malignant tumors were pleomorphic adenoma (69.89% cases) & mucoepidermoid carcinoma (8.60% cases) respectively. On cytology, 93 cases while on histopathology 96 cases were diagnosed as neoplastic. Cytological diagnoses correlated with histopathological diagnoses in 94% cases. Sensitivity, specificity & diagnostic accuracy of FNAC were found to be 96.87%, 100% & 96% respectively. Conclusion: FNAC in salivary gland masses is fairly reliable for correct preoperative diagnosis. Multiple sampling and special attention to cytologic features should help to minimize errors.

A case of isolated eyelid cysticercosis masquerading as a dermoid cyst: histopathology to the rescue

Cysticercosis is a parasitic infection caused by larval form of Taenia Solium. The commonest site of cysticercosis is central nervous system followed by muscles, subcutaneous tissue and eyes. But only a handful of cases of eyelid cysticercosis have been reported in the literature. We report a case of isolated eyelid cysticercosis in a three year old female child who presented with swelling on the right upper eyelid which was clinically diagnosed as dermoid cyst because of its exclusive site of presentation. Histopathology of excised eyelid swelling revealed the diagnosis of cysticercosis

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly

Primitive neuroectodermal tumor presenting as a presacral mass: A rare case report with review of literature

Primitive neuroectodermal tumors (PNETs) are a group of highly malignant small round cell tumor (SRCT) of neuroectodermal origin. They exhibit a great diversity in their clinical manifestations and pathologic similarities with other SRCTs. PNET commonly occurs in the central nervous system, head and neck region, paravertebral region, pelvis, and lower extremities. PNET presenting as a presacral mass is very rare. We present a case of 65-year-old female patient presented with a mass in the abdomen. Exploratory laparotomy with excision of mass was carried out. Histopathology revealed the diagnosis of PNET. The rarity of PNET at presacral region prompted the description of this case

Cytology of lesions arising in and around operative scars: short series of four cases

Fine needle aspiration cytology (FNAC) is an established and valuable method for morphological diagnosis of soft tissue masses and confirmation of their local recurrence or metastasis. This study aims to highlight role of FNAC in confirmation of soft tissue recurrences that occurred in and around operative scars. Wet fixed & air dried smears were made from the material aspirated from four representative cases and stained routinely. Preoperative cytodiagnosis could be given in all cases. In two cases arising in previous scars of benign nerve sheath tumors, FNAC confirmed recurrence in one case and could suggest increased grade of lesion in the other. In the third case, in which initial nature of the lesion was not known, FNAC diagnosed scar endometriosis on two occasions. In fourth case local recurrence of extra abdominal fibromatosis was confirmed. Histopathological correlation was available in all cases. FNAC confirmed recurrence and could suggest diagnosis on scanty material

A case of isolated eyelid cysticercosis masquerading as a dermoid cyst: histopathology to the rescue

Cysticercosis is a parasitic infection caused by larval form of Taenia Solium. The commonest site of cysticercosis is central nervous system followed by muscles, subcutaneous tissue and eyes. But only a handful of cases of eyelid cysticercosis have been reported in the literature. We report a case of isolated eyelid cysticercosis in a three year old female child who presented with swelling on the right upper eyelid which was clinically diagnosed as dermoid cyst because of its exclusive site of presentation. Histopathology of excised eyelid swelling revealed the diagnosis of cysticercosis