1 research outputs found
The function of poliamine metabolism in prostate cancer
In many developed countries prostate cancer is the second leading cause of cancer related death in human population. Prostate tissue is characterized by the highest level of polyamines among organs in human body, and it is even higher in prostate carcinomas. These ubiquitous molecules are synthesized by prostate epithelium and are involved in many biochemical processes including cell proliferation, cell cycle regulation and protein synthesis. In this review we made the attempt to discuss the functions of polyamines, their involvement in apoptosis and potential role as molecular biomarker for prostate cancer. Also we present recent data on generation of drugs, in particular, cyclin dependent kinase inhibitor, developed for therapy of prostate cancer.ΠΠΎ ΠΌΠ½ΠΎΠ³ΠΈΡ
ΡΠ°Π·Π²ΠΈΡΡΡ
ΡΡΡΠ°Π½Π°Ρ
ΡΠ°ΠΊ ΠΏΡΠ΅Π΄ΡΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ Π·Π°Π½ΠΈΠΌΠ°Π΅Ρ ΠΏΠ΅ΡΠ²ΠΎΠ΅ ΠΌΠ΅ΡΡΠΎ ΠΊΠ°ΠΊ ΠΏΡΠΈΡΠΈΠ½Π° ΡΠΌΠ΅ΡΡΠ½ΠΎΡΡΠΈ Π²ΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠ΅
ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ. Π’ΠΊΠ°Π½Ρ ΠΏΡΠ΅Π΄ΡΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΠ΅ΡΡΡ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π²ΡΡΠΎΠΊΠΈΠΌ ΡΡΠΎΠ²Π½Π΅ΠΌ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ
ΠΏΠΎΠ»ΠΈΠ°ΠΌΠΈΠ½ΠΎΠ² Π² ΡΡΠ°Π²Π½Π΅Π½ΠΈΠΈ Ρ Π΄ΡΡΠ³ΠΈΠΌΠΈ ΠΎΡΠ³Π°Π½Π°ΠΌΠΈ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°, ΠΏΡΠΈΡΠ΅ΠΌ Π² ΡΠΊΠ°Π½ΠΈ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ ΠΏΡΠΎΡΡΠ°ΡΡ ΠΈΡ
ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ Π΅ΡΠ΅ Π²ΡΡΠ΅. ΠΡΠΈ
Π±ΠΈΠΎΠΌΠΎΠ»Π΅ΠΊΡΠ»Ρ ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΡΡΡΡΡ ΡΠΏΠΈΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΡΠΌΠΈ ΠΊΠ»Π΅ΡΠΊΠ°ΠΌΠΈ ΠΏΡΠ΅Π΄ΡΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ ΠΈ ΠΏΡΠΈΠ½ΠΈΠΌΠ°ΡΡ ΡΡΠ°ΡΡΠΈΠ΅ Π²ΠΎ ΠΌΠ½ΠΎΠ³ΠΈΡ
Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠ°Ρ
, Π²ΠΊΠ»ΡΡΠ°Ρ ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ, ΡΠ΅Π³ΡΠ»ΡΡΠΈΡ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠΈΠΊΠ»Π° ΠΈ ΡΠΈΠ½ΡΠ΅Π· Π±Π΅Π»ΠΊΠΎΠ². Π ΠΎΠ±Π·ΠΎΡΠ΅ ΠΎΠ±ΡΡΠΆΠ΄Π°ΡΡΡΡ ΡΡΠ½ΠΊΡΠΈΠΈ
ΠΏΠΎΠ»ΠΈΠ°ΠΌΠΈΠ½ΠΎΠ² Π² ΠΊΠ»Π΅ΡΠΊΠ΅, ΠΈΡ
ΡΡΠ°ΡΡΠΈΠ΅ Π² ΠΏΡΠΎΡΠ΅ΡΡΠ°Ρ
Π°ΠΏΠΎΠΏΡΠΎΠ·Π° ΠΈ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½Π°Ρ ΡΠΎΠ»Ρ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π±ΠΈΠΎΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² ΠΏΡΠΈ ΡΠ°ΠΊΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠΉ
ΠΆΠ΅Π»Π΅Π·Ρ. ΠΡΠΎΠΌΠ΅ ΡΠΎΠ³ΠΎ, ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Ρ Π½ΠΎΠ²ΡΠ΅ Π΄Π°Π½Π½ΡΠ΅ ΠΎ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ΅ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ², Π² ΡΠ°ΡΡΠ½ΠΎΡΡΠΈ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΠ° ΡΠΈΠΊΠ»ΠΈΠ½Π·Π°Π²ΠΈΡΠΈΠΌΠΎΠΉ ΠΊΠΈΠ½Π°Π·Ρ,
ΠΏΡΠ΅Π΄Π½Π°Π·Π½Π°ΡΠ΅Π½Π½ΡΡ
Π΄Π»Ρ Π»Π΅ΡΠ΅Π½ΠΈΡ ΡΠ°ΠΊΠ° ΠΏΡΠ΅Π΄ΡΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ