Cross-Sectional and Longitudinal Effects of Glycemic Status on Body Composition, Bone, and Lipid Profile in Men Aged 20 to 66 Years: A Population-Based Study

Pre-diabetes and type 2 diabetes (T2D) are significant public health challenges in the United States. Pre-diabetes and T2D are a multi-factorial disease characterized by genetic or environmental factors or a combination of both. There has been an upward trend over time in the prevalence of both pre-diabetes and T2D. Few epidemiological studies exist regarding the effect of baseline glycemic status on changes in body composition, bone health, and lipid profiles. To fill this critical gap, the purpose of this research was to examine both cross-sectional and longitudinal changes in glycemic status with changes in body composition, bone mass and density, and lipid profile and cardiovascular risk ratios in men aged 20 to 66 years. This dissertation uses data from the South Dakota Rural Bone Health Study, a population-based longitudinal study designed to investigate the impact of lifestyle factors on bone and body composition. Findings from this study provide insight into the adverse effect of changes in glycemic status on total and regional body composition and bone health. Creating prevention strategies targeted at individuals affected by, or at risk of, pre-diabetes and T2D, such as promoting a healthy diet, physical activity, and weight loss may reverse the unfavorable effects of pre-diabetes and T2D

Cross-Sectional and Longitudinal Association between Glycemic Status and Body Composition in Men: A Population-Based Study

This study sought to evaluate the associations between changes in glycemic status and changes in total body (TB), trunk, and appendicular fat (FM) and lean mass (LM) in men. A population-based study of men aged 20–66 years at baseline were included in cross-sectional (n = 430) and three-year longitudinal (n = 411) analyses. Prediabetes was defined as fasting glucose 100–125 mg/dL. Type 2 diabetes (T2D) was determined by: self-reported diabetes, current anti-diabetic drug use (insulin/oral hypoglycemic agents), fasting glucose (≥126 mg/dL), or non-fasting glucose (≥200 mg/dL). Body composition was evaluated by dual-energy X-ray absorptiometry. Longitudinal analyses showed that changes in TB FM and LM, and appendicular LM differed among glycemic groups. Normoglycemic men who converted to prediabetes lost more TB and appendicular LM than men who remained normoglycemic (all, p \u3c 0.05). Normoglycemic or prediabetic men who developed T2D had a greater loss of TB and appendicular LM than men who remained normoglycemic (both, p \u3c 0.05). T2D men had greater gains in TB FM and greater losses in TB and appendicular LM than men who remained normoglycemic (all, p \u3c 0.05). Dysglycemia is associated with adverse changes in TB and appendicular LM