Control of the cation occupancies of MnZn ferrite synthesized via reverse micelles

Variations in cation occupancy in mixed metal ferrite systems can affect their electronic and magnetic properties. It is known that different synthesis parameters can lead to various cation distributions and the ability to tune these distributions is of great interest. This study uses the extended x-ray-absorption fine structure–IR relationship to investigate the effect of various Fe2+/Fe3+ ratios in initial synthesis conditions on cation distribution for manganesezincferrite (MZFO). Differences in the precipitated material before firing could lead to differences in the final material if fired under similar conditions. This work uses several different ratios of Fe3+/Fe2+, which will affect the initial cell potential for the reaction, to synthesize nano MZFO. All samples were fired for 5h at 500°C under flowing nitrogen. Transmission electron microscopy micrographs reveal highly crystalline uniform nanoparticles of 16±2nm. The x-ray diffraction revealed single phase crystalline MZFO with an average crystallite size of around 14nm. The saturation magnetization ranged from 43to68emu∕g as measured by vibrating-sample magnetometry. The Fourier transform infrared (FTIR) analysis was used to determine the cation occupancies while changing the initial Fe3+/Fe2+ ratios from 10∕90 to90∕10. The FTIRspectra revealed a shift in the first absorption region in the far IR from 566.98to549.62cm−1 corresponding to the octahedral occupancies. This shift corresponds to a change in the percentage of octahedral sites occupied by manganese from roughly 25% to 12%. This change in manganese occupancy is also observed in the iron occupancies, which in turn help to explain the variation in saturation magnetization

The hemostatic effects of acute exposure to colored cornstarch powder during a 5k run

PURPOSE: To examine the acute hemostatic effects of particulate matter (PM) in the form of colored corn starch powder during a 5 kilometer race. METHODS: 10 recreationally active adults completed two 5k runs, one with color and one without color. 10 mL blood samples were taken 6 hours prior to the trial and immediately following the trial. PAI-1 activity, FVIII antigen, and tPA activity were measured using an ELISA. RESULTS: No significant main effects or interaction effects (P\u3c0.05) were observed among any of the variables although a trend (P = 0.082) was observed for increased PAI-1 activity during exercise in the color condition. CONCLUSIONS: There is a trend towards increased PAI-1 activity levels during exercise during color runs that could be due to increased inflammation. Furthermore, the lack of increased FVIII:ag and tPA activity suggests that the intensity of the exercise may not have been adequate and further research should be conducted in this area

Moral Dilemmas: A Phenomenological Exploration of Military Members Experience of War

Due to increasing mental health concerns in combat exposed military members, including posttraumatic stress, there is a commiserate need for improved mental health services. Other mental health concerns include an increasing rate of suicide deaths in military members who have served during Operation Enduring Freedom (OEF), or Operation Iraqi Freedom (OIF). There is a need for mental health counselors to have a more nuanced understanding of the clinical needs of combat exposed military members. In more recent years the construct of moral injury has emerged as a potential explanation for the presentation of certain combat exposed military members. Moral injury can be thought of as the social, spiritual, psychological, emotional, and existential wound that can occur in the aftermath of either doing or witnessing acts that are contrary to the individual’s moral belief system. The purpose of this phenomenological study is to gain an understanding of how moral injury might better explain the clinical presentation of certain traumatized military members. This study seeks to add to a growing body of knowledge surrounding the construct of moral injury as it pertains to certain combat exposed military members presenting with trauma symptoms. Participants will have deployed to a combat zone during either the Gulf War or OEF / OIF and will have held a job within the military (military occupational specialty; MOS) commonly associated with combat exposure (e.g. reconnaissance)

A Proactive Abortion Agenda: Federal and State Policies To Protect and Expand Access

This report outlines federal- and state-level policy recommendations to advance abortion rights and access. Where relevant, the authors offer international and domestic examples of countries and states working to make abortion access meaningful for everyone—and highlight the advocacy of other organizations and providers to achieve some of these policies. Some recommendations have been covered in previous reports from the Center for American Progress, as well as other federal and state organizations leading on various issues; but the objective here is to provide a comprehensive road map for state and federal lawmakers to develop and enact policies that achieve equitable abortion access

TRIPTOLIDE IS A POTENTIAL THERAPEUTIC AGENT FOR ALZHEIMER’S DISEASE

Mounting evidence indicates an involvement of inflammation in the pathogenesis of Alzheimer’s disease. While there are other mechanisms involved, it is this role of inflammatory processes that we wish to investigate. Triptolide is the major constituent in the Chinese herb, Tripterygium wilfordii Hook F, and has been used for centuries as part of Chinese herbal medicine. The four ringed structure has close homology to drugs of the steroid class and it has been shown to be beneficial as an anti-inflammatory for rheumatoid arthritis and for treatment of certain cancers. The aim of this study was to evaluate the potential therapeutic effect of Triptolide on the neuropathology and deficits of spatial 6 learning and memory in amyloid precursor protein (APP) and presenilin 1 (PS1) doubletransgenic mice, a well established Alzheimer’s disease (AD) mouse model. After treatment of APP/PS1 mice with Triptolide (40μg/kg, three times weekly,), initiated when the mice were 5 months old, for as little as 8 weeks, significant decrease in β-amyloid (Aβ) deposition and microglia activation was observed. Moreover, Triptolide treatment robustly rescued spatial memory deficits observed in APP/PS1 mice. However, APP processing, tau hyperphosphorylation, and the activities of the two major kinases involved in tau hyperphosphorylation, cyclin dependent kinase 5 (cdk5) and glycogen synthase kinase 3β (GSK3β) were not affected by the Triptolide treatment. Based on the recent finding for the inhibitory effect of Triptolide on Aβ-induced production of pro-inflammatory cytokines from microglia, we propose that Triptolide treatment may have beneficial properties in halting glial activation and help restore an immune system that fights plaque deposition. Although the exact mechanism of action has yet to be deduced, the increase in APP CTFs while having a significant decrease in amyloid plaque deposition suggests that alterations in gamma secretase activity may be a possible answer. Currently, these results support the use of Triptolide as an effective therapeutic to prevent the progression of Alzheimer’s disease

Segmentation of epidermal tissue with histopathological damage in images of haematoxylin and eosin stained human skin.

Background: Digital image analysis has the potential to address issues surrounding traditional histological techniques including a lack of objectivity and high variability, through the application of quantitative analysis. A key initial step in image analysis is the identification of regions of interest. A widely applied methodology is that of segmentation. This paper proposes the application of image analysis techniques to segment skin tissue with varying degrees of histopathological damage. The segmentation of human tissue is challenging as a consequence of the complexity of the tissue structures and inconsistencies in tissue preparation, hence there is a need for a new robust method with the capability to handle the additional challenges materialising from histopathological damage.Methods: A new algorithm has been developed which combines enhanced colour information, created following a transformation to the L*a*b* colourspace, with general image intensity information. A colour normalisation step is included to enhance the algorithm's robustness to variations in the lighting and staining of the input images. The resulting optimised image is subjected to thresholding and the segmentation is fine-tuned using a combination of morphological processing and object classification rules. The segmentation algorithm was tested on 40 digital images of haematoxylin & eosin (H&E) stained skin biopsies. Accuracy, sensitivity and specificity of the algorithmic procedure were assessed through the comparison of the proposed methodology against manual methods.Results: Experimental results show the proposed fully automated methodology segments the epidermis with a mean specificity of 97.7%, a mean sensitivity of 89.4% and a mean accuracy of 96.5%. When a simple user interaction step is included, the specificity increases to 98.0%, the sensitivity to 91.0% and the accuracy to 96.8%. The algorithm segments effectively for different severities of tissue damage.Conclusions: Epidermal segmentation is a crucial first step in a range of applications including melanoma detection and the assessment of histopathological damage in skin. The proposed methodology is able to segment the epidermis with different levels of histological damage. The basic method framework could be applied to segmentation of other epithelial tissues

Surgical Education in the 21st Century

Surgical education has evolved drastically since the 19th century. Previously education of surgical residents was limited to on job clinical training following the “see one, do one, teach one” model with knowledge gleaned from textbooks and journals. Presently a growing emphasis has been placed on both patient safety and resident well-being leading to a development of novel training paradigms. The textbook, while remaining a core source of knowledge, is now only one of many resources available to residents. Many residencies have their libraries online, making learning possible almost anywhere, even without physical books in hand. Most programs now incorporate education days where a structured curriculum allows for standardized education; this makes it less likely that residents miss out on mandatory concepts. The 2020 Covid-19 pandemic has led to further evolution of this model, making the classroom virtual yet interactive. Technology has allowed for residents to train on surgical simulators, so that laparoscopic and robotic skills may be practiced before application on a live patient. Altogether residents are afforded multiple ways to learn due to greater availability of time, structured educational modules, and technology

Does true Gleason pattern 3 merit its cancer descriptor?

Nearly five decades following its conception, the Gleason grading system remains a cornerstone in the prognostication and management of patients with prostate cancer. In the past few years, a debate has been growing whether Gleason score 3 + 3 = 6 prostate cancer is a clinically significant disease. Clinical, molecular and genetic research is addressing the question whether well characterized Gleason score 3 + 3 = 6 disease has the ability to affect the morbidity and quality of life of an individual in whom it is diagnosed. The consequences of treatment of Gleason score 3 + 3 = 6 disease are considerable; few men get through their treatments without sustaining some harm. Further modification of the classification of prostate cancer and dropping the label cancer for Gleason score 3 + 3 = 6 disease might be warranted

Body mass index does not predict injury pattern or outcome after motorcycle crash

Introduction: The obesity epidemic plagues the United States, affecting approximately 42% of the population. The relationship of obesity with injury severity and outcomes has been poorly studied among motorcycle collisions (MCC). This study aimed to compare injury severity, mortality, injury regions, and hospital and intensive care unit length of stay (LOS) between obese and normal-weight MCC patients. Methods: Trauma registries from three Pennsylvania Level 1 trauma centers were queried for adult MCC patients (January 1, 2016-December 31, 2020). Obesity was defined as adult patients with body mass index 30 kg/m2 and normal weight was defined as body mass index/m2 but \u3e18.5 kg/m2. Demographics and injury characteristics including injury severity score (ISS), abbreviated injury score, mortality, transfusions and LOS were compared. P≤0.05 was considered significant. Results: One thousand one hundred sixty-four patients met the inclusion criteria: 40% obese (n=463) and 60% nonobese (n=701). Comparison of ISS demonstrated no statistically significant difference between obese and normal-weight patients with median ISS (interquartile range) 9 (5-14) versus 9 (5-14), respectively (P=0.29). Obese patients were older with median age 45 (32-55) years versus 38 (26-54) years, respectively (P Conclusions: Obese patients experiencing MCC had no differences in distribution of injury, mortality, or injury severity, mortality, injury regions, and hospital compared to normal weight adults. Our study differs from current data that obese motorcycle drivers may have different injury characteristics and increased LOS