Probing the cool ISM in galaxies via 21cm HI absorption

Recent targeted studies of associated HI absorption in radio galaxies are starting to map out the location, and potential cosmological evolution, of the cold gas in the host galaxies of Active Galactic Nuclei (AGN). The observed 21 cm absorption profiles often show two distinct spectral-line components: narrow, deep lines arising from cold gas in the extended disc of the galaxy, and broad, shallow lines from cold gas close to the AGN (e.g. Morganti et al. 2011). Here, we present results from a targeted search for associated HI absorption in the youngest and most recently-triggered radio AGN in the local universe (Allison et al. 2012b). So far, by using the recently commissioned Australia Telescope Compact Array Broadband Backend (CABB; Wilson et al. 2011), we have detected two new absorbers and one previously-known system. While two of these show both a broad, shallow component and a narrow, deep component (see Fig. 1), one of the new detections has only a single broad, shallow component. Interestingly, the host galaxies of the first two detections are classified as gas-rich spirals, while the latter is an early-type galaxy. These detections were obtained using a spectral-line finding method, based on Bayesian inference, developed for future large-scale absorption surveys (Allison et al. 2012a).Comment: 1 page, 1 figure, published in Proceedings of IAU Symposium No. 29

Fish -- More Than Just Another Commodity

This brief highlights the contribution of wild capture fisheries to nutritional security in fish dependent developing countries. It is intended to stimulate debate around two broad themes: (1) when should the focus of fisheries policies be on local food security and human well-being as opposed to revenue generation, and (2) how does the current research agenda, with its emphasis on environmental and economic issues, assist or impair decision making processes

An assessment of scup (Stenotomus chrysops) and black sea bass (Centropristas striata) discards in the directed otter trawl fisheries in the Mid-Atlantic Bight

This study was undertaken to re-assess the level of scup (Stenotomus chrysops) discards by weight and to evaluate the effect of various codend mesh sizes on the level of scup discards in the winter-trawl scup fishery. Scup discards were high in directed scup tows regardless of codend mesh — typically one to five times the weight of landings. The weight of scup discards in the present study did not differ significantly from that recorded in scup-targeted tows in the NMFS observer database. Most discards were required as such by the 22.86 cm TL (total length) fish-size limit for catches. Mesh sizes ≤12.7 cm, including the current legal mesh size (11.43 cm) did not adequately filter out scup smaller than 22.86 cm. The median length of scup discards was about 19.83 cm TL. Lowering the legal size for scup from 22.86 to 19.83 cm TL would greatly reduce discard mortality. Scup discards were a small fraction (0.4%) of black sea bass (Centropristis striata) landings in blacksea-bass−targeted tows. The black sea bass fishery is currently regulated under the small-mesh fishery gearrestricted area plan in which fishing is prohibited in some areas to reduce scup mortality. Our study found no evidence to support the efficacy of this management approach. The expectations that discarding would increase disproportionately as the trip limit (limit [in kilograms] on catch for a species) was reached towards the end of the trip and that discards would increase when the trip limit was reduced from 4536 kg to 454 kg at the end of the directed fishing season were not supported. Trip limits did not significantly affect discard mortality

Mesenchymal Stem Cell Spheroids Retain Osteogenic Phenotype Through α2β1 Signaling.

Unlabelled: The induction of mesenchymal stem cells (MSCs) toward the osteoblastic lineage using osteogenic supplements prior to implantation is one approach under examination to enhance their bone-forming potential. MSCs rapidly lose their induced phenotype upon removal of the soluble stimuli; however, their bone-forming potential can be sustained when provided with continued instruction via extracellular matrix (ECM) cues. In comparison with dissociated cells, MSC spheroids exhibit improved survival and secretion of trophic factors while maintaining their osteogenic potential. We hypothesized that entrapment of MSC spheroids formed from osteogenically induced cells would exhibit better preservation of their bone-forming potential than would dissociated cells from monolayer culture. Spheroids exhibited comparable osteogenic potential and increased proangiogenic potential with or without osteogenic preconditioning versus monolayer-cultured MSCs. Spheroids were then entrapped in collagen hydrogels, and the osteogenic stimulus was removed. In comparison with entrapped dissociated MSCs, spheroids exhibited significantly increased markers of osteogenic differentiation. The capacity of MSC spheroids to retain their osteogenic phenotype upon withdrawal of inductive cues was mediated by α2β1 integrin binding to cell-secreted ECM. These results demonstrate the capacity of spheroidal culture to sustain the mineral-producing phenotype of MSCs, thus enhancing their contribution toward bone formation and repair.SignificanceDespite the promise of mesenchymal stem cells (MSCs) for cell-based therapies for tissue repair and regeneration, there is little evidence that transplanted MSCs directly contribute to new bone formation, suggesting that induced cells rapidly lose their osteogenic phenotype or undergo apoptosis. In comparison with dissociated cells, MSC spheroids exhibit increased trophic factor secretion and improved cell survival. The loss of phenotype represents a significant clinical challenge for cell therapies, yet there is no evidence for whether MSC spheroids retain their osteogenic phenotype upon entrapment in a clinically relevant biomaterial. These findings demonstrate that MSC spheroids retain their osteogenic phenotype better than do dissociated MSCs, and this is due to integrin engagement with the cell-secreted extracellular matrix. These data provide evidence for a novel approach for potentiating the use of MSCs in bone repair

The Interaction of Diet and Mitochondrial Dysfunction in Aging and Cognition

Aging is inevitable and it is one of the major contributors to cognitive decline. However, the mechanisms underlying age-related cognitive decline are still the object of extensive research. At the biological level, it is unknown how the aging brain is subjected to progressive oxidative stress and neuroinflammation which determine, among others, mitochondrial dysfunction. The link between mitochondrial dysfunction and cognitive impairment is becoming ever more clear by the presence of significant neurological disturbances in human mitochondrial diseases. Possibly, the most important lifestyle factor determining mitochondrial functioning is nutrition. Therefore, with the present work, we review the latest findings disclosing a link between nutrition, mitochondrial functioning and cognition, and pave new ways to counteract cognitive decline in late adulthood through diet

P1–222: ApoE4 lipoprotein 4 reduces risk of dementia from high sensitivity C–reactive protein

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/152633/1/alzjjalz200605599.pd

Shape of the 8B Alpha and Neutrino Spectra

The beta-delayed alpha spectrum from the decay of 8B has been measured with a setup that minimized systematic uncertainties that affected previous measurements. Consequently the deduced neutrino spectrum presents much smaller uncertainties than the previous recommendation. The 8B neutrino spectrum is found to be harder than previously recommended with about (10-20)% more neutrinos at energies between 12-14 MeV. The efficiencies of the 37Cl, 71Ga, 40Ar, and SuperKamiokande detectors are respectively, 3.6%, 1.4%, 5.7% and 1.8% larger than previously thought.Comment: 4 pages, 5 figure