Pole dynamics for the Flierl-Petviashvili equation and zonal flow

We use a systematic method which allows us to identify a class of exact solutions of the Flierl-Petvishvili equation. The solutions are periodic and have one dimensional geometry. We examine the physical properties and find that these structures can have a significant effect on the zonal flow generation.Comment: Latex 40 pages, seven figures eps included. Effect of variation of g_3 is studied. New references adde

Patient participation in general practice-based undergraduate teaching: a focus group study of patient perspectives

Background: Patients make a crucial contribution to undergraduate medical education. While a national resource is available for patients participating in research, none is at yet available for education. / Aim: This study aimed to explore what information patients would like about participation in general practice-based undergraduate medical education and how they would like to obtain this information. / Design and Setting: We conducted two focus groups in London-based practices involved in both undergraduate and postgraduate teaching. / Method: Patients were recruited both with and without teaching experience using leaflets, posters and patient participation groups. An open-ended topic guide explored three areas: perceived barriers which participants anticipated, or had experienced; patient roles in medical education; and what help would support participation. Focus groups were audio-taped, transcribed and analysed thematically. / Results: Patients suggested ways of professionalising the teaching process, making information available to patients about confidentiality; iterative consent; and normalising teaching in the practice. Patients highlighted the importance of relationships: making information available about their GP’s involvement, and initiating student-patient interactions. Participants emphasised educational principles to maximise exchange of information including active participation of students; patient identification of student learner needs; and exchange of feedback. / Conclusion: This study will inform development of patient information resources to support their participation in teaching and access to information both before and during general practicebased teaching encounters

Mapping Dynamic Histone Acetylation Patterns to Gene Expression in Nanog-depleted Murine Embryonic Stem Cells

Embryonic stem cells (ESC) have the potential to self-renew indefinitely and to differentiate into any of the three germ layers. The molecular mechanisms for self-renewal, maintenance of pluripotency and lineage specification are poorly understood, but recent results point to a key role for epigenetic mechanisms. In this study, we focus on quantifying the impact of histone 3 acetylation (H3K9,14ac) on gene expression in murine embryonic stem cells. We analyze genome-wide histone acetylation patterns and gene expression profiles measured over the first five days of cell differentiation triggered by silencing Nanog, a key transcription factor in ESC regulation. We explore the temporal and spatial dynamics of histone acetylation data and its correlation with gene expression using supervised and unsupervised statistical models. On a genome-wide scale, changes in acetylation are significantly correlated to changes in mRNA expression and, surprisingly, this coherence increases over time. We quantify the predictive power of histone acetylation for gene expression changes in a balanced cross-validation procedure. In an in-depth study we focus on genes central to the regulatory network of Mouse ESC, including those identified in a recent genome-wide RNAi screen and in the PluriNet, a computationally derived stem cell signature. We find that compared to the rest of the genome, ESC-specific genes show significantly more acetylation signal and a much stronger decrease in acetylation over time, which is often not reflected in an concordant expression change. These results shed light on the complexity of the relationship between histone acetylation and gene expression and are a step forward to dissect the multilayer regulatory mechanisms that determine stem cell fate.Comment: accepted at PLoS Computational Biolog

An NLO QCD analysis of inclusive cross-section and jet-production data from the ZEUS experiment

The ZEUS inclusive differential cross-section data from HERA, for charged and neutral current processes taken with e+ and e- beams, together with differential cross-section data on inclusive jet production in e+ p scattering and dijet production in \gamma p scattering, have been used in a new NLO QCD analysis to extract the parton distribution functions of the proton. The input of jet data constrains the gluon and allows an accurate extraction of \alpha_s(M_Z) at NLO; \alpha_s(M_Z) = 0.1183 \pm 0.0028(exp.) \pm 0.0008(model) An additional uncertainty from the choice of scales is estimated as \pm 0.005. This is the first extraction of \alpha_s(M_Z) from HERA data alone.Comment: 37 pages, 14 figures, to be submitted to EPJC. PDFs available at http://durpdg.dur.ac.uk/hepdata in LHAPDFv