14,914 research outputs found
Micro-Structured Ferromagnetic Tubes for Spin Wave Excitation
Micron scale ferromagnetic tubes placed on the ends of ferromagnetic CoTaZr
spin waveguides are explored in order to enhance the excitation of Backward
Volume Magnetostatic Spin Waves. The tubes produce a closed magnetic circuit
about the signal line of the coplanar waveguide and are, at the same time,
magnetically contiguous with the spin waveguide. This results in a 10 fold
increase in spin wave amplitude. However, the tube geometry distorts the
magnetic field near the spin waveguide and relatively high biasing magnetic
fields are required to establish well defined spin waves. Only the lowest
(uniform) spin wave mode is excited.Comment: 3 pages, 3 figure
Migration paths saturations in meta-epidemic systems
In this paper we consider a simple two-patch model in which a population
affected by a disease can freely move. We assume that the capacity of the
interconnected paths is limited, and thereby influencing the migration rates.
Possible habitat disruptions due to human activities or natural events are
accounted for. The demographic assumptions prevent the ecosystem to be wiped
out, and the disease remains endemic in both populated patches at a stable
equilibrium, but possibly also with an oscillatory behavior in the case of
unidirectional migrations. Interestingly, if infected cannot migrate, it is
possible that one patch becomes disease-free. This fact could be exploited to
keep disease-free at least part of the population
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Enhanced anticancer activity of a combination of docetaxel and Aneustat (OMN54) in a patient-derived, advanced prostate cancer tissue xenograft model.
The current first-line treatment for advanced metastatic prostate cancer, i.e. docetaxel-based therapy, is only marginally effective. The aim of the present study was to determine whether such therapy can be improved by combining docetaxel with Aneustat (OMN54), a multivalent botanical drug candidate shown to have anti-prostate cancer activity in preliminary in vitro experiments, which is currently undergoing a Phase-I Clinical Trial. Human metastatic, androgen-independent C4-2 prostate cancer cells and NOD-SCID mice bearing PTEN-deficient, metastatic and PSA-secreting, patient-derived subrenal capsule LTL-313H prostate cancer tissue xenografts were treated with docetaxel and Aneustat, alone and in combination. In vitro, Aneustat markedly inhibited C4-2 cell replication in a dose-dependent manner. When Aneustat was combined with docetaxel, the growth inhibitions of the drugs were essentially additive. In vivo, however, the combination of docetaxel and Aneustat enhanced anti-tumor activity synergistically and very markedly, without inducing major host toxicity. Complete growth inhibition and shrinkage of the xenografts could be obtained with the combined drugs as distinct from the drugs on their own. Analysis of the gene expression of the xenografts using microarray indicated that docetaxel + Aneustat led to expanded anticancer activity, in particular to targeting of cancer hallmarks that were not affected by the single drugs. Our findings, obtained with a highly clinically relevant prostate cancer model, suggest, for the first time, that docetaxel-based therapy of advanced human prostate cancer may be improved by combining docetaxel with Aneustat
Coping with newcomer “hangover”: how socialization tactics affect declining job satisfaction during early employment
New entrants to a job often experience a “hangover effect,” whereby their job satisfaction declines as they become familiar with the job. Socialization scholars thus have sought to identify ways to forestall or ameliorate such declines. Recently, Boswell, Shipp, Payne, and Culbertson (2009) found that the extent of socialization can exacerbate the hangover effect. Following up this provocative finding, this study investigated whether socialization tactics worsen or dampen the hangover effect and by so doing, affect newcomer attrition. We monitored how newcomers' job satisfaction changed over time by surveying them on four occasions during the first six months of employment. We observed that socialization tactics (especially context and social tactics) increase the rate of declining job satisfaction during early employment. Yet all three tactics decrease this descent rate when enacted at high levels. Moreover, the present research established that declining job satisfaction translates into a trajectory of increasing turnover intentions and thus higher quits. Further, we found that extremely high social tactics can actually suppress the hangover effect and thereby reduce newcomer attrition. Our dynamic research offered a more nuanced understanding of how socialization tactics influence the hangover effect and newcomer attrition
New Luttinger liquid physics from photoemission on LiMoO
Temperature dependent high resolution photoemission spectra of quasi-1
dimensional LiMoO evince a strong renormalization of its
Luttinger liquid density-of-states anomalous exponent. We trace this new effect
to interacting charge neutral critical modes that emerge naturally from the
two-band nature of the material. LiMoO is shown thereby to
be a paradigm material that is capable of revealing new Luttinger physics.Comment: 4 pages, 3 figures. Accepted for publication by Phys. Rev. Let
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LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development.
Developmental progression depends on temporally defined changes in gene expression mediated by transient exposure of lineage intermediates to signals in the progenitor niche. To determine whether cell-intrinsic epigenetic mechanisms contribute to signal-induced transcriptional responses, here we manipulate the signalling environment and activity of the histone demethylase LSD1 during differentiation of hESC-gut tube intermediates into pancreatic endocrine cells. We identify a transient requirement for LSD1 in endocrine cell differentiation spanning a short time-window early in pancreas development, a phenotype we reproduced in mice. Examination of enhancer and transcriptome landscapes revealed that LSD1 silences transiently active retinoic acid (RA)-induced enhancers and their target genes. Furthermore, prolonged RA exposure phenocopies LSD1 inhibition, suggesting that LSD1 regulates endocrine cell differentiation by limiting the duration of RA signalling. Our findings identify LSD1-mediated enhancer silencing as a cell-intrinsic epigenetic feedback mechanism by which the duration of the transcriptional response to a developmental signal is limited
Spatially Resolved Far-Ultraviolet Spectroscopy of the Nuclear Region of NGC 1068
We carry out high-resolution FUSE spectroscopy of the nuclear region of NGC
1068. The first set of spectra was obtained with a 30" square aperture that
collects all emission from the narrow-line region. The data reveal a strong
broad OVI component of FWHM ~3500 kms-1 and two narrow OVI 1031/1037 components
of ~350 kms-1. The CIII 977 and NIII 991 emission lines in this spectrum can be
fitted with a narrow component of FWHM ~1000 kms-1 and a broad one of ~2500
kms-1. Another set of seven spatially resolved spectra were made using a long
slit of 1.25" X 20", at steps of ~1" along the axis of the emission-line cone.
We find that (1) Major emission lines in the FUSE wavelength range consist of a
broad and a narrow component; (2) There is a gradient in the velocity field for
the narrow OVI component of ~200 kms-1 from ~2" southwest of the nucleus to ~4"
northeast. A similar pattern is also observed with the broad OVI component,
with a gradient of ~3000 kms-1. These are consistent with the HST/STIS findings
and suggest a biconical structure in which the velocity field is mainly radial
outflow; (3) A major portion of the CIII and NIII line flux is produced in the
compact core. They are therefore not effective temperature diagnostics for the
conical region; and (4) The best-fitted UV continuum suggests virtually no
reddening, and the HeII 1085/1640 ratio suggests a consistently low extinction
factor across the cone.Comment: To appear in the Astrophysical Journal. 37 pages with 12 figure
Exact Numerical Solution of the BCS Pairing Problem
We propose a new simulation computational method to solve the reduced BCS
Hamiltonian based on spin analogy and submatrix diagonalization. Then we
further apply this method to solve superconducting energy gap and the results
are well consistent with those obtained by Bogoliubov transformation method.
The exponential problem of 2^{N}-dimension matrix is reduced to the polynomial
problem of N-dimension matrix. It is essential to validate this method on a
real quantumComment: 7 pages, 3 figure
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