Pathogenesis of feline enteric coronavirus infection.

Fifty-one specific pathogen-free (SPF) cats 10 weeks to 13 years of age were infected with a cat-to-cat fecal-oral passed strain of feline enteric coronavirus (FECV). Clinical signs ranged from unapparent to a mild and self-limiting diarrhea. Twenty-nine of these cats were FECV naïve before infection and followed sequentially for fecal virus shedding and antibody responses over a period of 8-48 months. Fecal shedding, as determined by real-time polymerase chain reaction (RT-PCR) from rectal swabs, appeared within a week and was significantly higher in kittens than older cats. FECV shedding remained at high levels for 2-10 months before eventually evolving into one of three excretion patterns. Eleven cats shed the virus persistently at varying levels over an observation period of 9-24 months. Eleven cats appeared to have periods of virus shedding interlaced with periods of non-shedding (intermittent or recurrent shedders), and seven cats ceased shedding after 5-19 months (average 12 months). There was no change in the patterns of virus shedding among cats that were excreting FECV at the time of a secondary challenge exposure. Four cats, which had ceased shedding, re-manifested a primary type infection when secondarily infected. Cats with higher feline coronavirus (FCoV) antibody titers were significantly more likely to shed virus, while cats with lower titers were significantly less likely to be shedding. Twenty-two kittens born to experimentally infected project queens began shedding virus spontaneously, but never before 9-10 weeks of age. Natural kittenhood infections appeared to be low grade and abortive. However, a characteristic primary type infection occurred following experimental infection with FECV at 12-15 weeks of age. Pregnancy, parturition and lactation had no influence on fecal shedding by queens. Methylprednisolone acetate treatment did not induce non-shedders to shed and shedders to increase shedding

The Ursinus Weekly, November 9, 1925

Ursinus campaign opens with liberal response • Student campaign a big success • Varsity defeated by Swarthmore • Campaign to help Ursinus enlarge in church work • Old rivals to battle at Lancaster on Saturday • Hockey team ties Temple and wins from Beaver • 1927 Ruby elections held • Rev. Nickel\u27s death mourned by many • Dr. Allen speaks at YM meeting • Brotherhood of St. Paulhttps://digitalcommons.ursinus.edu/weekly/2261/thumbnail.jp

The Ursinus Weekly, October 5, 1925

Montgomery & Bucks County press league in annual meeting • Minna Just Keller to give organ recital • Elaborate program is announced for entertainment • Tennis tournaments now under way • Bears late rally bumps Schuylkill by 13-6 score • Senior play Arms and the Man proves big success at Lansdale • Lone touchdown gives Perkiomen 6-0 win over junior varsity • Junior class elects Robert Henkels president • College orchestra formed at recent meeting • New cheer leaders elected at meeting • Student council holds first dance Saturday night • Jing Johnson, \u2716 to coach Lehigh hurlers • Freshmen class elects officers • National student forum journalism conference • Rhodes scholarships recently announcedhttps://digitalcommons.ursinus.edu/weekly/2256/thumbnail.jp

The Ursinus Weekly, January 25, 1926

Ursinus campaign is lengthened in Norristown • 1927 Ruby staff selected to use historical theme • Men\u27s debating schedule is announced by manager • Red and black five to oppose Penn Saturday • Joint YM & YWCA secures Rev. McKeehan to lead week of prayer • Founders\u27 Day exercises to be observed February 11 with Charles E. Buery speaker • Dr. William Ford delivers impressive address to students in Bomberger • Arrangements are made for large valentine fete • Men\u27s Glee Club sings at banquet in Valley Forge hotel • Elwood Peters \u2726 is forced home because of illness • Girls\u27 basketball team loses to Beaver College in opener • Nelsen Schlegel \u2723 writes letter from holy land • Opportunities are offered for U.S. students abroad • Men\u27s student council grant frosh privileges • Title is announced for popular essay contest • New physical director takes charge of girlshttps://digitalcommons.ursinus.edu/weekly/2269/thumbnail.jp

The Ursinus Weekly, September 28, 1925

Organization of alumni and friends respond liberally to campaign • Y.M. & Y.W.C.A. assemble in first joint meeting • Bears venture from their lair to be defeated by strong Penn eleven • How opponents of Ursinus fared in opening contests • A different annual is the motto adopted by Ruby • Seniors to present play at Lansdale Friday night • Men\u27s Debating Club holds opening meeting of year • Student council dance to be held Saturday night • Albert Lackman elected head of sophomore class • Ursinus soph wins laurels in tennis • Girls\u27 swimming class • Classical group elects • Civil service commission announces examinations • Lehigh University opens with large freshmen classhttps://digitalcommons.ursinus.edu/weekly/2255/thumbnail.jp

The Ursinus Weekly, March 15, 1926

Debaters take two from Temple University • New student list growing • Court season comes to successful close • Rev. Oliver Russell delivers two valuable addresses • Baseball candidates await fit weather • 1926 different Ruby arrives on campus • Women\u27s Glee Club renders first concert • Glee Club pleases Center Point audience • Varsity five nosed out by Temple University • Ursinus lassies lose to strong Temple sextet • Philadelphia Alumni Association to hold banquet • Dr. J. W. Clawson elected vice president of Pennsylvania conference • Mr. Rosenberger resigns • Mercersburg honors Stanley Omwake • Zwing play cast making rapid progress • Sophs outclass frosh in annual contest • Junior varsity loses by one point to Penn J.V.\u27shttps://digitalcommons.ursinus.edu/weekly/2275/thumbnail.jp

The Ursinus Weekly, January 11, 1926

Campaign shows progress during recent holidays • Seniors to present Arms and the Man at Allentown • Rev. Niven gives reading of noted English tragedy • Stanley Moyer is elected captain of \u2726 grid team • Basketball season opens with three large victories • Faculty grants leave of absence to Miss McGowan to travel around world • Rev. Harold Kerschner, \u2716 delivers strong address to students in chapel • 1926 football schedule is announced by graduate manager • College executive and financial committees meet on Saturday • Schaff to present Beau Brummel on February 26 • Men\u27s forensic season to open at Elizabethtown • Women\u27s Debating Club meets • John Moore \u2727 speaks to men at YM meeting • Christmas YW meeting held at Superhouse • Men\u27s Debating Club meets • Debaters are arranged • Comments on the grizzly calendar • J.V. basketball team loses to Philadelphia YMCAhttps://digitalcommons.ursinus.edu/weekly/2267/thumbnail.jp

The Ursinus Weekly, September 21, 1925

Excellent program at college opening • Pep overflows at first of booster meetings • Ursinus recipient of new gateway • Alumni Association holds business meeting • Great progress in endowment drive • New faces again noticed among faculty members • Y.M.-Y.W. reception held in new surroundings • Chester Brachman elected senior class president • Six ways to get to the Penn game • Club will soon begin forensic activities • Freshmen pull one over on last year\u27s frosh • Statistics of the bears who will invade Franklin Field • Glenwood Hall girls are pleased with new location • Women\u27s Debating Club opens with social • Heidelberg Reformed Church to be relocatedhttps://digitalcommons.ursinus.edu/weekly/2254/thumbnail.jp

The Ursinus Weekly, May 4, 1925

National music week will be observed here • Women\u27s Debating Club holds regular meeting • New athletic council organized by directors • Indiana wins national oratorical contest • Albright nine defeated varsity in close game • Dining hall to be scene of Biology Club banquet • May Day preparations promise gala affair • Junior varsity defeats Hill School in loose game • Last informal musical recital given at Maples • Ursinus host to INA conference • Zimmerman severs connections as athletic director at Ursinus • Professor Sawhill addresses YMCA meeting • H. C. Baldwin gives talkhttps://digitalcommons.ursinus.edu/weekly/2316/thumbnail.jp

The Ursinus Weekly, April 27, 1925

Interscholastic teams enter final contest • Music week to open with recital by Miss Mosser • Arms and the Man to be presented by juniors • Varsity debaters enjoy delightful banquet • Coach Zimmerman resigns as director of athletics • Ursinus nine drops close game to Lebanon Valley • Ursinus tennis team loses match to Moravian • Men\u27s Glee Club renders concert at Phoenixville • Professor Witmer sends letter of thanks to students • Miss Threapleton speaks to Conshohocken students • Miss Gest\u27s students give music recital at Maples • Edmund Welker chosen president of YMCA • Japan college offers positions for women • Mr. Stoneback addresses the YMCA meeting • Dean White addresses YW • Editorial comment: Christian organizations • Brotherhood of St. Paul • Brenner writes articlehttps://digitalcommons.ursinus.edu/weekly/2315/thumbnail.jp