Electron self-trapping on a nano-circle

We study the self-trapping of quasiparticles (electrons, holes, excitons, etc) in a molecular chain with the structure of a ring, taking into account the electron-phonon interaction and the radial and tangential deformations of the chain. A discrete system of equations is obtained and solved numerically. The analytical solutions for the wave function of a quasiparticle and for the molecule displacements that determine the distortion of the ring, are also obtained and solved in the continuum approximation. The numerical solutions of the system of discrete nonlinear equations reveals several regimes of quasiparticle localisation in the chain which depend on the values of the parameters of the system. It is shown that the transversal deformation of the chain favours the formation of a soliton.Comment: 43 pages 9 figure

Molecular determinants of invasion in endometrial cancer

Endometrial carcinoma is the most common gynaecological malignancy in the western world and the most frequent among infiltrating tumours of the female genital tract. Despite the characterisation of molecular events associated with the development of endometrial carcinoma, those associated with the early steps of infiltration and invasion in endometrial cancer are less known. Deep myometrial invasion correlates with more undifferentiated tumours, lymph-vascular invasion, node affectation and decreased global survival. In this review we present an overview of the molecular pathology of myometrial infiltration that defines the initial steps of invasion in endometrial cancer. Down-regulation of E-cadherin as a main player of epithelial to mesenchymal transition, as well as modifications on other molecules involved in cell-cell contacts, render cells with a migratory phenotype. In addition, altered signalling pathways and transcription factors associate with myometrial invasion, histologic grade and metastasis.Fil: Abal, M.. Hospital Universitari Vall d; EspañaFil: Llaurado, M.. Hospital Universitari Vall d; EspañaFil: Dolla, A.. Hospital Universitari Vall d; EspañaFil: Monge, M.. Hospital Universitari Vall d; EspañaFil: Colas, E.. Hospital Universitari Vall d; EspañaFil: Gonzalez, M.. Hospital Universitari Vall d; EspañaFil: Rigau, M.. Hospital Universitari Vall d; EspañaFil: Allazzouzi, H.. Hospital Universitari Vall d; EspañaFil: Demajo, S.. Hospital Universitari Vall d; EspañaFil: Castellví, J.. Hospital Universitari Vall d; España. Universitat Autònoma de Barcelona; EspañaFil: Garcia, A.. Hospital Universitari Vall d; España. Universitat Autònoma de Barcelona; EspañaFil: Ramon y Cajal, S.. Hospital Universitari Vall d; España. Universitat Autònoma de Barcelona; EspañaFil: Xercavins, J.. Hospital Universitari Vall d; España. Universitat Autònoma de Barcelona; EspañaFil: Vazquez, Monica Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Alameda, F.. Universitat Autònoma de Barcelona; España. Hospital del Mar; EspañaFil: Gil Moreno, A.. Hospital Universitari Vall d; España. Universitat Autònoma de Barcelona; EspañaFil: Reventos, J.. Universitat Autònoma de Barcelona; España. Hospital Universitari Vall d; Españ