Prescribing patterns of gastrointestinal drugs in private clinics in Benghazi-Libya

Background: Prescription analysis can pinpoint areas of improvement in encounters issued by prescribing physicians. The present study was carried out to analyze prescribing trends for outpatients among consultants in the city of Benghazi-Libya.Methods: A total of 4000 prescriptions were collected from private pharmacies around the city of Benghazi, Libya. Indicators addressed included the patient's name, age, sex, and address, and the physician's name, address, and signature. The percentage of prescriptions lacking this information was calculated. Drugs prescribed by dosage, duration of treatment were also considered. The study focused on the commonly prescribed classes of gastrointestinal drugs and the most frequently prescribed drug of each common class. No attempt was made to evaluate the incidence of various gastrointestinal disorders. Results are expressed as frequency and percentage of prescribed medicines.Results: Information present in prescriptions and pertaining to the patient were name (2972, 74.3%), age (468, 11.7%), date of visit (107, 2.7%) while those for prescriber were name (1902, 47.6%) and signature (3612, 90.3%). None of the prescriptions contained sex of patient, his/her address, or registration number of the prescriber. All prescribed drugs were in brand names. Polypharmacy was not evident as all prescriptions contained 1-2 drugs.The number of prescriptions with a gastrointestinal drug(s) counted to 421 (10.5%) out of the total 4000 prescriptions. The most commonly prescribed classes of gastrointestinal drugs include in order, anti-hyperacidity, anti-emetics, anti-spasmodic, laxatives and anti-diarrheal with the most frequently prescribed drug of each therapeutic class being omeprazole (67, 48.9%), metoclopramide (57, 57%), hyoscine-N-butyl bromide (42, 55.3%), bisacodyl (44, 59.5%) and loperamide (30, 88.3%) respectively.Conclusions: The results of the present study indicate the need to improve prescribing among physicians, a task that can be achieved through inclusion of related topics such as prescription writing and rational drug use in undergraduate curricula and continuing medical educational programs

Antioxidant Activity of Quercetin 3-O-alpha-L-Arabinopyranoside Isolated from Hibiscus Vitifolius (Linn.) in Mercury Chloride Induced Toxicity

The fresh flowers of Hibiscus vitifolius Linn. were screened to determine antioxident activity. A methanol extract of flower was prepared and partitioned sequentially with petrol, ether and ethyl acetate. The active compounds were identified by UV, 1H NMR (Proton Nuclear Magnetic Resonance) and 13C NMR (Carbon-13 Nuclear Magnetic Resonance) as quercetin and quercetin 3-0-arabinopyranoside. The antioxident activity was also studied in mercury chloride (HgCl2) toxicity through biochemical parameters such as SOD, CAT, GSH, GPX, AST, LPO, vitamin C, vitamin E and urea. Quercetin 3-0-arabinopyranoside treated rats showed decrease in lipid peroxidation. Statistically significant increased in enzymes compared to HgCl2 induced group was observed. Which indicates that quercetin 3-0-arabinopyranoside isolated from the flowers of Hibiscus vitifolius act as a potent antioxidant

Prescribing patterns of gastrointestinal drugs in private clinics in Benghazi-Libya

Background: Prescription analysis can pinpoint areas of improvement in encounters issued by prescribing physicians. The present study was carried out to analyze prescribing trends for outpatients among consultants in the city of Benghazi-Libya.Methods: A total of 4000 prescriptions were collected from private pharmacies around the city of Benghazi, Libya. Indicators addressed included the patient's name, age, sex, and address, and the physician's name, address, and signature. The percentage of prescriptions lacking this information was calculated. Drugs prescribed by dosage, duration of treatment were also considered. The study focused on the commonly prescribed classes of gastrointestinal drugs and the most frequently prescribed drug of each common class. No attempt was made to evaluate the incidence of various gastrointestinal disorders. Results are expressed as frequency and percentage of prescribed medicines.Results: Information present in prescriptions and pertaining to the patient were name (2972, 74.3%), age (468, 11.7%), date of visit (107, 2.7%) while those for prescriber were name (1902, 47.6%) and signature (3612, 90.3%). None of the prescriptions contained sex of patient, his/her address, or registration number of the prescriber. All prescribed drugs were in brand names. Polypharmacy was not evident as all prescriptions contained 1-2 drugs.The number of prescriptions with a gastrointestinal drug(s) counted to 421 (10.5%) out of the total 4000 prescriptions. The most commonly prescribed classes of gastrointestinal drugs include in order, anti-hyperacidity, anti-emetics, anti-spasmodic, laxatives and anti-diarrheal with the most frequently prescribed drug of each therapeutic class being omeprazole (67, 48.9%), metoclopramide (57, 57%), hyoscine-N-butyl bromide (42, 55.3%), bisacodyl (44, 59.5%) and loperamide (30, 88.3%) respectively.Conclusions: The results of the present study indicate the need to improve prescribing among physicians, a task that can be achieved through inclusion of related topics such as prescription writing and rational drug use in undergraduate curricula and continuing medical educational programs