15 research outputs found
Surgery and radioembolization of liver tumors
Surgical resection is considered the curative treatment par excellence for patients with primary or
metastatic liver tumors. However, less than 40% of them are candidates for surgery, either due to nonmodifiable factors (comorbidities, age, liver dysfunction. . .), or to the invasion or proximity of the tumor
to the main vascular requirements, the lack of a future liver remnant (FLR) adequate to maintain postoperative liver function, or criteria oftumor size and number. In these lastfactors, hepatic radioembolization
has been shown to play a role as a presurgical tool, either by hypertrophy of the FLR or by reducing tumor
size that manages to reduce tumor staging (term known as downstaging ¨ ¨
). To these is added a third factor,
which is its ability to apply the test oftime, which makes it possible to identify those patients who present
progression of the disease in a short period of time (both locally and at distance), avoiding a unnecessary
surgery. This paper aims to review RE as a tool to facilitate liver surgery, both through the experience of
our center and the available scientific evidence.La resección quirúrgica se considera eltratamiento curativo por excelencia para los pacientes con tumores
hepáticos primarios o metastásicos. Sin embargo, menos del 40% de ellos son candidatos a cirugía, ya
sea por factores no modificables (comorbilidades, edad, disfunción hepática. . .), como por la invasión o
proximidad del tumor a los principales pedículos vasculares, la falta de un futuro remanente hepático
(FRH) adecuado para mantener una función hepática postoperatoria, o criterios de tamano˜ y numero
tumoral. En estos últimos factores, la radioembolización hepática ha mostrado tener un papel como
herramienta prequirúrgica, ya sea mediante la hipertrofia del FRH o mediante la reducción del tamano˜
tumoral que consigue disminuir la estadificación tumoral (término conocido como “downstaging”). A
estos se suma un tercer factor, que es su capacidad de aplicar el test del tiempo, que permite identificar
aquellos pacientes que presenten en un plazo corto de tiempo progresión de la enfermedad (tanto a
nivel local como a distancia), evitándoles una cirugía innecesaria. En este trabajo se pretende hacer una
revisión de la RE como herramienta facilitadora de la cirugía hepática, tanto a través de la experiencia de
nuestro centro como de la evidencia científica disponible
Association of laparoscopic surgery with improved perioperative and survival outcomes in patients with resectable intrahepatic cholangiocarcinoma: A systematic seview and meta-analysis from propensity-score matched studies
Background: Recent studies have associated laparoscopic surgery with better overall survival (OS) in patients with hepatocellular carcinoma (HCC) and colorectal liver metastasis (CRLM). The potential benefits of laparoscopic liver resection (LLR) over open liver resection (OLR) have not been demonstrated in patients with intrahepatic cholangiocarcinoma (iCC).
Methods: A systematic review of the PubMed, EMBASE, and Web of Science databases was performed to search studies comparing OS and perioperative outcome for patients with resectable iCC. Propensity-score matched (PSM) studies published from database inception to May 1, 2022 were eligible. A frequentist, patient-level, one-stage meta-analysis was performed to analyze the differences in OS between LLR and OLR. Second, intraoperative, postoperative, and oncological outcomes were compared between the two approaches by using a random-effects DerSimonian-Laird model.
Results: Six PSM studies involving data from 1.042 patients (530 OLR vs. 512 LLR) were included. LLR in patients with resectable iCC was found to significantly decrease the hazard of death (stratified hazard ratio [HR]: 0.795 [95% confidence interval [CI]: 0.638-0.992]) compared with OLR. Moreover, LLR appears to be significantly associated with a decrease in intraoperative bleeding (- 161.47 ml [95% CI - 237.26 to - 85.69 ml]) and transfusion (OR = 0.41 [95% CI 0.26-0.69]), as well as with a shorter hospital stay (- 3.16 days [95% CI - 4.98 to - 1.34]) and a lower rate of major (Clavien-Dindo ≥III) complications (OR = 0.60 [95% CI 0.39-0.93]).
Conclusions: This large meta-analysis of PSM studies shows that LLR in patients with resectable iCC is associated with improved perioperative outcomes and, being conservative, yields similar OS outcomes compared with OLR
Surgery and radioembolization of liver tumors
Surgical resection is considered the curative treatment par excellence for patients with primary or
metastatic liver tumors. However, less than 40% of them are candidates for surgery, either due to nonmodifiable factors (comorbidities, age, liver dysfunction. . .), or to the invasion or proximity of the tumor
to the main vascular requirements, the lack of a future liver remnant (FLR) adequate to maintain postoperative liver function, or criteria oftumor size and number. In these lastfactors, hepatic radioembolization
has been shown to play a role as a presurgical tool, either by hypertrophy of the FLR or by reducing tumor
size that manages to reduce tumor staging (term known as downstaging ¨ ¨
). To these is added a third factor,
which is its ability to apply the test oftime, which makes it possible to identify those patients who present
progression of the disease in a short period of time (both locally and at distance), avoiding a unnecessary
surgery. This paper aims to review RE as a tool to facilitate liver surgery, both through the experience of
our center and the available scientific evidence.La resección quirúrgica se considera eltratamiento curativo por excelencia para los pacientes con tumores
hepáticos primarios o metastásicos. Sin embargo, menos del 40% de ellos son candidatos a cirugía, ya
sea por factores no modificables (comorbilidades, edad, disfunción hepática. . .), como por la invasión o
proximidad del tumor a los principales pedículos vasculares, la falta de un futuro remanente hepático
(FRH) adecuado para mantener una función hepática postoperatoria, o criterios de tamano˜ y numero
tumoral. En estos últimos factores, la radioembolización hepática ha mostrado tener un papel como
herramienta prequirúrgica, ya sea mediante la hipertrofia del FRH o mediante la reducción del tamano˜
tumoral que consigue disminuir la estadificación tumoral (término conocido como “downstaging”). A
estos se suma un tercer factor, que es su capacidad de aplicar el test del tiempo, que permite identificar
aquellos pacientes que presenten en un plazo corto de tiempo progresión de la enfermedad (tanto a
nivel local como a distancia), evitándoles una cirugía innecesaria. En este trabajo se pretende hacer una
revisión de la RE como herramienta facilitadora de la cirugía hepática, tanto a través de la experiencia de
nuestro centro como de la evidencia científica disponible
Analysis of Factors Influencing Accuracy of Volume Flow Measurement in Dialysis Access Fistulas Based on Duplex Ultrasound Simulation
Association of laparoscopic surgery with improved perioperative and survival outcomes in patients with resectable intrahepatic cholangiocarcinoma: A systematic seview and meta-analysis from propensity-score matched studies
Background: Recent studies have associated laparoscopic surgery with better overall survival (OS) in patients with hepatocellular carcinoma (HCC) and colorectal liver metastasis (CRLM). The potential benefits of laparoscopic liver resection (LLR) over open liver resection (OLR) have not been demonstrated in patients with intrahepatic cholangiocarcinoma (iCC).
Methods: A systematic review of the PubMed, EMBASE, and Web of Science databases was performed to search studies comparing OS and perioperative outcome for patients with resectable iCC. Propensity-score matched (PSM) studies published from database inception to May 1, 2022 were eligible. A frequentist, patient-level, one-stage meta-analysis was performed to analyze the differences in OS between LLR and OLR. Second, intraoperative, postoperative, and oncological outcomes were compared between the two approaches by using a random-effects DerSimonian-Laird model.
Results: Six PSM studies involving data from 1.042 patients (530 OLR vs. 512 LLR) were included. LLR in patients with resectable iCC was found to significantly decrease the hazard of death (stratified hazard ratio [HR]: 0.795 [95% confidence interval [CI]: 0.638-0.992]) compared with OLR. Moreover, LLR appears to be significantly associated with a decrease in intraoperative bleeding (- 161.47 ml [95% CI - 237.26 to - 85.69 ml]) and transfusion (OR = 0.41 [95% CI 0.26-0.69]), as well as with a shorter hospital stay (- 3.16 days [95% CI - 4.98 to - 1.34]) and a lower rate of major (Clavien-Dindo ≥III) complications (OR = 0.60 [95% CI 0.39-0.93]).
Conclusions: This large meta-analysis of PSM studies shows that LLR in patients with resectable iCC is associated with improved perioperative outcomes and, being conservative, yields similar OS outcomes compared with OLR
Survival and safety after neoadjuvant chemotherapy or upfront surgery for locally advanced colon cancer: meta-analysis
Background: Neoadjuvant chemotherapy is increasingly used to treat locally advanced (T3-4 Nx-2 M0) colon cancer due to its potential advantages over the standard approach of upfront surgery. The primary objective of this systematic review and meta-analysis was to analyse data from comparative studies to assess the impact of neoadjuvant chemotherapy on oncological outcomes.
Methods: A systematic review was conducted by searching the MEDLINE and Scopus databases. The search encompassed RCTs, propensity score-matched studies, and controlled prospective studies published up to 1 April 2023. As a primary objective, overall survival and disease-free survival were compared. As a secondary objective, perioperative morbidity, mortality, and complete resection were compared using the DerSimonian and Laird models.
Results: A total of seven studies comprising a total of 2120 patients were included. Neoadjuvant chemotherapy was associated with a reduction in the hazard of recurrence (HR 0.73, 95% c.i. 0.59 to 0.90; P = 0.003) and death (HR 0.67, 95% c.i. 0.54 to 0.83; P < 0.001) compared with upfront surgery. Additionally, neoadjuvant chemotherapy was significantly associated with higher 5-year overall survival (79.9% versus 72.6%; P < 0.001) and disease-free survival (73.1% versus 64.5%; P = 0.028) rates. No significant differences were observed in perioperative mortality (OR 0.97, 95% c.i. 0.28 to 3.33), overall complications (OR 0.95, 95% c.i. 0.77 to 1.16), or anastomotic leakage/intra-abdominal abscess (OR 0.88, 95% c.i. 0.60 to 1.29). However, neoadjuvant chemotherapy was associated with a lower risk of incomplete resection (OR 0.70, 95% c.i. 0.49 to 0.99).
Conclusion: Neoadjuvant chemotherapy is associated with a reduced hazard of recurrence and death, as well as improved overall survival and disease-free survival rates, compared with upfront surgery in patients with locally advanced colon cancer
Minimally invasive liver surgery for hepatocellular carcinoma in patients with portal hypertension
For patients with early stage hepatocellular carcinoma (HCC),
liver resection is a mainstay of curative treatment. Patients with
a solitary tumour, Child–Pugh A cirrhosis and serum bilirubin of
1 mg/dl are considered ideal candidates for liver resection1,2
.
For patients with portal hypertension, current guidelines
recommend careful consideration of liver resection based on the
hierarchical interaction of portal hypertension, liver function
and resection extent1,3
. Open liver resection has been used in
the majority of published studies on liver resection and portal
hypertension. Although there is limited published experience of
minimally invasive liver resection (MILR), using MILR in these
patients appears to be associated with favourable outcomes4
.
Particularly in patients with Child–Pugh A cirrhosis, but also in
patients with more advanced cirrhosis5
, MILR offers significant
advantages in the surgical treatment of HCC including reduced
intraoperative bleeding, fewer complications and minimized
surgical aggression, which improves recovery6,7
. If these benefits
are also found in patients with portal hypertension, MILR may
represent a step forward in the surgical treatment of patients
with HCC and portal hypertension.
This systematic review and meta-analysis aimed to summarize
the intraoperative, postoperative and survival outcomes of MILR
in patients with HCC and portal hypertension
Exploring the Dynamics of Delegation Over Time: Insights from Italian Anti‐Corruption Agencies (2003–2016)
Pure laparoscopic major liver resection after yttrium90 radioembolization: a case-matched series analysis of feasibility and outcomes
Background: Liver surgery after radioembolization (RE) entails highly demanding and challenging procedures due to the frequent combination of large tumors, severe RE-related adhesions, and the necessity of conducting major hepatectomies. Laparoscopic liver resection (LLR) and its associated advantages could provide benefits, as yet unreported, to these patients. The current study evaluated feasibility, morbidity, mortality, and survival outcomes for major laparoscopic liver resection after radioembolization.
Material and methods: In this retrospective, single-center study patients diagnosed with hepatocellular carcinoma, intrahepatic cholangiocarcinoma or metastases from colorectal cancer undergoing major laparoscopic hepatectomy after RE were identified from institutional databases. They were matched (1:2) on several pre-operative characteristics to a group of patients that underwent major LLR for the same malignancies during the same period but without previous RE.
Results: From March 2011 to November 2020, 9 patients underwent a major LLR after RE. No differences were observed in intraoperative blood loss (50 vs. 150 ml; p: 0.621), operative time (478 vs. 407 min; p: 0.135) or pedicle clamping time (90.5 vs 74 min; p: 0.133) between the post-RE LLR and the matched group. Similarly, no differences were observed on hospital stay (median 3 vs. 4 days; p = 0.300), Clavien-Dindo ≥ III complications (2 vs. 1 cases; p: 0.250), specific liver morbidity (1 vs. 1 case p: 1.000), or 90 day mortality (0 vs. 0; p: 1.000).
Conclusion: The laparoscopic approach for post radioembolization patients may be a feasible and safe procedure with excellent surgical and oncological outcomes and meets the current standards for laparoscopic liver resections. Further studies with larger series are needed to confirm the results herein presented