109 research outputs found
Factors Dictating Carbene Formation at (PNP)Ir
The mechanistic subtleties involved with the interaction of an amido/bis(phosphine)-supported (PNP)Ir fragment with a series of linear and cyclic ethers have been investigated using density functional theory. Our analysis has revealed the factors dictating reaction direction toward either an iridium-supported carbene or a vinyl ether adduct. The (PNP)Ir structure will allow carbene formation only from accessible carbons α to the ethereal oxygen, such that d electron back-donation from the metal to the carbene ligand is possible. Should these conditions be unavailable, the main competing pathway to form vinyl ether can occur, but only if the (PNP)Ir framework does not sterically interfere with the reacting ether. In situations where steric hindrance prevents unimpeded access to both pathways, the reaction may progress to the initial CâH activation but no further. Our mechanistic analysis is density functional independent and whenever possible confirmed experimentally by trapping intermediate species experimentally. We have also highlighted an interesting systematic error present in the DFT analysis of reactions where steric environment alters considerably within a reaction
Chiral BrĂžnsted acid catalyzed enantioselective dehydrative Nazarov-type electrocyclization of aryl and 2-Thienyl vinyl alcohols
An efficient chiral BrĂžnsted acid-catalyzed enantioselective dehydrative Nazarov-type electrocyclization (DNE) of electron-rich aryl- and 2-thienyl-ÎČ-amino-2-en-1-ols is described. The 4Ï conrotatory electrocyclization reaction affords access to a wide variety of the corresponding 1H-indenes and 4H-cyclopenta[b]thiophenes in excellent yields of up to 99% and enantiomeric excess (ee) values of up to 99%. Experimental and computational studies based on a proposed intimate contact ion-pair species that is further assisted by hydrogen bonding between the amino group of the substrate cation and chiral catalyst anion provide insight into the observed product enantioselectivities
Triarylborane catalysed n-alkylation of amines with aryl esters
The ability of halogenated triarylboranes to accept a lone pair of electrons from donor substrates renders them excellent Lewis acids which can be exploited as a powerful tool in organic synthesis. Tris(pentafluorophenyl)borane has successfully demonstrated its ability to act as a metal-free catalyst for an ever-increasing range of organic transformations. Herein we report the N-alkylation reactions of a wide variety of amine substrates including diarylamines, N-methylphenyl amines, and carbazoles with aryl esters using catalytic amounts of B(C6F5)3. This mild reaction protocol gives access to N-alkylated products (35 examples) in good to excellent yields (up to 95%). The construction of a CâN bond at the propargylic position has also been demonstrated to yield synthetically useful propargyl amines. On the other hand, unsubstituted 1H-indoles and 1H-pyrroles at the C3/C2 positions afforded exclusively CâC coupled products. Extensive DFT studies have been employed to understand the mechanism for this transformation
Borane-ctalyzed stereoselective CâH insertion, cyclopropanation, and ring-opening reactions
Lewis acidic boranes have been shown to be effective metal-free catalysts for highly selective reactions of donor-acceptor diazo compounds to a range of substrates. The reactions of α-aryl α-diazoesters with nitrogen heterocycles indole or pyrrole selectively generate C3 and C2 CâH insertion products, respectively, in good to excellent yields even when using unprotected indoles. Alternatively, benzofuran, indene, and alkene substrates give exclusively cyclopropanated products with α-aryl α-diazoesters, whereas the reactions with furans lead to ring-opening. Comprehensive theoretical calculations have been used to explain the differing reactivities and high selectivities of these reactions. Overall, this work demonstrates the selective metal-free catalytic reactions of α-aryl α-diazoesters with (hetero)cycles and alkenes. This simple, mild reaction protocol represents an alternative to the commonly used precious metal systems and may provide future applications in the generation of biologically active compounds
Theoretical rationalisation for the mechanism of N-heterocyclic carbene-halide reductive elimination at CuIII, AgIII and AuIII
Reductive elimination of imidazolium salts from CuIII is extremely sensitive to the anionic ligand (X or Y) type on Cu (e.g. ÎG⥠ranges from 4.7 kcal mol-1 to 31.8 kcal mol-1, from chloride to benzyl). Weakly Ï-donating ligands dramatically accelerate reductive elimination. Comparison with Ag/Au shows that the HOMO energy, strength of M-NHC and M-Y bonds and inherent stability of MIII with respect to MI are critical to governing reaction feasibility
Proton supplier role of binuclear gold complexes in promoting hydrofunctionalisation of nonactivated alkenes
Density functional theory (DFT) was used to investigate PR 3 AuOTf-catalyzed hydrofunctionalisation of nonactivated alkenes using acetic acid and phenol where OTf = triflate (CF 3 SO 3- ). The gold(i) complex itself is found to be unlikely to operate as the Ï-activator due to its relatively low electrophilicity. Instead, the concurrent coordination of two gold(i) complexes to a nucleophile (PhOH or AcOH) enhances the acidity of the latter\u27s proton and causes the ensuing binuclear complex to serve as a strong proton supplier for activating the alkene Ï-bonds. Alternatively, the binuclear complex is also susceptible to produce a hidden HOTf. This hidden acid is accessible for hydrofunctionalization to occur but it is not in sufficient concentration to decompose the final product
Recommended from our members
Connecting Binuclear Pd(III) and Mononuclear Pd(IV) Chemistry by PdâPd Bond Cleavage
Oxidation of binuclear Pd(II) complexes with PhICl or PhI(OAc) has previously been shown to afford binuclear Pd(III) complexes featuring a PdâPd bond. In contrast, oxidation of binuclear Pd(II) complexes with electrophilic trifluoromethylating (âCFâ) reagents has been reported to afford mononuclear Pd(IV) complexes. Herein, we report experimental and computational studies of the oxidation of a binuclear Pd(II) complex with âCFâ reagents. These studies suggest that a mononuclear Pd(IV) complex is generated by an oxidationâfragmentation sequence proceeding via fragmentation of an initially formed, formally binuclear Pd(III), intermediate. The observation that binuclear Pd(III) and mononuclear Pd(IV) complexes are accessible in the same reactions offers an opportunity for understanding the role of nuclearity in both oxidation and subsequent CâX bond-forming reactions.Chemistry and Chemical Biolog
Gold-catalyzed domino cyclization-alkynylation reactions with EBX reagents: new insights into the reaction mechanism
Gold-catalyzed domino processes constitute a useful alternative to C-H functionalization for the synthesis of functionalized (hetero)arenes. Herein, we report computational studies on the gold-catalyzed cyclization alkynylation of keto-allenes with ethynylbenziodoxole (EBX) reagents, which identified a gold(I) picolinate complex as the active catalyst, giving the first mechanistic insights into this transformation
Triarylborane-catalysed alkenylation reaction of aryl esters with diazo compounds
Herein we report a facile, mild reaction protocol to form carbonâcarbon bonds in the absence of transition metal catalysts. We demonstrate the metalâfree alkenylation reactions of aryl esters with αâdiazoesters to give highly functionalized enyne products. Catalytic amounts of tris(pentafluorophenyl)borane (10â20 mol%) are employed to afford the C=C coupled products (31 examples) in good to excellent yields (36â87%). DFT studies have been undertaken to elucidate the mechanism for this alkenylation reaction
- âŠ