Regional association plots showing genome-wide significant loci for serum TSH.

<p>In each panel (A–F), the most significant SNP is indicated (purple circle). The SNPs surrounding the most significant SNP are color-coded to reflect their LD with this SNP as in the inset (taken from pairwise r² values from the HapMap CEU database build 36/hg18). Symbols reflect genomic functional annotation, as indicated in the legend <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003266#pgen.1003266-Pruim1" target="_blank">[61]</a>. Genes and the position of exons, as well as the direction of transcription, are noted in lower boxes. In each panel the scale bar on the Y-axis changes according to the strength of the association.</p

Regional association plots showing genome-wide significant loci for serum TSH.

<p>In each panel (A–F), the most significant SNP is indicated (purple circle). In panel F, an independent signal at the associated locus is indicated with an arrow. The SNPs surrounding the most significant SNP are color-coded to reflect their LD with this SNP as in the inset (taken from pairwise r² values from the HapMap CEU database build 36/hg18). Symbols reflect genomic functional annotation, as indicated in the legend <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003266#pgen.1003266-Pruim1" target="_blank">[61]</a>. Genes and the position of exons, as well as the direction of transcription, are noted in lower boxes. In each panel the scale bar on the Y-axis changes according to the strength of the association.</p

TSH associated SNPs in extreme phenotype categories.

<p>The table shows results for the quartile-based GRS scores (top panel) and single marker (bottom panel) analyses in extreme phenotype categories, defined as TSH >4 mIU/L (UPPER) or TSH <0.4 mIU/L (LOWER). NORMAL, individuals with TSH within the normal range. OR, odds ratio; StdErr, standard error. A1, effect allele; A2 other allele. SNPs reaching the Bonferroni significance threshold are highlighted in bold.</p

Regional association plots showing genome-wide significant loci for serum TSH.

<p>In each panel (A–F), the most significant SNP is indicated (purple circle). The SNPs surrounding the most significant SNP are color-coded to reflect their LD with this SNP as in the inset (taken from pairwise r² values from the HapMap CEU database build 36/hg18). Symbols reflect genomic functional annotation, as indicated in the legend <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003266#pgen.1003266-Pruim1" target="_blank">[61]</a>. Genes and the position of exons, as well as the direction of transcription, are noted in lower boxes. In each panel the scale bar on the Y-axis changes according to the strength of the association.</p

Candidate genes at newly discovered loci for TSH and FT4 levels.

<p>The table lists genes of interest in the novel associated regions. For each associated region, the reported gene either contains the lead SNP or is in closest physical proximity with the lead SNP.</p

Newly identified TPOAb associated loci and the risk of thyroid disease in stage 1 and 2 populations.

<p>All analyses adjusted for age and gender.</p><p><i>ATXN2</i>-rs653178 is in high LD with <i>SH2B3-</i> rs3184504</p><p><i>MAGI3-</i>rs1230666 is in high LD with <i>PTPN22-</i>rs2476601</p

Population characteristics and serum TPOAb, TSH, and FT4 level measurements specifications.

<p>Population characteristics and serum TPOAb, TSH, and FT4 level measurements specifications.</p