7,775 research outputs found
Fully automated segmentation and tracking of the intima media thickness in ultrasound video sequences of the common carotid artery
AbstractâThe robust identification and measurement of the intima media thickness (IMT) has a high clinical relevance because it represents one of the most precise predictors used in the assessment of potential future cardiovascular events. To facilitate the analysis of arterial wall thickening in serial clinical investigations, in this paper we have developed a novel fully automatic algorithm for the segmentation, measurement, and tracking of the intima media complex (IMC) in B-mode ultrasound video sequences. The proposed algorithm entails a two-stage image analysis process that initially addresses the segmentation of the IMC in the first frame of the ultrasound video sequence using a model-based approach; in the second step, a novel customized tracking procedure is applied to robustly detect the IMC in the subsequent frames. For the video tracking procedure, we introduce a spatially coherent algorithm called adaptive normalized correlation that prevents the tracking process from converging to wrong arterial interfaces. This represents the main contribution of this paper and was developed to deal with inconsistencies in the appearance of the IMC over the cardiac cycle. The quantitative evaluation has been carried out on 40 ultrasound video sequences of the common carotid artery (CCA) by comparing the results returned by the developed algorithm with respect to ground truth data that has been manually annotated by clinical experts. The measured IMTmean ± standard deviation recorded by the proposed algorithm is 0.60 mm ± 0.10, with a mean coefficient of variation (CV) of 2.05%, whereas the corresponding result obtained for the manually annotated ground truth data is 0.60 mm ± 0.11 with a mean CV equal to 5.60%. The numerical results reported in this paper indicate that the proposed algorithm is able to correctly segment and track the IMC in ultrasound CCA video sequences, and we were encouraged by the stability of our technique when applied to data captured under different imaging conditions. Future clinical studies will focus on the evaluation of patients that are affected by advanced cardiovascular conditions such as focal thickening and arterial plaques
Measuring the Charged Particle Multiplicity with ALICE
The charged particle multiplicity distribution is one of the first
measurements that ALICE will be able to perform. The knowledge of this basic
property at a new energy is needed to configure Monte Carlo generators
correctly with the aim of understanding the background of other, especially
rare, processes including new physics. It allows to study the scaling behaviour
and to verify model predictions. The unfolding of the measurement is a
non-trivial task due to the finite precision and acceptance of the detector.
Solutions are based on chi2 minimization or iteratively using Bayes' theorem.
Both approaches to unfold the spectrum are presented. Furthermore, the
capabilities of the SPD fast OR trigger are shown that enable physics at very
high multiplicities.Comment: Proceedings of poster presentation at Quark Matter 2008, 20th
International Conference on Ultra-Relativistic Nucleus-Nucleus Collisions in
Jaipur, India; to be published in Indian Journal of Physics; 4 pages, 4
figure
A High-Resolution Hubble Space Telescope Study of Apparent Lyman Continuum Leakers at
We present follow-up observations of 16
candidate LyC emitters in the HS1549+1919 field. With these data, we
obtain high spatial-resolution photometric redshifts of all sub-arcsecond
components of the LyC candidates in order to eliminate foreground contamination
and identify robust candidates for leaking LyC emission. Of the 16 candidates,
we find one object with a robust LyC detection that is not due to foreground
contamination. This object (MD5) resolves into two components; we refer to the
LyC-emitting component as MD5b. MD5b has an observed 1500\AA\ to 900\AA\
flux-density ratio of , compatible with
predictions from stellar population synthesis models. Assuming minimal IGM
absorption, this ratio corresponds to a relative (absolute) escape fraction of
% (%). The stellar
population fit to MD5b indicates an age of Myr, which is in the
youngest 10% of the sample and the youngest third of typical
Lyman break galaxies, and may be a contributing factor to its LyC detection. We
obtain a revised, contamination-free estimate for the comoving specific
ionizing emissivity at , indicating (with large uncertainties) that
star-forming galaxies provide roughly the same contribution as QSOs to the
ionizing background at this redshift. Our results show that foreground
contamination prevents ground-based LyC studies from obtaining a full
understanding of LyC emission from star-forming galaxies. Future
progress in direct LyC searches is contingent upon the elimination of
foreground contaminants through high spatial-resolution observations, and upon
acquisition of sufficiently deep LyC imaging to probe ionizing radiation in
high-redshift galaxies.Comment: 31 pages, 5 tables, 19 figures. Accepted to ApJ. Version with
full-resolution figures is available at:
http://www.astro.ucla.edu/~aes/Mostardi_HST_LyC.pd
Abnormal infant islet morphology precedes insulin resistance in PCOS-like monkeys.
Polycystic ovary syndrome (PCOS) is prevalent in reproductive-aged women and confounded by metabolic morbidities, including insulin resistance and type 2 diabetes. Although the etiology of PCOS is undefined, contribution of prenatal androgen (PA) exposure has been proposed in a rhesus monkey model as premenopausal PA female adults have PCOS-like phenotypes in addition to insulin resistance and decreased glucose tolerance. PA female infants exhibit relative hyperinsulinemia, suggesting prenatal sequelae of androgen excess on glucose metabolism and an antecedent to future metabolic disease. We assessed consequences of PA exposure on pancreatic islet morphology to identify evidence of programming on islet development. Islet counts and size were quantified and correlated with data from intravenous glucose tolerance tests (ivGTT) obtained from dams and their offspring. Average islet size was decreased in PA female infants along with corresponding increases in islet number, while islet fractional area was preserved. Infants also demonstrated an increase in both the proliferation marker Ki67 within islets and the beta to alpha cell ratio suggestive of enhanced beta cell expansion. PA adult females have reduced proportion of small islets without changes in proliferative or apoptotic markers, or in beta to alpha cell ratios. Together, these data suggest in utero androgen excess combined with mild maternal glucose intolerance alter infant and adult islet morphology, implicating deviant islet development. Marked infant, but subtle adult, morphological differences provide evidence of islet post-natal plasticity in adapting to changing physiologic demands: from insulin sensitivity and relative hypersecretion to insulin resistance and diminished insulin response to glucose in the mature PCOS-like phenotype
On the physics and technology of gaseous particle detectors
Despite an already long and fruitful history, gaseous elementary-particle
detectors remain today an important mainstay of high-energy and nuclear physics
experiments and of radiation detection in general. In here we briefly describe
some of the gaseous detector's main technologies and applications, along with
some unsolved gas-discharge physics aspects of practical relevance.Comment: Submitted to Plasma Sources in Science and Technolog
Early affective changes and increased connectivity in preclinical Alzheimer's disease.
IntroductionAffective changes precede cognitive decline in mild Alzheimer's disease and may relate to increased connectivity in a "salience network" attuned to emotionally significant stimuli. The trajectory of affective changes in preclinical Alzheimer's disease, and its relationship to this network, is unknown.MethodsOne hundred one cognitively normal older adults received longitudinal assessments of affective symptoms, then amyloid-PET. We hypothesized amyloid-positive individuals would show enhanced emotional reactivity associated with salience network connectivity. We tested whether increased global connectivity in key regions significantly related to affective changes.ResultsIn participants later found to be amyloid positive, emotional reactivity increased with age, and interpersonal warmth declined in women. These individuals showed higher global connectivity within the right insula and superior temporal sulcus; higher superior temporal sulcus connectivity predicted increasing emotional reactivity and decreasing interpersonal warmth.ConclusionsAffective changes should be considered an early preclinical feature of Alzheimer's disease. These changes may relate to higher functional connectivity in regions critical for social-emotional processing
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