Useage of Intra-aortic Baloon Pump in the Open Heart Surgeries [Acik Kalp Ameliyatlarinda Intra-Aortik Balon Pompasi Kullanilmasi]

In recent years, by means of advances in cardiology and cardiovascular surgery, morbidity and mortality rates related to cardiac disease are declining. IABP which is used particularly in the treatment of low cardiac output syndrome has found area of application widely in a short time, and still is the most widely used device among the ventricular assist devices in the world. [Med-Science 2015; 4(3.000): 2593-609

Adjunctive Hyperbaric Oxygen Therapy or Alone Antibiotherapy? Methicillin Resistant Staphylococcus aureus Mediastinitis in a Rat Model

ABSTRACT OBJECTIVE: In the post-sternotomy mediastinitis patients, Staphylococcus aureus is the pathogenic microorganism encountered most often. In our study, we aimed to determine the efficacy of antibiotic treatment with vancomycin and tigecycline, alone or in combination with hyperbaric oxygen treatment, on bacterial elimination in experimental S. aureus mediastinitis. METHODS: Forty-nine adult female Wistar rats were used. They were randomly divided into seven groups, as follows: non-contaminated, contaminated control, vancomycin, tigecycline, hyperbaric oxygen, hyperbaric oxygen + vancomycin and hyperbaric oxygen + tigecycline. The vancomycin rat group received 10 mg/kg/day of vancomycin twice a day through intramuscular injection. The tigecycline group rats received 7 mg/kg/day of tigecycline twice a day through intraperitoneal injection. The hyperbaric oxygen group underwent 90 min sessions of 100% oxygen at 2.5 atm pressure. Treatment continued for 7 days. Twelve hours after the end of treatment, tissue samples were obtained from the upper part of the sternum for bacterial count assessment. RESULTS: When the quantitative bacterial counts of the untreated contaminated group were compared with those of the treated groups, a significant decrease was observed. However, comparing the antibiotic groups with the same antibiotic combined with hyperbaric oxygen, there was a significant reduction in microorganisms identified (P<0.05). Comparing hyperbaric oxygen used alone with the vancomycin and tigecycline groups, it was seen that the effect was not significant (P<0.05). CONCLUSION: We believe that the combination of hyperbaric oxygen with antibiotics had a significant effect on mediastinitis resulting from methicillin-resistant Staphylococcus aureus. Methicillin-resistant Staphylococcus aureus mediastinitis can be treated without requiring a multidrug combination, thereby reducing the medication dose and concomitantly decreasing the side effects

Protective effect of gel form of gastric gavage applicated aloe vera on ischemia reperfusion injury in renal and lung tissue

The aloe vera plant has become increasingly popular in recent years. This study aimed to research the effect of aloe vera to prevent renal and lung tissue damage in an experimental ischemia-reperfusion (I/R) injury model. The study included 21 male Wistar Albino rats, which were categorized into control group, n = 7 (no procedures), Sham group n = 7 (I/R); and aloe vera therapy group, n = 7 (aloe vera and I/R). Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and malondialdehyde (MDA) were evaluated from lung and kidney tissues for biochemical investigations. As histopathological, hematoxylin and eosin and anti-iNOS were also examined. In biochemical investigations, SOD, CAT, and GPx levels of the Sham group were found to be lower compared with the other groups (P < 0.05). The aloe vera therapy group was not statistically different from control groups but significantly different compared with the Sham group. In the same way, the MDA levels of kidney and lung tissues were statistically significant in the aloe vera therapy group, compared to the Sham group. In the Sham group, the peribronchial and perialveolar edema were observed in lung parenchyma. Also, excess interstitial hemorrhage, leukocyte infiltration, and alveolar wall thickening were identified in ischemic groups. The histopathological changes were much lighter than in the aloe vera therapy group. In renal tissues, excess epithelial cell deterioration, tubular desqumination, and glomerular atrophy were observed in the Sham group. The histopathological changes were markedly reduced in the aloe vera therapy group. In the kidney and lung tissue, the level of iNOS activity in the Sham group was significantly higher than in the control and aloe vera therapy group. This study indicated that aloe vera is protective against oxidative damage formed by I/R in distant organs like the lungs and kidneys.Scientific Research Project Department of Canakkale Onsekiz Mart University [TSA-2015-487]We acknowledge Scientific Research Project Department of Canakkale Onsekiz Mart University for the grant given under project code TSA-2015-487

Zależność między fragmentacją zespołów QRS a wynikami w skali SYNTAX i skali Gensiniego u chorych z ostrym zespołem wieńcowym

Background: Fragmented QRS (fQRS) complexes on 12-lead electrocardiography (ECG) have been reported to be predictors of cardiac events and all-cause mortality in coronary artery disease (CAD). Aim: To investigate the relationship between fQRS complexes and SYNTAX and Gensini scores in patients with acute coronary syndrome (ACS). Methods: A total of 302 patients (223 men and 79 women) with ACS (133 ST elevated myocardial infarction [STEMI], 107 non-STEMI [NSTEMI], and 62 unstable angina pectoris [USAP]) were evaluated retrospectively in this study. An fQRS pattern was found in 70 patients (fQRS group) but was not found in 232 patients (non-fQRS group). SYNTAX score &gt; 22 and Gensini score &gt; 20 were defined as high SYNTAX and Gensini scores. The relationship between the presence of fQRS on 12-lead ECG and SYNTAX and Gensini scores was assessed. Results: SYNTAX score (p &lt; 0.001), Gensini score (p &lt; 0.001), NYHA class (p &lt; 0.001), QRS duration (p &lt; 0.001), number of disease vessels (p = 0.003), and high sensitive troponin T levels (p = 0.026) were significantly higher in the fQRS group. The number of fQRS leads (HR 5.79, 95% CI 2.78–12.06, p &lt; 0.001, HR 3.41, 95% CI 1.32–8.78, p = 0.016, respectively) was found to be an independent predictor of high SYNTAX score and high Gensini score in multivariate analysis. Conclusions: The number of fQRS leads on 12-lead ECG on admission is associated with the severity and complexity of CAD in patients with ACS.Wstęp: Jak wskazują doniesienia, fragmentacja zespołów QRS (fQRS) w 12-odprowadzeniowym elektrokardiogramie (EKG) jest czynnikiem predykcyjnym zdarzeń sercowych i zgonu z jakiejkolwiek przyczyny u pacjentów z chorobą wieńcową (CAD). Cel: Celem badania była ocena zależności między fQRS a punktacją w skali SYNTAX i skali Gensiniego u chorych z ostrym zespołem wieńcowym (ACS). Metody: Do badania włączono retrospektywnie 302 chorych (223 mężczyzn i 79 kobiet) z ACS [133 przypadków zawału serca z uniesieniem docinka ST (STEMI), 107 przypadków zawału serca bez uniesienia odcinka ST (NSTEMI) i 62 przypadki niestabilnej dławicy piersiowej (USAP)]. Cechy fQRS stwierdzono u 70 chorych (grupa fQRS), a u 232 osób nie występowały pofragmentowane zespoły QRS (grupa nie-fQRS). Jako wysoką punktację definiowano wynik w skali SYNTAX wynoszący &gt; 22 i wynik w skali Gensiniego wynoszący &gt; 20. Oceniono zależności między obecnością fQRS w 12-odprowadzeniowym EKG a punktacją w skali SYNTAX i skali Gensiniego. Wyniki: Punktacja w skali SYNTAX (p &lt; 0,001), punktacja w skali Gensiniego (p &lt; 0,001), klasa wg NYHA (p &lt; 0,001), czas trwania zespołu QRS (p &lt; 0,001), liczba zmienionych chorobowo naczyń (p = 0,003) i stężenie troponiny T oznaczanej metodą wysokoczułą (p = 0,026) były istotnie większe w grupie fQRS. W analizie wieloczynnikowej wykazano, że liczba odprowadzeń, w których występowały pofragmentowane zespoły QRS (odpowiednio HR 5,79; 95% CI 2,78–12,06; p &lt; 0,001; HR 3,41; 95% CI 1,32–8,78; p = 0,016) była niezależnym czynnikiem predykcyjnym wysokiej punktacji w skali SYNTAX i skali Gensiniego. Wnioski: Liczba odprowadzeń, w których występują pofragmentowane zespoły QRS w 12-odprowadzeniowym EKG wykonanym przy przyjęciu do szpitala, wiąże się ze stopniem ciężkości i złożonością CAD u chorych z ACS.

Ergotamine-induced vasospastic ischemia mimicking arterial embolism: unusual case

WOS: 000344217100012PubMed ID: 25135025Ergotamine toxicity is an important and rare condition, including tachycardia, arterial spasm which occurring as a result of accidental overdosing or drug interactions. We assessed the consequences of delayed diagnosis of peripheral arterial vasoconstriction occurring after simultaneous macrolide use by a 35-year-old woman using an ergot-derived drug for migraine. Diagnosis of ergotamine intoxication begins with suspicion. Interventional radiologists and surgeons should be aware of this acute dangerous condition