Pyridazine and its related compounds. Part 35 [1]: Synthesis, characterization and antimicrobial activity of some novel pyridazine and triazolopyridazine containing sulfonamides

The present study describes the chemical synthesis and antimicrobial evaluation of some new pyridazine and triazolopyridazine derivatives. The structure assignments of the new compounds are based on chemical and spectroscopic evidences. The Study results showed that derivatives 6a, 6b, 6g and 6i have promising inhibitory activity against (Micrococcus luteus). Compound 6i has also noticeable inhibition activity against (Escherichia coli) and compound 3g show remarkable activity against (Candida albicans). Rest of compounds showed moderate to low activity against the examined microorganisms

Pyridazine derivatives and its related compounds. Part 31. Synthesis of some disperse dyes derived from 3-amino-1H-pyrzolo[3,4-c]pyridazine and their color assessment on polyester fabrics

The 6-methyl-3, 4-diphenyl-7-(2-phenylhydrazono) pyrimido [1', 2':1, 5] pyrazolo [3,4-c] pyridazin-8(7H)-one and 3,4-diphenyl-7-(phenyldiazenyl)pyrimido[1',2':1,5]pyrazolo[3,4-c]pyridazine-6,8-diamine derivatives were applied to polyester fiber as disperse dyes. They were found to exhibit varying in hue from orange-yellow to orange-red, their absorption spectral characteristics, fastness properties and colour assessment are also reported

Получение препаратов энтомопатогенных нематод и оценка их эффективности

Results about invasion activity of 3 kinds entomopathogenic nematodes from family Steinernema (S. feltiae, S. carpocapsae, S. glaseri ) concerning 2 pest insects of a cotton (cotton scoops Spodoptera littoralis and a cotton bug - Pectinophora gossypiella) and house fly (M. domestica) is analyzed. It is found that the greatest efficiency in the relation larvae stages of pests is S. feltiae. Pupae, in general, were less susceptible to nematode infestation.В статье анализируются данные об инвазионной активности 3-х видов энтомопатогенных нематод из рода Steinernema (S. carpocapsae, S. feltiae и S. glaseri) в отношении различных стадий 2-х вредителей хлопчатника: хлопковой совки (Spodoptera littoralis) и хлопковой моли (Pectinophora gossypiella), а также в отношении личинок комнатной мухи (Musca domestica). Найдено, что наибольшей эффективностью в отношении личиночных стадий вредителей обладает вид S. feltiaе, затем S. carpocapsae и S. glaseri. Куколки в целом оказались менее восприимчивы к инвазии нематод

Pyridazine and its related compounds: Part 33. Synthesis of some disperse dyes derived from 3-hydrazinyl-4,5-diphenyl-1H-pyrazolo[3,4-c]pyridazine and their color assessment on polyester fabric

Active methylene compound such as ethyl acetoacetate was coupled with diazotized arylamines to give ethyl arylazoacetoacetates. When the obtained compounds refluxed with 3-hydrazinyl-4,5-diphenyl-1H-pyrazolo[3,4-c]pyridazine in the presence of ethanol yielded 1-(4, 5-Diphenyl-1H-pyrazolo[3, 4-c]pyridazin-3-yl)-3-methyl-4-(2-phenylhydrazono)-1H-pyrazol-5(4H)-one derivatives. The dyes were applied to polyester fabric, and their absorption spectral characteristics, fastness properties and color assessment measured

Tissue microarrays and their use for preparation of reference slides for educational purposes in histology and histopathology

Use of Tissue array was first applied in 1998, and has received a significant amount of attention from the research community ever since. In this technique, a large number (up to 1000) of cylindrical tissue core extracted from \"donor\" paraffin block are deposited into \"recipient\" block. The aim was modification of the technique of tissue array for manual preparation of the recipient block and production of slides of educational interest in histology and histopathology. The area of interest was localized with the help of stained section, the area was punctured, and the cylindrical core of tissue removed was then introduced into another (recipient) paraffin block. Puncture method was suitable only for parenchymatous organs (liver, kidney, heart, spleen, etc.) but longitudinal sections were required for tubular (gastrointestinal tract, urinary tract, genital tract) and hollow organs (gallbladder, urinary bladder) and brain. The method described is of importance in procurement of materials for preparation of slides for educational purposes and in overcoming the shortage of these materials especially in the field of pathology African Journal of Health Sciences Vol. 13 (3-4) 2006: pp. 66-6

Pyridazine and its related compounds: Part 32. Synthesis and antimicrobial evaluation of some 3-substituted amino-4,5,6-triphenylpyridazine derivatives

3-Amino-4,5,6-triphenylpyridazine was subjected to some selected reactions with nitrous acid, formic acid/dimethylformamide, acetic anhydride, benzoyl chloride, chloroacetyl chloride, acetaldehyde, diethyl malonate, malonic acid/phosphoryl chloride, diethyl oxalate, ethyl cyanoacetate, ethyl acetoacetate, and ethyl benzoylacetate to give new 3-substituted aminopyridazine derivatives. A few sulfonamide derivatives (new) were also prepared. The structures of the synthesized compounds were proved by their infrared, mass spectra, 1H NMR, and elemental analysis. The antimicrobial activity of the compounds obtained was examined against some selected microorganisms

Pyridazine and its related compounds: Part 38. Pyrimido[1,2-b]pyridazinone, synthesis and some reactions

A new method of generating the fused heterocyclic system with bridge head nitrogen pyrimido[1,2-b]pyridazinone, from 3-amino-4,5,6-triphenylpyridazine and malonic acid in presence of phosphoryl chloride is described. The structures of the synthesized compounds were confirmed by their infrared, mass spectrum, 1H NMR and elemental analyses. The antimicrobial activity of the compounds obtained was examined against some selected microorganisms

1-[(Cyclo­propyl­meth­oxy)meth­yl]-5-ethyl-6-(4-methyl­benzyl)-1,2,3,4-tetra­hydro­pyrimidine-2,4-dione

The pyrimidine ring in the title compound, C19H24N2O3, is nearly planar (r.m.s. deviation = 0.008 Å); the C atom at the 5-position deviates by 0.054 (3) Å from the mean plane and the C atom at the 6-position by 0.006 (3) Å in the opposite direction. The benzene ring is approximately perpendicular to the pyrimidine ring [dihedral angle = 83.90 (10)°]. The amino group is hydrogen-bond donor to the exocyclic O atom at the 2-position of an adjacent mol­ecule, the hydrogen bond generating an inversion dimer. The cyclo­propyl ring is disordered over two sets of sites with the major component having 71.5 (4)% occupancy

2-[(2-Meth­oxy­eth­yl)sulfan­yl]-4-(2-methyl­prop­yl)-6-oxo-1,6-dihydro­pyrimidine-5-carbonitrile

In the title compound, C12H17N3O2S, the 4-methyl-2-methyl­sulfanyl-6-oxo-1,6-dihydro­pyrimidine-5-carbonitrile part of the mol­ecule is almost planar (r.m.s deviation = 0.062 Å). In the crystal, mol­ecules form centrosymmetric dimers via pairs of N—H⋯O hydrogen bonds