3 research outputs found
Access to a Structurally Complex Compound Collection via Ring Distortion of the Alkaloid Sinomenine
Many compound collections used in
high-throughput screening are
composed of members whose structural complexity is considerably lower
than that of natural products. We previously reported a strategy for
the synthesis of complex and diverse small molecules from natural
products using ring-distortion reactions, called complexity-to-diversity
(CtD), and herein, CtD is applied in the synthesis of 16 diverse scaffolds
and 65 total compounds from the alkaloid natural product sinomenine.
Chemoinformatic analysis shows that these compounds possess complex
ring systems and marked three-dimensionality
Analysis of cyclist peloton configuration on two-lane rural roads
This article is part of the Proceedings of the 6th Annual International Cycling Safety Conference held in Davis, California, USA on September 20th through 23rd in the year 2017.<br><br>Paper ID: 6
Downgrading Recent Estimates of Land Available for Biofuel Production
Recent estimates of additional land available for bioenergy
production
range from 320 to 1411 million ha. These estimates were generated
from four scenarios regarding the types of land suitable for bioenergy
production using coarse-resolution inputs of soil productivity, slope,
climate, and land cover. In this paper, these maps of land availability
were assessed using high-resolution satellite imagery. Samples from
these maps were selected and crowdsourcing of Google Earth images
was used to determine the type of land cover and the degree of human
impact. Based on this sample, a set of rules was formulated to downward
adjust the original estimates for each of the four scenarios that
were previously used to generate the maps of land availability for
bioenergy production. The adjusted land availability estimates range
from 56 to 1035 million ha depending upon the scenario and the ruleset
used when the sample is corrected for bias. Large forest areas not
intended for biofuel production purposes were present in all scenarios.
However, these numbers should not be considered as definitive estimates
but should be used to highlight the uncertainty in attempting to quantify
land availability for biofuel production when using coarse-resolution
inputs with implications for further policy development