Henri Temianka Correspondence; (gottschalk)

This collection contains material pertaining to the life, career, and activities of Henri Temianka, violin virtuoso, conductor, music teacher, and author. Materials include correspondence, concert programs and flyers, music scores, photographs, and books.https://digitalcommons.chapman.edu/temianka_correspondence/3528/thumbnail.jp

Public research spin-offs in Germany: Summary report

The growing importance of knowledge and the ensuing need to translate research results, and especially new scientific findings as quickly as possible into economic activities are drawing the attention of academia and politicans increasingly towards what is referred to as academic spin-off formations. These business foundations from higher education institutions and off-campus research facilities are a route to knowledge and technology transfer, which can ensure that the research results gathered in these facilities are transferred directly into marketable products or processes. Policymakers are expected to create favourable framework conditions for the formation of spin-offs. Several initiatives of the Federal State and Länder (e.g. the EXIST Programme of the BMBF) were started with the express goal of promoting and aiding such new businesses. --

Spinoff-Gründungen aus der öffentlichen Forschung in Deutschland

Die wachsende Bedeutung von Wissen und die daraus resultierende Notwendigkeit, neue, insbesondere auch wissenschaftliche Erkenntnisse möglichst schnell in wirtschaftliche Aktivitäten umzusetzen, lenkt die Aufmerksamkeit von Wissenschaft und Politik verstärkt auf so genannte akademische Spinoff-Gründungen. Diese Unternehmensgründungen aus Hochschulen und außeruniversitären Forschungseinrichtungen sind ein Weg des Wissens und Technologietransfers, der sicherstellen kann, dass die dort erarbeiteten Erkenntnisse ohne große Umwege in marktfähige Produkte oder Verfahren münden. Von der Politik wird erwartet, dass sie günstige Rahmenbedingungen für Spinoff-Gründungen schafft. Die Stimulierung und Unterstützung derartiger Gründungen ist das erklärte Ziel etlicher Initiativen von Bund und Ländern, wie beispielsweise des EXIST-Programms des BMBF

Extract From a Letter From Alfred Gottschalk to Herbert C. Hengstler, April 28, 1910

The document is an extract of a typed letter from Alfred L.M. Gottschalk to Herbert C. Hengstler concerning the current activities and whereabouts of Charles Richard Crane.https://digitalcommons.ursinus.edu/fmhw_crane/1009/thumbnail.jp

DAF-12 Regulates a Connected Network of Genes to Ensure Robust Developmental Decisions

The nuclear receptor DAF-12 has roles in normal development, the decision to pursue dauer development in unfavorable conditions, and the modulation of adult aging. Despite the biologic importance of DAF-12, target genes for this receptor are largely unknown. To identify DAF-12 targets, we performed chromatin immunoprecipitation followed by hybridization to whole-genome tiling arrays. We identified 1,175 genomic regions to be bound in vivo by DAF-12, and these regions are enriched in known DAF-12 binding motifs and act as DAF-12 response elements in transfected cells and in transgenic worms. The DAF-12 target genes near these binding sites include an extensive network of interconnected heterochronic and microRNA genes. We also identify the genes encoding components of the miRISC, which is required for the control of target genes by microRNA, as a target of DAF-12 regulation. During reproductive development, many of these target genes are misregulated in daf-12(0) mutants, but this only infrequently results in developmental phenotypes. In contrast, we and others have found that null daf-12 mutations enhance the phenotypes of many miRISC and heterochronic target genes. We also find that environmental fluctuations significantly strengthen the weak heterochronic phenotypes of null daf-12 alleles. During diapause, DAF-12 represses the expression of many heterochronic and miRISC target genes, and prior work has demonstrated that dauer formation can suppress the heterochronic phenotypes of many of these target genes in post-dauer development. Together these data are consistent with daf-12 acting to ensure developmental robustness by committing the animal to adult or dauer developmental programs despite variable internal or external conditions

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival