10 research outputs found
CD34 Expression in the Stromal Cells of Alveolar Adenoma
The alveolar adenoma of the lung is a rare benign tumor characterized by a proliferation of both the alveolar epithelial cells and the mesenchymal septal cells. Immunohistochemically, the epithelial cells stain for cytokeratin (CK) AE1AE3, CK7, thyroid transcription factor 1 (TTF1), and surfactant apoprotein confirming the derivation by the type 2 pneumocytes. The stromal cells are negative for these markers but they show focally smooth muscle and muscle-specific actin positivity.
We describe two cases that showed immunohistochemically a CD34 positivity of the mesenchymal septal cells. This aspect has been previously described in a two cases report, but not emphasized by the authors as a distinctive feature of the lesion. We consider this CD34 positivity as a marker of immaturity or stemness of the lesional septal spindle cells, that could be responsible of the different phenotypic and morphological profile of the interstitial cells, that could be, therefore, considered neoplastic and not reactive
Atherogenic dyslipidemia on admission is associated with poorer outcome in people with and without diabetes hospitalized for COVID-19
Identifying metabolic factors associated with critical disease can help to improve management of patients hospitalized for coronavirus disease 2019 (COVID-19). High triglycerides and low HDL levels characterize the atherogenic dyslipidemia closely related to insulin resistance and diabetes. We examined associations of atherogenic dyslipidemia detected on admission with outcome of COVID-19 during hospitalization
Processi BIM-Oriented 3d-4d-5dâ per il Project construction management.
Building Information Modeling non Ăš il nome di un software,
non Ăš neanche la mera rappresentazione grafica tridimensionale
di un elaborato, ma Ăš un concetto ben piĂč ampio che abbraccia a
trecentosessanta gradi ogni fase del processo edilizio dalla programmazione
alla gestione dellâopera. La tanto acclamata informatizzazione
del processo Ăš stata contestualizzata analizzando
lâevoluzione dellâapproccio progettuale e gestionale attraverso la
modellazione di un edificio con destinazione dâuso residenziale
che vede la sua struttura portante su tre diverse tecnologie costruttive,
il cemento armato, lâacciaio ed il legno lamellare
Building Information Modeling (BIM). Great Misunderstanding or Potential Opportunities for the Design Disciplines?
The BIM universe will undoubtedly arouse great and diversified interests amongst actors involved in the design/building process but also of scholars dealing with representation disciplines. The BIM systems appear in fact particularly suitable to respond to both needs providing on a single platform analytic tool, visualization interfaces, assessment instruments but also a bundle for the representation of reality. And, in addition to that, always taking into account the management of the process in terms of timing that is a key element for a correct handling of any building workflow. Nevertheless, the urgency of optimization of time and resources will drive very rapidly this change achieving, eventually, the real result: an evolution of future generation professionals, more willing and able to cooperate beyond personal skills
Cobalt chloride has beneficial effects across species through a hormetic mechanism
: Severe oxygen and iron deficiencies have evolutionarily conserved detrimental effects, leading to pathologies in mammals and developmental arrest as well as neuromuscular degeneration in the nematode Caenorhabditis elegans. Yet, similar to the beneficial effects of mild hypoxia, non-toxic levels of iron depletion, achieved with the iron chelator bipyridine or through frataxin silencing, extend C. elegans lifespan through hypoxia-like induction of mitophagy. While the positive health outcomes of hypoxia preconditioning are evident, its practical application is rather challenging. Here, we thus test the potential beneficial effects of non-toxic, preconditioning interventions acting on iron instead of oxygen availability. We find that limiting iron availability through the iron competing agent cobalt chloride has evolutionarily conserved dose-dependent beneficial effects: while high doses of cobalt chloride have toxic effects in mammalian cells, iPS-derived neurospheres, and in C. elegans, sub-lethal doses protect against hypoxia- or cobalt chloride-induced death in mammalian cells and extend lifespan and delay age-associated neuromuscular alterations in C. elegans. The beneficial effects of cobalt chloride are accompanied by the activation of protective mitochondrial stress response pathways
The best prostate biopsy sampling systemâfusion and systematic biopsy: A single center experience
Background: Prostate cancer is the second most commonly diagnosed cancer in men. The diagnostic accuracy in prostate cancer can be increased by employing a preliminary multiparametric MRI followed by a fusion-targeted biopsy.
Methods: To compare the diagnostic accuracy of fusion-targeted biopsy with the standard systematic biopsy in prostate cancer patients, we enrolled 139 patients on which we performed 139 prostate biopsies consisting of three targeted samples followed by 12 regular systematic samples. Based on histology, we analyzed the diagnostic performance of the two methods.
Results: Both methods were equally good at detecting clinically significant cancer (83.3%, 50/60), while systematic biopsy detected more clinically insignificant cancers. However, the best diagnostic performance is obtained by combining the two methods.
Conclusion: The two methods are best seen as synergistic, and the addition of fusion biopsy can be used to detect more clinically significant prostate cancers than systematic biopsy alone
Hypocalcemia is associated with adverse outcomes in patients hospitalized with COVID-19
Purpose Calcium ions are involved in the regulation of several cellular processes and may also influence viral replication. Hypocalcemia has been frequently reported during infectious diseases and in critically ill patients, including also COVID-19 patients, significantly related with the pro-inflammatory state and mortality. The aim of this study is to investigate the prevalence of hypocalcemia at admission in patients hospitalized for COVID-19 (Coronavirus disease 2019) and to evaluate association of hypocalcemia with in-hospital COVID-19 outcomes. Methods Retrospective analysis on 118 consecutive patients, hospitalized for COVID-19 between March and May 2020. Clinical characteristics, inflammation markers, biochemical routine and mineral metabolism parameters at admission were collected. Hypocalcemia was defined as total serum calcium <2.2 mmol/L. Population was stratified by tertiles of total serum calcium. Primary outcome was the composite of in-hospital death or admission to intensive care unit (ICU). Secondary outcomes included in-hospital death, admission to ICU and need for non-invasive ventilation as separate events. Associations were tested by logistic regression and Cox-regression analysis with survival curves. Results Overall prevalence of hypocalcemia was 76.6%, with just 6.7% of patients reporting levels of 25-(OH)-vitamin D > 30 ng/ml. Total serum calcium was inversely related with selected inflammatory biomarkers (p < 0.05) and poorer outcome of COVID-19 during hospitalization. Lower tertile of total calcium (<= 2.02 mmol/L) had increased risk of in-hospital mortality (HR 2.77; 1.28-6.03, p = 0.01) compared with other groups. Conclusion Total serum calcium detected on admission is inversely related with proinflammatory biomarkers of severe COVID-19 and is useful to better define risk stratification for adverse in-hospital outcome
«Figure» e «October»: confronti sulla critica dâarte negli anni â80
Sebbene non ci siano stati contatti diretti tra le due redazioni, un progetto comune lega, almeno idealmente, la rivista «Figure. Teoria e Critica dellâarte» fondata da Filiberto Menna nel 1982 e la rivista «October» fondata nel 1976 da Rosalind Krauss e Annette Michelson. Attraverso la ricognizione dei discorsi che hanno caratterizzato negli anni Ottanta la prospettiva critica offerta dai due differenti progetti editoriali il saggio misura le direzioni e i comuni modelli. Le riviste, tanto lontane e tanto vicine, sono accomunate da una spontanea condivisione di problemi, indagini metodologiche e riferimenti che permettono di situare entrambe al centro del dibattito sull'arte postmoderna