Comparing trastuzumab-related cardiotoxicity between elderly and younger patients with breast cancer : a prospective cohort study

OBJECTIVE: Trastuzumab is an HER-2 targeted humanized monoclonal antibody that significantly improves metastatic and non-metastatic breast cancer therapeutic outcomes. This study compares trastuzumab outcomes between two age cohorts in the Kuwait Cancer Control Centre (KCCC). PATIENTS AND METHODS: In a prospective comparative observational study, 93 HER-2 positive breast cancer patients undergoing different chemotherapy protocols + trastuzumab between April 2016 and April 2019 were included and divided into two cohorts based on their age (<60 and ≥60 years old). The individual decline in the LVEF from the baseline was calculated and compared between the two age cohorts. Logistic regression analysis was applied to investigate the association between age, comorbidities, BMI, anthracycline treatment, and baseline LVEF value, and trastuzumab-induced cardiotoxicity after adjustments made for the disease stage. RESULTS: The median baseline LVEF was 65% in both age cohorts (IQR 8% and 9% for older and younger patients, respectively). Whereas the median LVEF post-trastuzumab treatment was 51% and 55% in older and younger patients, respectively (IQR 8%; p-value = 0.22), even though older patients had significantly lower exposure to anthracyclines compared to younger patients (60% and 84.1%, respectively; p-value <0.001). 86.7% and 55.6% of older and younger patients, respectively, developed ≥10% decline in their LVEF from the baseline. Statistically, age was the only factor that significantly correlated with developing ≥10% decline in the LVEF (OR 4; p-value <0.012). CONCLUSIONS: Breast cancer patients aged 60 years and above in Kuwait were at a 4-fold higher risk of developing ≥10% decline in their LVEF from the baseline value compared to younger patients during trastuzumab treatment. Previous exposure to anthracyclines and comorbidities were not associated with a significantly increased cardiotoxicity risk in this study

Antologi Strategi Pembelajaran Jasmani Olahraga Kesehatan di Masa Pandemi

Pendidikan jasmani merupakan bagian integral pada semua tingkat satuan pendidikan, baik dari tingkat sekolah dasar, menengah hingga pendidikan tinggi. Tujuan pendidikan tidak hanya sekedar capaian jasmani nya saja, melainkan bersifat menyeluruh. Hal ini menunjukkan bahwa pendidikan jasmani memiliki kedudukan yang penting dalam pembelajaran, sehingga harus dilaksanakan dengan seksama. Maka dari itu, pembelajaran yang kelak akan disampaikan oleh calon-calon pengajar yang duduk di Peguruan Tinggi, khususnya mahasiswa Program Studi Pendidikan Jasmani Kesehatan dan Rekreasi (PJKR) perlu memahami berbagai cara dan strategi agar tujuan pembelajaran tercapai, khususnya pada era milenial dan pada masa pandemic saat ini. Penyusunan materi pada modul Strategi Pembelajaran Pendidikan Jasmani ini berdasarkan beberapa rujukan dari beberapa materi yang telah disusun oleh para pakar pendidikan, khusunya dalam pendidikan olahraga, pendidikan jasmani dan pendidikan lainnya dalam lingkup tingkat satuan pendidikan mendasar dan menengah hingga pendidikan tinggi, yang kemudian diteliti oleh para mahasiswa PJKR selama perkuliahan. Sehingga antologi modul ini adalah kumpulan hasil penelitian dari para mahasiswa PJKR di lingkungan FKIP Universitas Suryakancana pada semester genap 2020/2021