Dependence of ChTL activity difference in tumor and adjacent tissue on ChTL activity in breast samples.

<p>(A) F(1) = 519.763; <i>p</i><0.001. (B) F(1) = 0.947; <i>p</i> = 0.333. Calculated at 95% confidence.</p

Statistical indicators for revealed dependence of the proteasome parameters in breast samples on simultaneous effect of clinical-pathological factors.^1.

1<p>Multiple GLM (generalized linear models) analysis was applied;</p>2<p>F (DF), F-test value for indicated pair of interacting signs (Degrees of Freedom);</p>3<p><i>p</i>, statistical significance of observed effects.</p><p>Statistical indicators for revealed dependence of the proteasome parameters in breast samples on simultaneous effect of clinical-pathological factors.^1.</p

Regulatory network between ERα and proteasome immune subunit LMP2 in breast cancer.

<p>MIR, microRNA; SOX4, PU.1 (SPI 1), MYC, transcription factors. Created within open informatics site MirOB, (<a href="http://mirob.interactome.ru/pathway_navigator" target="_blank">http://mirob.interactome.ru/pathway_navigator</a>, 2012−2013).</p

Expression of proteasome immune subunits and Rpt6 subunit in breast samples at different disease stages.

<p>Western-blotting was performed with the use of mouse mAbs to proteasome subunits LMP2, LMP7 and Rpt6; β-actin was detected as the inner control with the use of mouse mAbs to this protein. TT, tumor tissue. AT, adjacent tissue.</p

Dependence of amount of proteasome subunits in breast samples on simultaneous effect of two factors.

<p>TT, tumor tissue. AT, adjacent tissue. Factors: lymph node metastasis and histological tumor type. Wilks lambda = 0.014; F(40; 77.7) = 4.02; <i>p</i><0.001. IDC, invasive ductal carcinoma. ILC, invasive lobular carcinoma. MdC, medullary cancer. McC mucinous cancer. Vertical bars denote 95% confidence interval.</p

Expression of immune subunits LMP2 and LMP7 in cytokeratin 18 containing cells of IDC sample.

<p>(Panels A) Mouse mAbs to cytokeratin 18, rabbit pAbs to LMP2. (Panels B) Mouse mAbs to cytokeratin 18, rabbit pAbs to LMP7. IDC, invasive ductal carcinoma. Scale bar, 100 µm.</p

Confocal images of cells in slices of IDC after double immunofluorescent labeling.

<p>(Panel A) Rabbit pAbs to LMP7 subunit and mouse mAbs to α1,2,3,5,6,7 subunits. (Panel B) Rabbit pAbs to LMP7 subunit and mouse mAbs to Rpt6 subunit. IDC, invasive ductal carcinoma. Scale bar, 100 µm.</p