Performance of bundle compliance.

<p>CVP – Central venous pressure.</p><p>ScvO² - Central venous oxygen saturation.</p><p>IPP – Inspiratory Plateau Pressure.</p

Demographic and clinical characteristics of severe sepsis and septic shock patients.

<p>SD - Standard Deviation.</p

Characteristics of the patients with CR-BSI.

<p>CVC = central venous catheter; SAPS II = simplified acute physiology score; SOFA = Sepsis-related Organ Failure Assessment; APACHE II = Acute Physiology and Chronic Health disease Classification System II, Charlson = comorbidity index.</p

Microbiological features by diagnostic method.

<p>Microbiological features by diagnostic method.</p

Risk factors for in-hospital mortality.

<p>CVC = central venous catheter; SAPS II = simplified acute physiology score; SOFA = Sepsis-related Organ Failure Assessment; APACHE II = Acute Physiology and Chronic Health disease Classification System II, Charlson = comorbidity index.</p

Risk factors associated with inadequate antimicrobial therapy in patients with severe sepsis or septic shock patients who had documented bloodstream infection.

<p>OR  =  Odds Ratio; CI  =  Confidance Interval; APACHE  =  Acute Physiology and Chronic Health Evaluation II.</p><p><b>ESKAPE  = </b><b><i>Enterococcus, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterobacter spp.</i></b></p><p>Risk factors associated with inadequate antimicrobial therapy in patients with severe sepsis or septic shock patients who had documented bloodstream infection.</p

The most prevalent microorganisms from monomicrobial bloodstream infections and clinical outcome stratified by adequacy of antimicrobial therapy during the study period.

<p>*resistant to fluconazole.</p><p>**resistant to 3rd and 4th generation cephalosporins.</p>#<p>resistant to carbapenems.</p>##<p>resistant to methicillin.</p>###<p>resistant to vancomycin.</p><p>The most prevalent microorganisms from monomicrobial bloodstream infections and clinical outcome stratified by adequacy of antimicrobial therapy during the study period.</p

Risk factors associated with death in all patients with severe sepsis or septic shock.

<p>OR  =  Odds Ratio; CI  =  Confidence Interval; APACHE: Acute Physiology and Chronic Health Evaluation II.</p><p>Risk factors associated with death in all patients with severe sepsis or septic shock.</p

Risk factors associated with death for patients with severe sepsis or septic shock and documented bloodstream infection.

<p>OR  =  Odds Ratio; CI  =  Confidence Interval; APACHE  =  Acute Physiology and Chronic Health Evaluation II.</p><p>Risk factors associated with death for patients with severe sepsis or septic shock and documented bloodstream infection.</p

Comparison between patients with and without positive blood cultures.

<p>163 patients without blood culture collected during the study period.</p><p>Comparison between patients with and without positive blood cultures.</p