L'Avenir de Luchon : journal scientifique, littéraire, annonces et réclames : guide général des baigneurs et des touristes aux eaux thermales, bains de mer de la France et de l'étranger

28 avril 19291929/04/28 (N437)-1929/04/28.Appartient à l’ensemble documentaire : MidiPyren

Immunohistochemistry for Ki-67 expression on the sciatic nerves from the tumor induced and control (untreated) mice indicates that the IL13Rα2 staining pattern was intense in tumor tissue.

<p>Immunohistochemistry for Ki-67 expression on the sciatic nerves from the tumor induced and control (untreated) mice indicates that the IL13Rα2 staining pattern was intense in tumor tissue.</p

IL13Rα2 expression in the sciatic nerve tumor developed in NIHIII mice injected with sNF96.2 NF-1 cells.

<p>The expression levels were compared with the control sciatic nerves which were not injected with the cells.</p

Immunofluorescence of benign and malignant peripheral nerve tumors for IL13Rα2 (red).

<p>The blue color represents the nuclear staining with DAPI. IL13Rα2 expression is evident in MPNST, low grade schwannomas and neurofibromas. From the composite images, most of the staining appears to be cytoplasmic as well as nuclear.</p

Immunohistochemistry for Ki-67 expression on the sciatic nerves from the tumor induced and control (untreated) mice indicates that the IL13Rα2 staining pattern was intense in tumor tissue.

<p>Immunohistochemistry for Ki-67 expression on the sciatic nerves from the tumor induced and control (untreated) mice indicates that the IL13Rα2 staining pattern was intense in tumor tissue.</p

Fluorescent microscopic images of sNF96.2 and ST88-14 MPNST cells after exposure to IL13LIPDXR for 2 hours, followed by immunocytochemistry for IL13Rα2.

<p>The green color in the cytoplasmic region represents the expression of IL13Rα2 receptor and the red color represents the endogenous fluorescence of the internalized doxorubicin delivered through targeted liposomes. (B) IL13LIPDXR is also able to bind and internalize through multicellular spheroids after exposure for 2 hours as evidenced by confocal microscopy images. More details can be found in the <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0181529#pone.0181529.s002" target="_blank">S2 Fig</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0181529#pone.0181529.s004" target="_blank">S1 Video</a>.</p

Serum chemistry analysis.

<p>The analysis was performed 48 hours post injection of the 7mg/kg dose of targeted and non-targeted liposomal doxorubicin. The values were compared with control mice injected with phosphate buffered saline. The levels indicate that liver functional enzymes including bilirubin and alkaline phosphatase are comparable in both the treated and control groups of mice. Creatinine and BUN levels are also comparable to that of untreated control mice, indicating that renal function is not significantly affected due to treatment.</p

IL13Rα2 expression in various tissues from a peripheral nerve carcinoma tissue microarray.

<p>Representative microscopic images from the tissue microarray after IHC for IL13Rα2 expression are shown (panel A-F). Malignant Schwannoma distinctly shows robust expression of IL13Rα2 in the tissue (D) with positive expression in benign neurofibromas as evident from the IHC (E,F). Normal nerve tissue indicated minimal staining without distinct cellular morphology. No IL13Rα2 staining was observed in cancer adjacent normal tissues.</p