The average mean absolute relative error (MARE) across a number of observation times, for the two-compartment network (top panel), the linear four-compartment network (middle panel) and the radial four-compartment network (bottom panel).

<p>Each point is the average for that measure, at that observation time, with error bars representing the standard error.</p

Box plots of MDE corresponding to simulated data for a random set of parameter values (Scenario 4), at a number of different observation times (1, 4 and 8) of the radial model.

<p>The box plots represent 100 parameter estimates corresponding to the 100 simulations, and the red crosses denote the true parameter value.</p

Bivariate distributions of replication and killing rates in liver and spleen, for both naive and live-vaccinated groups.

<p>Blue circles are the MDE values, with the blue (solid) ellipses representing the 95% confidence ellipses calculated using the 1000 bootstrap samples (grey points). The red crosses are the MLE values, with red (dashed) ellipse calculated using the hessian evaluated at the MLE.</p

Bivariate plot of MDE corresponding to simulated data for two different choices of parameter values (Scenario 4 and 12), at a number of different observation times (1, 4 and 8) of the simple, migration birth-death model.

<p>The points represent 100 parameter estimates of <i>r</i>₂ and <i>k</i>₂ corresponding to the 100 simulations, and the red crosses denote the true parameter value.</p

The average mean absolute relative error (MARE) across a number of observation times, for the three-compartment network with migration in both directions between two compartments.

<p>Each point is the average for that measure, at that observation time, with error bars representing the standard error.</p

An efficient moments-based inference method for within-host bacterial infection dynamics - Fig 13

<p>Left: Diagram of each model illustrating the relevant compartments, initial conditions, and rates of interest. Right: MDE parameter estimate (blue dot) with box plots of the bootstrapped parameter estimates, and MLE parameter estimate (red cross) with 95% confidence interval (red bars).</p

Box plots of MDE corresponding to simulated data for two different choices of parameter values (Scenario 4 and 12), at a number of different observation times (1, 4 and 8) of the simple, migration-birth-death model.

<p>The box plots represent 100 parameter estimates corresponding to the 100 simulations, and the red crosses denote the true parameter value.</p

Box plots of MDE corresponding to simulated data for a random set of parameter values, at a number of different observation times of the three compartment model with migration in both directions between two compartments.

<p>The box plots represent 100 parameter estimates corresponding to the 100 simulations, and the red crosses denote the true parameter value.</p

Diagram illustrating the two types of network structure we consider.

<p>Diagram illustrating the two types of network structure we consider.</p

Pairwise comparison of the mean absolute relative error (MARE) achieved by MLE (x axis) or MDE (y axis).

<p>Each dot shows the MARE values for one simulated dataset, grouped by parameter values (colour scale), observation time and sample size (panels). Note that the axes are square-root transformed to improve clarity.</p