Spiro Fused Diterpene–Indole Alkaloids from a Creek-Bottom-Derived <i>Aspergillus terreus</i>

Four metabolites, teraspiridoles A–D (<b>2</b>–<b>5</b>), formed from the merger of a diterpene and modified indole scaffold were obtained from an <i>Aspergillus terreus</i> isolate. The structures and absolute configurations of these natural products were established using NMR, mass spectrometry, Marfey’s method, VCD, and ECD data. Teraspiridole B (<b>3</b>) exhibited weak inhibition of planaria regeneration/survival