Barnes maze test in 6-week-old R6/2 and WT mice.

<p>Latency to reach the virtually target hole and numbers of pokes in the target hole were measured on day 5 (A) and day 12 (B). n = 20 animals/group.</p

HomeCageScan behaviours in R6/2 mice at age 4, 8 and 12 weeks.

<p>(A) Total time spent hanging, (B) grooming and (C) number of jumps, from the HomeCage recording. n = 20 animals/group.</p

Profile of dopamine metabolites in brain of WT and R6/2 mice at 4, 8 and 12 weeks of age.

<p>NS: non significant.</p

Profile of serotonin metabolites in brain of WT and R6/2 mice at 4, 8 and 12 weeks of age.

<p>**p<0.001 compared to WT mice.</p

Relationship between disease severity and pituitary axis function.

<p>Data are <i>β</i> coefficient<i>s</i> of the linear regression. The multivariate linear regression model adjusted for age, sex, neuroleptic treatment, IGFBP3 when IGF-1 was in the model, and BMI when GH was in the model.</p>*<p><i>p</i>≤0.10.</p>**<p><i>p</i>≤0.05.</p>***<p><i>p</i>≤0.01.</p><p>GH, growth hormone; IGF-1, insulin-like growth factor-I; ACTH, adrenocorticotropic hormone; TSH, thyroid stimulating hormone; FT3, free triiodothyronine; FT4, free total thyroxine; LH, luteinizing hormone; FSH, follicle-stimulating hormone; TT, testosterone; TFC, total functional capacity.</p>†<p>Only males were included (110 patients).</p>┤<p>Only patients not taking neuroleptics were included (96 patients).</p

Relationship between body mass index and clinical and hormonal disturbances.

<p>Data are <i>β</i> coefficients (<i>p</i> value) of the linear regression.</p>1<p>adjusted for age and sex.</p>2<p>multivariate analysis including age, sex, and parameters significant in the univariate analysis.</p>*<p><i>p</i>≤0.10.</p>**<p><i>p</i>≤0.05.</p>***<p><i>p</i>≤0.01.</p><p>BMI, body mass index; GH, growth hormone; IGF-1, insulin-like growth factor-I; ACTH, adrenocorticotropic hormone; TSH, thyroid stimulating hormone; FT4, free total thyroxine; FT3, free triiodothyronine.</p

Structure of the antisaccade task.

<p>Participants first fixated on the center of the screen. Afterwards, a blank screen was presented followed by either a green or red central cue instructing participants to either make a pro or antisaccade, respectively.</p

Confusion matrix showing true class labels as well as class labels predicted.

<p>Confusion matrix showing true class labels as well as class labels predicted.</p