5 research outputs found
New Polymorph of Dehydroepiandrosterone Obtained via Cryomodification
A new anhydrous polymorph of dehydroepiandrosterone
(DHEA) is detected
in cryomodified powder samples and designated as form VII. The crystal
structure of form VII is determined from multiphase X-ray powder diffraction
(XRPD) data. Additionally, the unknown crystal structures of anhydrous
form III and the new monohydrated DHEA form designated as form S5
are also determined from multiphase XRPD data. To validate the crystal
structures III, VII, and S5, energy minimization with dispersion-corrected
density functional theory is performed in VASP. An extended list of
the DHEA forms with the known crystal structures, which now covers
anhydrous forms I, II, III, VI, and VII and solvated forms S1, S2,
S4 and S5, allows quantification of DHEA solid-state transformations
to be carried out
Are Hamsters a Suitable Model for Evaluating the Immunogenicity of RBD-Based Anti-COVID-19 Subunit Vaccines?
Currently, SARS-CoV-2 spike receptor-binding-domain (RBD)-based vaccines are considered one of the most effective weapons against COVID-19. During the first step of assessing vaccine immunogenicity, a mouse model is often used. In this paper, we tested the use of five experimental animals (mice, hamsters, rabbits, ferrets, and chickens) for RBD immunogenicity assessments. The humoral immune response was evaluated by ELISA and virus-neutralization assays. The data obtained show hamsters to be the least suitable candidates for RBD immunogenicity testing and, hence, assessing the protective efficacy of RBD-based vaccines