The lattice graph <i>G</i>₆ with indicated vessel radii.

<p>The overall blood flow direction is from left to right.</p

Parameter ranges governing the overall blood flow, the plasma concentration and the active transport of L-Dopa.

<p>The precise values used in each simulation are listed in the figure captions.</p

The drug concentration in the tissue as a function of the distance along the <i>x</i>-axis.

<p>The legend indicates the networks on which the steady states were found. The incoming drug concentration is <i>v</i>₀ = 5 <i>μ</i>M.</p

The total flow rates through several lattice graphs as a function of their average vessel radius.

<p>The dashed lines are the extrapolation from the actually computed flow rates. The legend indicates the pressure drop Δ<i>P</i>.</p

A schematic depiction of the lattice refinement process.

<p>The coarse blue network <i>G</i>₁ is replaced by the finer red network <i>G</i>₂. Both networks fill out the same computational volume. The arrows indicate the direction of the flow through the network.</p

The extrapolated total drug concentration at an exchange area of 120 cm² as a function of the incoming drug concentration <i>v</i>₀.

<p>The extrapolated total drug concentration at an exchange area of 120 cm² as a function of the incoming drug concentration <i>v</i>₀.</p

The radius distributions for the subdivision levels <i>n</i> = 5, 15 and 149 (from right to left).

<p>Note the logarithmic scale on the horizontal axis; the area under each curve is 1.</p

A schematic comparison of blood flow through a large organ <i>(left)</i> and an intermediate size tissue volume <i>(right)</i>.

<p>A schematic comparison of blood flow through a large organ <i>(left)</i> and an intermediate size tissue volume <i>(right)</i>.</p

A simplified model for active drug transport within the capillaries, across the BBB and subsequent metabolism.

<p>The drug is represented by purple circles.</p