Example of applied image analysis.

<p>Axial cMRI scans of a 70-year-old woman with newly diagnosed brain metastases from malignant melanoma (MBM). Conspicuity scores of each MBM are indicated in brackets below the respective lesion. <b>(a)</b> Non-enhanced T1-weighted image, right MBM: conspicuity score (CS) 3, left MBM: CS 1. <b>(b)</b> Contrast-enhanced T1-weighted image, right MBM: CS 3, left MBM: CS 3. <b>(c)</b> T2-weighted image, right MBM: CS 3, left MBM: CS 2. <b>(d)</b> Fast low angle shot 2D susceptibility-weighted imaging (SWI), right MBM: CS 3, left MBM: CS 2. <b>(e)</b> Fluid-attenuated inversion recovery (FLAIR) image, right MBM: CS 2, left MBM: CS 3. <b>(f)</b> Diffusion-weighted image (DWI TRACE), right MBM: CS 3, left MBM: CS 1.</p

MRI systems and contrast media.

<p>MRI systems and contrast media.</p

Mean Conspicuity scores and standard deviations of the six different MRI sequences at first diagnosis MRI.

<p>Abbr.: DWI, Diffusion-weighted image; FLAIR, Fluid-attenuated inversion recovery; SWI, Susceptibility-weighted image; ceT1w, contrast-enhanced T1-weighted image; T2w, T2-weighted image; T1w, native T1-weighted image.</p

Parameters of ROC-curve (AUC, standard error, CI) and univariate analysis (in median and [IQR]) for all perfusion parameters with significant differences.

<p>Parameters of ROC-curve (AUC, standard error, CI) and univariate analysis (in median and [IQR]) for all perfusion parameters with significant differences.</p

Conspicuity scores.

<p>Conspicuity scores.</p

Tmax and CTH maps for three patients.

<p>Each row shows the most representative images of one patient. The first column depicts Tmax, the second CTH maps. Color-coded bars show Tmax and CTH values in seconds, respectively. The first patient (a, b) had perfusion abnormalities in the same region for Tmax and CTH with differing parts of that region being most severely affected. The second patient (c, d) shows a severe Tmax restriction while only slightly elevated CTH values can be seen. In the third patient (e, f) the profile for both Tmax and CTH seems to be comparable in the anterior and posterior middle cerebral artery border zone, while it is different in the temporoparietal region.</p

Contributions to the development of a multi-stage flash/fluidized bed evaporator (msf/fbe)

Mechanical Maritime and Materials Engineerin

Additional file 1: Figure S1. of Time-dependent parameter of perfusion imaging as independent predictor of clinical outcome in symptomatic carotid artery stenosis

CT Angiography of the patient shown in Fig. 2. (TIF 1426 kb

Data_Sheet_1_Differential modulation of resting-state functional connectivity between amygdala and precuneus after acute physical exertion of varying intensity: indications for a role in affective regulation.PDF

IntroductionPhysical activity influences psychological well-being. This study aimed to determine the impact of exercise intensity on psychological well-being and alterations in emotion-related brain functional connectivity (FC).MethodsTwenty young, healthy, trained athletes performed a low- and high-intensity interval exercise (LIIE and HIIE) as well as a control condition in a within-subject crossover design. Before and after each condition, Positive And Negative Affect Scale (PANAS) was assessed as well as resting-state functional MRI (rs-fMRI). Voxel-wise FC was examined for bilateral amygdala seed region to whole-brain and emotion-related anatomical regions (e.g., insula, temporal pole, precuneus). Data analyses were performed using linear mixed-effect models with fixed factors condition and time.ResultsThe PANAS Positive Affect scale showed a significant increase after LIIE and HIIE and a significant reduction in Negative Affect after the control condition. In rs-fMRI, no significant condition-by-time interactions were observed between the amygdala and whole brain. Amygdala-precuneus FC analysis showed an interaction effect, suggesting reduced post-exercise anticorrelation after the control condition, but stable, or even slightly enhanced anticorrelation for the exercise conditions, especially HIIE.DiscussionIn conclusion, both LIIE and HIIE had positive effects on mood and concomitant effects on amygdala-precuneus FC, particularly after HIIE. Although no significant correlations were found between amygdala-precuneus FC and PANAS, results should be discussed in the context of affective disorders in whom abnormal amygdala-precuneus FC has been observed.</p

Asymmetry of Deep Medullary Veins on Susceptibility Weighted MRI in Patients with Acute MCA Stroke Is Associated with Poor Outcome

<div><p>Background and Purpose</p><p>Due to its sensitivity to deoxyhemoglobin, susceptibility weighted imaging (SWI) enables the visualization of deep medullary veins (DMV) in patients with acute stroke, which are difficult to depict under physiological circumstances. This study assesses the asymmetric appearance of prominent DMV as an independent predictor for stroke severity and outcome.</p><p>Materials and Methods</p><p>SWI of 86 patients with acute middle cerebral artery (MCA) stroke were included. A scoring system from 0 (no visible DMV) to 3 (very prominent DMV) was applied for both hemispheres separately. A difference of scores between ipsi- and contralateral side was defined as asymmetric (AMV+). Occurrence of AMV+ was correlated with the National Institute of Health Stroke Scale (NIHSS) Score on admission and discharge, as well as the modified Rankin Scale (mRS) at discharge. Ordinal regression analysis was used to evaluate NIHSS and mRS as predictors of stroke severity, clinical course of disease and outcome.</p><p>Results</p><p>55 patients displayed AMV+ while 31 did not show an asymmetry (AMV–). Median NIHSS on admission was 17 (11–21) in the AMV+ group and 9 (5–15) in the AMV– group (p = 0.001). On discharge median NIHSS was 11 (5–20) for AMV+ and 5 (2–14) for AMV– (p = 0.005). The median mRS at discharge was 4 (3–5) in the AMV+ group and 3 (1–4) in AMV– (p = 0.001). Odds ratio was 3.19 (95% CI: 1.24–8.21) for AMV+ to achieve a higher mRS than AMV– (p = 0.016).</p><p>Conclusion</p><p>The asymmetric appearance of DMV on SWI is a fast and easily evaluable parameter for the prediction of stroke severity and can be used as an additional imaging parameter in patients with acute MCA stroke.</p></div