A review of athletes presenting for medical assistance at the 2011 Ironman South Africa triathlon event

With the increasing popularity all over the world of Ironman triathlon events, the need to determine the type, timing and number of injuries sustained by these triathletes on race day is evident. Also to determine the optimum medical staffing requirements and knowledge during these events is of importance. The Ironman South Africa 2011 (IMSA) took place on the 10 of April of that year. On that day 1742 triathletes started the event and a total of 1477 where able to complete the entire race distance in the time period allowed, (completion rate of 84.8%). Of those athletes competing, a total of 183 (male 155)(87.4%) and 28 (female)(11.3%) presented to the medical facility for treatment. The mean age of the triathletes presenting was 38.73(SD±9.82) years and the mean time of presentation to the facility was 12.35(SD±2.33) hours after the start of the event. Injury prevalence showed exercise associated collapse (EAC) to be the most common presentation at 44.8%. The medical support and staffing was established to fit the temporal model of injuries sustained by non elite Ironman triathletes. This allowed increasing medical staffing in the latter stages of the race when a greater number of athletes were expected to present for medical assistance

Generalised CP and A4A_4 Family Symmetry

We perform a comprehensive study of family symmetry models based on $A_4$ combined with the generalised CP symmetry $H_{\rm{CP}}$. We investigate the lepton mixing parameters which can be obtained from the original symmetry $A_4\rtimes H_{\rm{CP}}$ breaking to different remnant symmetries in the neutrino and charged lepton sectors. We find that only one case is phenomenologically viable, namely $G^{\nu}_{\rm{CP}}\cong Z^{S}_2\times H^{\nu}_{\rm{CP}}$ in the neutrino sector and $G^{l}_{\rm{CP}}\cong Z^{T}_3\rtimes H^{l}_{\rm{CP}}$ in the charged lepton sector, leading to the prediction of no CP violation, namely $\delta_{CP}$ and the Majorana phases $\alpha_{21}$ and $\alpha_{31}$ are all equal to either zero or $\pi$. We then propose an effective supersymmetric model based on the symmetry $A_4\rtimes H_{\rm{CP}}$ in which trimaximal lepton mixing is predicted together with either zero CP violation or $\delta_{CP}\simeq\pm \pi/2$ with non-trivial Majorana phases. An ultraviolet completion of the effective model yields a neutrino mass matrix which depends on only three real parameters. As a result of this, all three CP phases and the absolute neutrino mass scale are determined, the atmospheric mixing angle is maximal, and the Dirac CP can either be preserved with $\delta_{CP}=0,\pi$ or maximally broken with $\delta_{CP}=\pm \pi /2$ and sharp predictions for the Majorana phases and neutrinoless double beta decay.Comment: 38 pages, 3 figure

A rule-based kinetic model of RNA polymerase II C-terminal domain phosphorylation

The complexity ofmany RNA processing pathways is such that a conventional systemsmodelling approach is inadequate to represent all themolecular species involved. We demonstrate that rule-based modelling permits a detailed model of a complex RNA signalling pathway to be defined. Phosphorylation of the RNApolymerase II (RNAPII)C-terminal domain (CTD; a flexible tail-like extension of the largest subunit) couples pre-messenger RNA capping, splicing and 30 end maturation to transcriptional elongation and termination, and plays a central role in integrating these processes. The phosphorylation states of the serine residues of many heptapeptide repeats of the CTD alter along the coding region of genes as a function of distance from the promoter. From a mechanistic perspective, both the changes in phosphorylation and the location atwhich they take place on the genes are a function of the time spent byRNAPII in elongation as this interval provides the opportunity for the kinases and phosphatases to interactwith theCTD.On this basis,we synthesize the available data to create a kinetic model of the action of the known kinases and phosphatases to resolve the phosphorylation pathways and their kinetics.</p

Evaluation of the cutaneous microbiome in psoriasis

Psoriasis, a highly prevalent disease of humans of unknown cause, is a chronic inflammatory disorder primarily involving skin, with distinctive clinical characteristics. With the newly developed tools that facilitate microbiome research, it now is possible to assess whether the cutaneous microbiome plays a role in the pathogenesis of this disorder. Preliminary data from our studies suggest that the cutaneous microbiome in psoriasis is complex and possibly different from normal. To deal with this complexity, we propose to examine the cutaneous microbiome in relation to psoriasis with explorations at several taxonomic and informatic levels. Our overall objective is to examine how changes in the normal cutaneous microbiome contributes to the pathogenesis of psoriasis. Since causality is complex and often difficult to prove, our overall hypothesis is that there are alterations in the cutaneous microbiome in areas of skin affected by psoriasis in comparison with the range observed in clinically unaffected areas, or in healthy persons. We also hypothesize that the characteristics of the microbiome may affect clinical responses to the immunomodulatory agents used to treat psoriasis. An alternative hypothesis is that effective treatment of psoriasis with systemic immunomodulatory agents will not substantially affect the disordered microbial ecosystem. Such observations would provide evidence for the roles of the microbiota in this disorder. Since an important consideration in microbiome research is the optimal level (e.g. phylum, genus, species, strain, gene) at which to examine a scientific question, and we are not yet certain what are the optimal levels for psoriasis, this also will be examined. Our studies of psoriasis should allow development of both approaches and tools that will have general utility for microbiome research. To test our hypothesis, we propose the following specific aims: 1. To understand the cutaneous microbiome species composition overlaying psoriatic lesions; 2. To investigate differences in metagenome content for psoriatic lesions compared to normal skin; 3. To identify differences in the transcriptional profiles of the microbiome and the host between normal skin and psoriatic lesions using high-throughput sequencing; and 4. To estimate the effects of systemic immunomodulatory therapy for psoriasis on microbiome composition. In total, these studies should help us understand the role of the microbiome in psoriasis pathogenesis

Stratigraphic Overview of Palaeogene Tuffs in the Faroe-Shetland Basin, NE Atlantic Margin

Acknowledgements We are very grateful to PGS for generously donating seismic datasets. Seismic interpretation was carried out using IHS Kingdom software, and wells were downloaded from the UK Oil & Gas Common Data Access Welllog interpretation was conducted using Schlumberger Techlog software. D.W. would also like to thank C. Telford for insights regarding the identification of tuffs in ditch cuttings and Total (UK) for material concerning the Vaila Formation. Attendees of VMRC workshops from academia and industry provided important insights into the stratigraphy of the FSB. Finally,D.W.would like to acknowledge the late Robert Knox, without whom our knowledge of North Atlantic explosive volcanism would be considerably poorer. The reviews of P. Reynolds and J. Ólavsdóttir greatly improved the paper. Funding This work is part of D.W.’s PhD research, which is funded by a University of Aberdeen College of Physical Sciences Scholarship.Peer reviewedPostprin

Prediction of Random Incidence Transmission Loss based on Normal Incidence Four-Microphone Measurements

The use of the four-microphone standing wave tube to assess the acoustical properties of sound absorbing materials is becoming increasingly popular. The objective of the present work was to demonstrate that it is possible, under certain conditions, to predict the random incidence transmission loss of sound absorbing materials based on normal incidence measurements in a four-microphone standing wave tube. If a porous material may be modeled as being isotropic and either perfectly rigid or limp, it may be characterized as an effective fluid in terms of its complex density and wave number. The latter quantities may then be used in conjunction with plane wave theories to predict random incidence properties. That procedure is demonstrated here by using two different porous media. Good agreement was found between the estimated and directly measured random incidence transmission losses. The accuracy of the procedure may however, be limited at both low and high frequencies. At low frequencies, the estimated material properties may be affected by the constraint of the sample around its edge. At high frequencies, higher order mode propagation within the sample may affect the results owing to the typically subsonic wave speeds in porous media