Dietary Uncoupling of Gut Microbiota and Energy Harvesting from Obesity and Glucose Tolerance in Mice

The authors gratefully acknowledge Doctoral Training Partnership funding from the BBSRC (M.J.D.) and funding from the Scottish Government (P.J.M., A.W.R., and A.W.W.). We also thank the Centre for Genome-Enabled Biology and Medicine for help with next-generation sequencing and Karen Garden and the Rowett’s Analytical Services for SCFA analysis. SUPPLEMENTAL INFORMATION Supplemental Information includes four figures and two tables and can be found with this article online at https://doi.org/10.1016/j.celrep.2017.10.056.Peer reviewedPublisher PD

Swarm optimization for adaptive phase measurements with low visibility

Adaptive feedback normally provides the greatest accuracy for optical phase measurements. New advances in nitrogen vacancy centre technology have enabled magnetometry via individual spin measurements, which are similar to optical phase measurements but with low visibility. The adaptive measurements that previously worked well with high-visibility optical interferometry break down and give poor results for nitrogen vacancy centre measurements. We use advanced search techniques based on swarm optimisation to design better adaptive measurements that can provide improved measurement accuracy with low-visibility interferometry, with applications in nitrogen vacancy centre magnetometry.Comment: 8 pages, 7 figures, comments welcom

The interplay between radiation pressure and the photoelectric instability in optically thin disks of gas and dust

Previous theoretical works have shown that in optically thin disks, dust grains are photoelectrically stripped of electrons by starlight, heating nearby gas and possibly creating a dust clumping instability, the photoelectric instability (PeI), that significantly alters global disk structure. In the current work, we use the Pencil Code to perform the first numerical models of the PeI that include stellar radiation pressure on dust grains in order to explore the parameter regime in which the instability operates. In models with gas surface densities greater than $\sim$$10^{-4}~\mathrm{g}~\mathrm{cm}^{-2}$, we see a variety of dust structures, including sharp concentric rings and non-axisymmetric arcs and clumps that represent dust surface density enhancements of factors of $\sim$$5-20$ depending on the run parameters. The gas distributions show various structures as well, including clumps and arcs formed from spiral arms. In models with lower gas surface densities, vortices and smooth spiral arms form in the gas distribution, but the dust is too weakly coupled to the gas to be significantly perturbed. In one high gas surface density model, we include a large, low-order gas viscosity, and, in agreement with previous radiation pressure-free models, find that it observably smooths the structures that form in the gas and dust, suggesting that resolved images of a given disk may be useful for deriving constraints on the effective viscosity of its gas. Broadly, our models show that radiation pressure does not preclude the formation of complex structure from the PeI, but the qualitative manifestation of the PeI depends strongly on the parameters of the system. The PeI may provide an explanation for unusual disk morphologies such as the moving blobs of the AU Mic disk, the asymmetric dust distribution of the 49 Ceti disk, and the rings and arcs found in the disk around HD 141569A.Comment: 13 pages, 13 figures; submitted to Ap

Clinical specialty training in UK undergraduate medical schools: A retrospective observational study

Objectives: To determine if increased exposure to clinical specialties at medical school is associated with increased interest in pursuing that specialty as a career after foundation training. Design: A retrospective observational study. Setting: 31 UK medical schools were asked how much time students spend in each of the clinical specialties. We excluded two schools that were solely Graduate Entry, and two schools were excluded for insufficient information. Main outcome measures: Time spent on clinical placement from UK undergraduate medical schools, and the training destinations of graduates from each school. A general linear model was used to analyse the relationship between the number of weeks spent in a specialty at medical school and the percentage of graduates from that medical school entering each of the Core Training (CT1)/Specialty Training (ST1) specialties directly after Foundation Year 2 (FY2). Results: Students spend a median of 85 weeks in clinical training. This includes a median of 28 weeks on medical firms, 15 weeks in surgical firms, and 8 weeks in general practice (GP). In general, the number of training posts available in a specialty was proportionate to the number of weeks spent in medical school, with some notable exceptions including GP. Importantly, we found that the number of weeks spent in a specialty at medical school did not predict the percentage of graduates of that school training in that specialty at CT1/ST1 level (ß coefficient=0.061, p=0.228). Conclusions: This study found that there was no correlation between the percentage of FY2 doctors appointed directly to a CT1/ST1 specialty and the length of time that they would have spent in those specialties at medical school. This suggests that curriculum adjustments focusing solely on length of time spent in a specialty in medical school would be unlikely to solve recruitment gaps in individual specialties

Balancing Efficiency, Equity, and Voice in Workplace Resolution Procedures

Systems for resolving workplace disputes are very important to workers and firms, and have been the subject of much debate. In the United States, traditional unionized grievance procedures, emerging nonunion dispute resolution systems, and the court-based system for resolving employment law disputes have all been criticized. Much of the existing debate on workplace dispute resolution, however, has been atheoretical, with a focus on techniques of dispute resolution rather than the goals of the system. What is missing from the debate are fundamental standards for comparing and evaluating dispute resolutions systems. In this paper, we develop efficiency, equity, and voice as these standards. Unionized, nonunion, and employment law procedures are then evaluated against these three standards.

Wind tunnel tests of modified cross, hemisflo, and disk-gap-band parachutes with emphasis in the transonic range

Transonic wind-tunnel studies were conducted with modified cross, hemisflo, and disk-gap-band parachute models in the wake of a cone-cylinder shape forebody. The basic cross design was modified with the addition of a circumferential constraining band at the lower edge of the canopy panels. The tests covered a Mach number range of 0.3 to 1.2 and a dynamic pressure range from 479 Newtons per square meter to 5746 Newtons per square meter. The parachute models were flexible textile-type structures and were tethered to a rigid forebody with a single flexible riser. Different size models of the modified cross and disk-gap-band canopies were tested to evaluate scale effects. Model reference diameters were 0.30, 0.61, and 1.07 meters (1.0, 2.0, and 3.5 ft) for the modified cross; and nominal diameters of 0.25 and 0.52 meter (0.83 and 1.7 ft) for the disk-gap-band; and 0.55 meter (1.8 ft) for the hemisflo. Reefing information is presented for the 0.61-meter-diameter cross and the 0.52-meter-diameter disk-gap-band. Results are presented in the form of the variation of steady-state average drag coefficient with Mach number. General stability characteristics of each parachute are discussed. Included are comments on canopy coning, spinning, and fluttering motions

Development of a real-time aeroperformance analysis technique for the X-29A advanced technology demonstrator

The X-29A advanced technology demonstrator has shown the practicality and advantages of the capability to compute and display, in real time, aeroperformance flight results. This capability includes the calculation of the in-flight measured drag polar, lift curve, and aircraft specific excess power. From these elements many other types of aeroperformance measurements can be computed and analyzed. The technique can be used to give an immediate postmaneuver assessment of data quality and maneuver technique, thus increasing the productivity of a flight program. A key element of this new method was the concurrent development of a real-time in-flight net thrust algorithm, based on the simplified gross thrust method. This net thrust algorithm allows for the direct calculation of total aircraft drag

Scaling the propulsive performance of heaving and pitching foils

Scaling laws for the propulsive performance of rigid foils undergoing oscillatory heaving and pitching motions are presented. Water tunnel experiments on a nominally two-dimensional flow validate the scaling laws, with the scaled data for thrust, power, and efficiency all showing excellent collapse. The analysis indicates that the behaviour of the foils depends on both Strouhal number and reduced frequency, but for motions where the viscous drag is small the thrust closely follows a linear dependence on reduced frequency. The scaling laws are also shown to be consistent with biological data on swimming aquatic animals.Comment: 11 page