Hepatitis C virus vaccine: Challenges and prospects

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. The hepatitis C virus (HCV) causes both acute and chronic infection and continues to be a global problem despite advances in antiviral therapeutics. Current treatments fail to prevent reinfection and remain expensive, limiting their use to developed countries, and the asymptomatic nature of acute infection can result in individuals not receiving treatment and unknowingly spreading HCV. A prophylactic vaccine is therefore needed to control this virus. Thirty years since the discovery of HCV, there have been major gains in understanding the molecular biology and elucidating the immunological mechanisms that underpin spontaneous viral clearance, aiding rational vaccine design. This review discusses the challenges facing HCV vaccine design and the most recent and promising candidates being investigated

Heavy to Light Meson Exclusive Semileptonic Decays in Effective Field Theory of Heavy Quark

We present a general study on exclusive semileptonic decays of heavy (B, D, B_s) to light (pi, rho, K, K^*) mesons in the framework of effective field theory of heavy quark. Transition matrix elements of these decays can be systematically characterized by a set of wave functions which are independent of the heavy quark mass except for the implicit scale dependence. Form factors for all these decays are calculated consistently within the effective theory framework using the light cone sum rule method at the leading order of 1/m_Q expansion. The branching ratios of these decays are evaluated, and the heavy and light flavor symmetry breaking effects are investigated. We also give comparison of our results and the predictions from other approaches, among which are the relations proposed recently in the framework of large energy effective theory.Comment: 18 pages, ReVtex, 5 figures, added references and comparison of results, and corrected signs in some formula

Structural, mineralogical, and biochemical diversity in the lower part of the pearl layer of cultivated seawater pearls from Polynesia

A series of Polynesian pearls has been investigated with particular attention to the structural and compositional patterns of the early developmental stages of the pearl layer. These initial steps in pearl formation bear witness of the metabolic changes that have occurred during the pearl-sac formation. The resulting structurally and biochemically complex structures have been investigated using a variety of techniques that provide us with information concerning both mineral phases and the organic components. Results are discussed with respect to our understanding of the biomineralization mechanisms, as well as for the grafting process

An examination of business occupier relocation decision making : distinguishing small and large firm behaviour

This paper explores how business occupiers decide whether and where to relocate. It captures the experience and behaviour of a range of sizes and types of business occupier and subjects their decision-making processes to detailed scrutiny. A linear three-stage decision model is used to sequence and structure interviews with individuals who have intimate involvement with the relocation of 28 firms and organizations in Tyne and Wear, in the north-east of England. The 'constant comparative' method is used to analyse the interview data, from which emerges 18 key concepts, comprising 51 characteristic components. Using an axial approach, these are organized into 10 cross-cutting themes that represent the main areas of consideration or influence on the thinking of the people involved in determining whether a firm or organization should relocate and, if so, where to. The resulting analysis finds that organizations adopt varying degrees of sophistication when making relocation decisions; small firms are more inclined to make decisions based on constrained information; larger organizations adopt a more complex approach. Regardless of firm size, key individuals exert considerable influence over the decision-making process and its outcome

Helical Nanofilaments and the High Chirality Limit of Smectics-A

Liquid crystalline systems exhibiting both macroscopic chirality and smectic order experience frustration resulting in mesophases possessing complex three-dimensional order. In the twist-grain-boundary phase, defect lattices mediate the propagation of twist throughout the system. We propose a new chiral smectic structure composed of a lattice of chiral bundles as a model of the helical nanofilament (B4) phase of bent core smectics.Comment: 4 pages, 3 figures, the full catastroph

Predictions on B→πlˉνlB \to \pi \bar{l} \nu_l, D→πlˉνlD \to \pi \bar{l} \nu_l and D→KlˉνlD\to K \bar{l} \nu_l from QCD Light-Cone Sum Rules

The $f^+$ form factors of the $B\to \pi$, $D\to \pi$ and $D\to K$ transitions are calculated from QCD light-cone sum rules (LCSR) and used to predict the widths and differential distributions of the exclusive semileptonic decays $B\to \pi \bar{l}\nu_l$, $D \to\pi \bar{l}\nu_l$ and $D \to K \bar{l}\nu_l$, where $l=e,\mu$. The current theoretical uncertainties are estimated. The LCSR results are found to agree with the results of lattice QCD calculations and with experimental data on exclusive semileptonic D decays. Comparison of the LCSR prediction on $B\to \pi \bar{l} \nu_l$ with the CLEO measurement yields a value of |V_{ub}| in agreement with other determinations.Comment: 24 pages, 12 figures, Latex, epsfig, some additional remarks on the two-pole parameterization, prediction on the $B\to K$ form factor added, version to appear in Phys. Rev.

Changing times in England: the influence on geography teachers’ professional practice

School geography in England has been characterised as a pendulum swinging between policies that emphasise curriculum and pedagogy alternately. In this paper, I illustrate the influence of these shifts on geography teacher's professional practice, by drawing on three “moments” from my experience as a student, teacher and teacher educator. Barnett's description of teacher professionalism as a continuous project of “being” illuminates how geography teachers can adapt to competing influences. It reflects teacher professionalism as an unfinished project, which is responsive, but not beholden, to shifting trends, and is informed by how teachers frame and enact policies. I argue that recognising these contextual factors is key to supporting geography teachers in “being” geography education professionals. As education becomes increasingly competitive on a global scale, individual governments are looking internationally for “solutions” to improve educational rankings. In this climate, the future of geography education will rest on how teachers react locally to international trends. Geography teacher educators can support this process by continuing to inform the field through meaningful geography education research, in particular in making the contextual factors of their research explicit. This can be supported through continued successful international collaboration in geography education research

Enhanced b→sgb\to sg Decay, Inclusive η′\eta^\prime Production, and the Gluon Anomaly

The experimental hint of large $B\to \eta^\prime + X_s$ is linked to the $b\to s$ penguins via the gluon anomaly. Using running $\alpha_s$ in the $\eta^\prime$-$g$-$g$ coupling, the standard $b\to sg^*$ penguin alone seems insufficient, calling for the need of dipole $b\to sg$ at 10% level from new physics, which could also resolve the ${\cal B}_{s.l.}$ and charm counting problems. The intereference of standard and new physics contributions may result in direct CP asymmetries at 10% level, which could be observed soon at B Factories.Comment: 12 pages, revtex, 3 figs. (version to appear in Phys. Rev. Lett.

The Digital Life of Walkable Streets

Walkability has many health, environmental, and economic benefits. That is why web and mobile services have been offering ways of computing walkability scores of individual street segments. Those scores are generally computed from survey data and manual counting (of even trees). However, that is costly, owing to the high time, effort, and financial costs. To partly automate the computation of those scores, we explore the possibility of using the social media data of Flickr and Foursquare to automatically identify safe and walkable streets. We find that unsafe streets tend to be photographed during the day, while walkable streets are tagged with walkability-related keywords. These results open up practical opportunities (for, e.g., room booking services, urban route recommenders, and real-estate sites) and have theoretical implications for researchers who might resort to the use social media data to tackle previously unanswered questions in the area of walkability.Comment: 10 pages, 7 figures, Proceedings of International World Wide Web Conference (WWW 2015