18,998 research outputs found
Using diffusion MRI to discriminate areas of cortical grey matter
Cortical area parcellation is a challenging problem that is often approached by combining structural imaging (e.g., quantitative T1, diffusion-based connectivity) with functional imaging (e.g., task activations, topological mapping, resting state correlations). Diffusion MRI (dMRI) has been widely adopted to analyse white matter microstructure, but scarcely used to distinguish grey matter regions because of the reduced anisotropy there. Nevertheless, differences in the texture of the cortical 'fabric' have long been mapped by histologists to distinguish cortical areas. Reliable area-specific contrast in the dMRI signal has previously been demonstrated in selected occipital and sensorimotor areas. We expand upon these findings by testing several diffusion-based feature sets in a series of classification tasks. Using Human Connectome Project (HCP) 3T datasets and a supervised learning approach, we demonstrate that diffusion MRI is sensitive to architectonic differences between a large number of different cortical areas defined in the HCP parcellation. By employing a surface-based cortical imaging pipeline, which defines diffusion features relative to local cortical surface orientation, we show that we can differentiate areas from their neighbours with higher accuracy than when using only fractional anisotropy or mean diffusivity. The results suggest that grey matter diffusion may provide a new, independent source of information for dividing up the cortex
Advent of 2D rhenium disulfide (ReS(2)): fundamentals to applications
Published online: 30 January 2017Rhenium disulfide (ReS2) is a two-dimensional (2D) group VII transition metal dichalcogenide (TMD). It is attributed with structural and vibrational anisotropy, layer-independent electrical and optical properties, and metal-free magnetism properties. These properties are unusual compared with more widely used group VI-TMDs, e.g., MoS2, MoSe2, WS2 and WSe2. Consequently, it has attracted significant interest in recent years and is now being used for a variety of applications including solid state electronics, catalysis, and, energy harvesting and energy storage. It is anticipated that ReS2 has the potential to be equally used in parallel with isotropic TMDs from group VI for all known applications and beyond. Therefore, a review on ReS2 is very timely. In this first review on ReS2, we critically analyze the available synthesis procedures and their pros/cons, atomic structure and lattice symmetry, crystal structure, and growth mechanisms with an insight into the orientation and architecture of domain and grain boundaries, decoupling of structural and vibrational properties, anisotropic electrical, optical, and magnetic properties impacted by crystal imperfections, doping and adatoms adsorptions, and contemporary applications in different areas.Mohammad Rahman, Kenneth Davey, and Shi-Zhang Qia
Modeling near-field radiative heat transfer from sharp objects using a general 3d numerical scattering technique
We examine the non-equilibrium radiative heat transfer between a plate and
finite cylinders and cones, making the first accurate theoretical predictions
for the total heat transfer and the spatial heat flux profile for
three-dimensional compact objects including corners or tips. We find
qualitatively different scaling laws for conical shapes at small separations,
and in contrast to a flat/slightly-curved object, a sharp cone exhibits a local
\emph{minimum} in the spatially resolved heat flux directly below the tip. The
method we develop, in which a scattering-theory formulation of thermal transfer
is combined with a boundary-element method for computing scattering matrices,
can be applied to three-dimensional objects of arbitrary shape.Comment: 5 pages, 4 figures. Corrected background information in the
introduction, results and discussion unchange
Combining HARDI datasets with more than one b-value improves diffusion MRI-based cortical parcellation
The role of the North Atlantic Oscillation in controlling U.K. butterfly population size and phenology
Copyright @ 2012 The Authors. This article can be accessed from the links below.This article has been made available through the Brunel Open Access Publishing Fund.1. The North Atlantic Oscillation (NAO) exerts considerable control on U.K. weather. This study investigates the impact of the NAO on butterfly abundance and phenology using 34 years of data from the U.K. Butterfly Monitoring Scheme (UKBMS). 2. The study uses a multi-species indicator to show that the NAO does not affect overall U.K. butterfly population size. However, the abundance of bivoltine butterfly species, which have longer flight seasons, were found to be more likely to respond positively to the NAO compared with univoltine species, which show little or a negative response. 3. A positive winter NAO index is associated with warmer weather and earlier flight dates for Anthocharis cardamines (Lepidoptera: Pieridae), Melanargia galathea (Lepidoptera: Nymphalidae), Aphantopus hyperantus (Lepidoptera: Nymphalidae), Pyronia tithonus (Lepidoptera: Nymphalidae), Lasiommata megera (Lepidoptera: Nymphalidae) and Polyommatus icarus (Lepidoptera: Lycaenidae). In bivoltine species, the NAO affects the phenology of the first generation, the timing of which indirectly controls the timing of the second generation. 4. The NAO influences the timing of U.K. butterfly flight seasons more strongly than it influences population size.This study was supported by a multi-agency consortium led by the U.K. Department for Environment, Food and Rural Affairs (Defra), including the Countryside Council for Wales, the Joint Nature Conservation Committee, the Forestry Commission, Natural England, the Natural Environment Research Council, the Northern Ireland Environment Agency and Scottish Natural Heritage. This article is made available through the Brunel Open Access Publishing Fund
Determination of the QCD color factor ratio CA/CF from the scale dependence of multiplicity in three jet events
I examine the determination of the QCD color factor ratio CA/CF from the
scale evolution of particle multiplicity in e+e- three jet events. I fit an
analytic expression for the multiplicity in three jet events to event samples
generated with QCD multihadronic event generators. I demonstrate that a one
parameter fit of CA/CF yields the expected result CA/CF=2.25 in the limit of
asymptotically large energies if energy conservation is included in the
calculation. In contrast, a two parameter fit of CA/CF and a constant offset to
the gluon jet multiplicity, proposed in a recent study, does not yield
CA/CF=2.25 in this limit. I apply the one parameter fit method to recently
published data of the DELPHI experiment at LEP and determine the effective
value of CA/CF from this technique, at the finite energy of the Z0 boson, to be
1.74+-0.03+-0.10, where the first uncertainty is statistical and the second is
systematic.Comment: 20 pages including 6 figures Version 2 corrects typographical error
in equation (2
The added value of a European Reference Network on rare and complex connective tissue and musculoskeletal diseases : insights after the first 5 years of the ERN ReCONNET
Funding Information: I. Bulina has received honoraria from Abbvie, Boehringer Ingelheim, Janssen and Pfizer. N. Costedoat-Chalumeau has received grants from UCB for a clinical research study. M. Matucci-Ce rinic has received grants from Janssen and MSD, and he is a member of speak ers bureau for Janssen, Sandoz, Bio gen, BI, Lilly and MSD. A. Meyer re ceived honoraria (<10,000 euros) from Lilly, LFB, Pfizer, Boehringer, Sanofi and research grants/support from CSL Behring, LFB, Sanofi, Fresenius Kabi and BMS. L. Mouthon received a grant from LFB. J.M. van Laar has received honoraria from Abbvie, Boehringer In-gelheim, Celltrion, Galapagos, Magenta, Roche, and grants from Astra Zeneca, Boehringer Ingelheim, Roche and Thermofischer. J.K. de Vries-Bouwstra received consulting fees from Abbvie, Janssen and Boehringer Ingelheim, and research grants from Roche, Galapagos and Janssen. The other authors have declared no competing interests. Publisher Copyright: © Copyright CliniCal and ExpErimEntal rhEumatology 2022.In order to address the main challenges related to the rare diseases (RDs) the European Commission launched the European Reference Networks (ERNs), virtual networks involving healthcare providers (HCPs) across Europe. The mission of the ERNs is to tackle low prevalence and RDs that require highly specialised treatment and a concentration of knowledge and resources. In fact, ERNs offer the potential to give patients and healthcare professionals across the EU access to the best expertise and timely exchange of lifesaving knowledge, trying to make the knowledge travelling more than patients. For this reason, ERNs were established as concrete European infrastructures, and this is particularly crucial in the framework of rare and complex diseases in which no country alone has the whole knowledge and capacity to treat all types of patients. It has been five years since their kick-off launch in Vilnius in 2017. The 24 ERNs have been intensively working on different transversal areas, including patient management, education, clinical practice guidelines, patients' care pathways and many other fundamental topics. The present work is therefore aimed not only at reporting a summary of the main activities and milestones reached so far, but also at celebrating the first 5 years of the ERN on Rare and Complex Connective Tissue and Musculo-skeletal Diseases (ReCONNET), in which the members of the network built together one of the 24 infrastructures that are hopefully going to change the scenario of rare diseases across the EU.publishersversionPeer reviewe
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2D Visualization of the Psoriasis Transcriptome Fails to Support the Existence of Dual-Secreting IL-17A/IL-22 Th17 T Cells.
The present paradigm of psoriasis pathogenesis revolves around the IL-23/IL-17A axis. Dual-secreting Th17 T cells presumably are the predominant sources of the psoriasis phenotype-driving cytokines, IL-17A and IL-22. We thus conducted a meta-analysis of independently acquired RNA-seq psoriasis datasets to explore the relationship between the expression of IL17A and IL22. This analysis failed to support the existence of dual secreting IL-17A/IL-22 Th17 cells as a major source of these cytokines. However, variable relationships amongst the expression of psoriasis susceptibility genes and of IL17A, IL22, and IL23A were identified. Additionally, to shed light on gene expression relationships in psoriasis, we applied a machine learning nonlinear dimensionality reduction strategy (t-SNE) to display the entire psoriasis transcriptome as a 2-dimensonal image. This analysis revealed a variety of gene clusters, relevant to psoriasis pathophysiology but failed to support a relationship between IL17A and IL22. These results support existing theories on alternative sources of IL-17A and IL-22 in psoriasis such as a Th22 cells and non-T cell populations
On the importance of nonlinear modeling in computer performance prediction
Computers are nonlinear dynamical systems that exhibit complex and sometimes
even chaotic behavior. The models used in the computer systems community,
however, are linear. This paper is an exploration of that disconnect: when
linear models are adequate for predicting computer performance and when they
are not. Specifically, we build linear and nonlinear models of the processor
load of an Intel i7-based computer as it executes a range of different
programs. We then use those models to predict the processor loads forward in
time and compare those forecasts to the true continuations of the time seriesComment: Appeared in "Proceedings of the 12th International Symposium on
Intelligent Data Analysis
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