Scatter plot of the individual values of percentage of correct sequences in the 2Hz condition.

<p>Data from the male and female subjects are pooled together; solid lines represent the mean predicted value while dashed lines represent the normal ranges.</p

Time-series of reported versus predicted all-age ILI morbidity (hold-out validation).

<p>Reported all-age ILI morbidity compared with hold-out predictions (from 42^nd week of 2014 to 8^th week of 2015) generated by the query-based model and exponential smoothing.</p

Time-series of reported versus predicted age-class-specific ILI morbidity (hold-out validation).

<p>Reported age-class-specific ILI morbidity compared with hold-out predictions (from 42^nd week of 2014 to 8^th week of 2015) generated by the age-class-specific query-based models and exponential smoothing.</p

Pearson’s correlation coefficient between ILI morbidity and query volume of selected entry terms.

<p>^a: Popular brand name of Paracetamol;</p><p>^b: Only monthly data were available</p><p>Pearson’s correlation coefficient between ILI morbidity and query volume of selected entry terms.</p

Finger motor performance measured by means of the GAS system.

<p>Finger motor performance measured by means of the GAS system.</p

Histograms of the observed and predicted distribution of CLs over 1 and 2 years.

<p>Histograms of the distribution of the number of cortical lesions counted over 1 and 2 years in the non-treated and in the 3 treated groups, and their probability distribution implied by the Poisson (blue lines), the zero-inflated Poisson (yellow lines), the Negative Binomial (red lines) and the zero-inflated Negative Binomial (green lines) models. The Akaike Information Criterion (AIC) is calculated on the whole group of patients adjusting for treatment arm. Lower values of the AIC indicate better fits.</p

Frequencies of new MRI CLs over 1 and 2 years observed and predicted under the Poisson, the NB, the ZIP and the ZINB models.

<p>Frequencies of new MRI CLs over 1 and 2 years observed and predicted under the Poisson, the NB, the ZIP and the ZINB models.</p

Relationship of finger motor performance parameters with age and gender.

<p>Relationship of finger motor performance parameters with age and gender.</p

Number of patients per arm for an active controlled trial with the number of new cortical lesions counted over 1 and 2 years.

<p>Number of patients per arm for an active controlled trial with the number of new cortical lesions counted over 1 and 2 years.</p

Mean, median, maximum and minimum values of breast density percentage evaluated on every MRI sequence with the semi-automated software.

<p>Results include both readings from both radiologists. IDEAL sequences (Iterative Decomposition of water and fat with Echo Asymmetry and Least squares estimation) are reported are WaterOnly and FatOnly. VIBRANT: Volume Imaging for Breast Assessment.</p