IL-7R^neg short-term effector _vs IL-7R^pos long-term memory T cells persistance at late time points after primary HCMV infection.

<p>Frequencies of IL-7R^pos T cells in <b>(A-B)</b> total memory and <b>(C-D)</b> HCMV-specific CD4⁺ or CD8⁺ T cells are reported. Data are from HCMV-seronegative subjects (“No infection”, n = 5, only for total memory), patients (both pregnant and non-pregnant) within 1 month (n = 25) or at 6–12 months (n = 18) after primary infection onset, and subjects with remote infection (n = 10). “HCMV-specific” indicates the sum of the single protein-specific T cells. Each symbol represents an individual and column upper limits indicate median values.</p

Frequencies of CD4⁺ and CD8⁺ T cells specific for HCMV proteins IE-1, pp65, gHgLpUL128L (pentamer) and gB in the naïve pool of HCMV-seronegative subjects and in the memory pool of subjects with primary or remote HCMV infection.

<p><b>A, B.</b> Frequencies of protein-specific <b>(A)</b> CD4⁺ and <b>(B)</b> CD8⁺ naïve T cells in 6 HCMV-seronegative subjects are reported. Each symbol represents an individual and horizontal black lines indicate median values. <b>C, D.</b> Frequencies of protein-specific <b>(C)</b> CD4⁺ and <b>(D)</b> CD8⁺ memory T cells in 6 patients with primary HCMV infection tested within one month and 6–12 months after infection onset. <b>E, F.</b> Frequencies of protein-specific <b>(E)</b> CD4⁺ and <b>(F)</b> CD8⁺ memory T cells in 7 subjects with remote HCMV infection are reported.</p

Characteristics of the 27 patients with primary HCMV infection.

<p>Characteristics of the 27 patients with primary HCMV infection.</p