94 research outputs found
Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease
Physics of Planet Trapping with Applications to HL Tau
We explore planet formation in the HL Tau disk and possible origins of the
prominent gaps and rings observed by ALMA. We investigate whether dust gaps are
caused by dynamically trapped planetary embryos at the ice lines of abundant
volatiles. The global properties of the HL Tau disk (total mass, size) at its
current age are used to constrain an evolving analytic disk model describing
its temperature and density profiles. By performing a detailed analysis of the
planet-disk interaction for a planet near the water ice line including a
rigorous treatment of the dust opacity, we confirm that water is sufficiently
abundant (1.5x10^-4 molecules per H) to trap planets at its ice line due to an
opacity transition. When the abundance of water is reduced by 50% planet
trapping disappears. We extend our analysis to other planet traps: the heat
transition, dead zone edge, and the CO_2 ice line and find similar trapping.
The formation of planets via planetesimal accretion is computed for dynamically
trapped embryos at the water ice line, dead zone, and heat transition. The end
products orbit in the inner disk (R < 3 AU), unresolved by ALMA, with masses
that range between sub-Earth to 5 Jupiter masses. While we find that the dust
gaps correspond well with the radial positions of the CO_2 , CH_4 , and CO ice
lines, the planetesimal accretion rates at these radii are too small to build
large embryos within 1 Myr.Comment: Accepted for publication in MNRA
Prescribing of psychotropic medications to the elderly population of a Canadian province: a retrospective study using administrative databases
Background. Psychotropic medications, in particular second-generation antipsychotics (SGAs) and benzodiazepines, have been associated with harm in elderly populations. Health agencies around the world have issued warnings about the risks of prescribing such medications to frail individuals affected by dementia and current guidelines recommend their use only in cases where the benefits clearly outweigh the risks. This study documents the use of psychotropic medications in the entire elderly population of a Canadian province in the context of current clinical guidelines for the treatment of behavioural disturbances. Methods. Prevalent and incident utilization of antipsychotics, benzodiazepines and related medications (zopiclone and zaleplon) were determined in the population of Manitobans over age 65 in the time period 1997/98 to 2008/09 fiscal years. Comparisons between patients living in the community and those living in personal care (nursing) homes (PCH) were conducted. Influence of sociodemographic characteristics on prescribing was assessed by generalized estimating equations. Non-optimal use was defined as the prescribing of high dose of antipsychotic medications and the use of combination therapy of a benzodiazepine (or zopiclone/zaleplon) with an antipsychotic. A decrease in intensity of use over time and lower proportions of patients treated with antipsychotics at high dose or in combination with benzodiazepines (or zopiclone/zaleplon) was considered a trend toward better prescribing. Multiple regression analysis determined predictors of non-optimal use in the elderly population. Results. A 20-fold greater prevalent utilization of SGAs was observed in PCH-dwelling elderly persons compared to those living in the community. In 2008/09, 27% of PCH-dwelling individuals received a prescription for an SGA. Patient characteristics, such as younger age, male gender, diagnoses of dementia (or use of an acetylcholinesterase inhibitor) or psychosis in the year prior the prescription, were predictors of non-optimal prescribing (e.g., high dose antipsychotics). During the period 2002/3 and 2007/8, amongst new users of SGAs, 10.2% received high doses. Those receiving high dose antipsychotics did not show high levels of polypharmacy. Conclusions. Despite encouraging trends, the use of psychotropic medications remains high in elderly individuals, especially in residents of nursing homes. Clinicians caring for such patients need to carefully assess risks and benefits
Formation of Planetary Populations II: Effects of Initial Disk Size & Radial Dust Drift
Recent ALMA observations indicate that while a range of disk sizes exist,
typical disk radii are small, and that radial dust drift affects the
distribution of solids in disks. Here we explore the consequences of these
features in planet population synthesis models. A key feature of our model is
planet traps - barriers to otherwise rapid type-I migration of forming planets
- for which we include the ice line, heat transition, and outer edge of the
dead zone. We find that the ice line plays a fundamental role in the formation
of warm Jupiters. In particular, the ratio of super Earths to warm Jupiters
formed at the ice line depend sensitively on the initial disk radius. Initial
gas disk radii of 50 AU results in the largest super Earth populations,
while both larger and smaller disk sizes result in the ice line producing more
gas giants near 1 AU. This transition between typical planet class formed at
the ice line at various disk radii confirms that planet formation is
fundamentally linked to disk properties (in this case, disk size), and is a
result that is only seen when dust evolution effects are included in our
models. Additionally, we find that including radial dust drift results in the
formation of more super Earths between 0.1 - 1 AU, having shorter orbital radii
than those produced in models where dust evolution effects are not included.Comment: 24 pages, 13 figures. Submitted to MNRAS; revised in response to
refere
Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites
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